Results 41 to 50 of about 3,256,020 (309)

Effectiveness of a Novel Low‐Density Lipoprotein Apheresis Device Rheocarna in Patients Undergoing Hemodialysis With Chronic Limb‐Threatening Ischemia: A Single‐Center Retrospective Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Chronic limb‐threatening ischemia (CLTI) is a severe form of lower‐extremity artery disease characterized by distal lesions and microcirculatory impairment, limiting revascularization efficacy. Rheocarna is a direct hemoperfusion low‐density lipoprotein (LDL) adsorption device with potential rheological and anti‐inflammatory ...
Kunihiro Ishioka, Takayasu Ohtake, Kei Ohmori, Chika Shibuya, Tomoki Tsukahara, Mizuki Yamano, Yasuhiro Mochida, Machiko Oka, Kyoko Maesato, Yusuke Tsukamoto, Hidekazu Moriya, Sumi Hidaka, Shuzo Kobayashi   +12 more
wiley   +1 more source

A novel pyrrolidine-chalcone derivative exhibits synergistic anti-cervical cancer activity by dual-targeting MDM2-p53 axis and ferroptosis pathway

Frontiers in Pharmacology
IntroductionCervical cancer remains a serious threat to women’s health, driving the need for effective and low-toxicity therapeutics. This study designed novel pyrrolidine-chalcone derivatives targeting the MDM2-p53 interaction.MethodsA series of ...
Hainimu Xiamuxi, XinYi Deng, Mourboul Ablise, Tong Yan, Madina Imam, Yu Wang, MingHui Zu, Wutiekuer Wumaier   +7 more
doaj   +1 more source

Ecological risk of microplastic toxicity to earthworms in soil: A bibliometric analysis

Frontiers in Environmental Science, 2023
Accumulation of microplastics (MPs) in soil is a serious environmental concern. Addition of exogenous MPs can alter structure and physicochemical properties of and material transport in soil.
Sen Guo, Sen Guo, Sen Guo, Qiong Wang, Qiong Wang, Zishuang Li, Yanhua Chen, Yanhua Chen, Hongjie Li, Jiajia Zhang, Jiajia Zhang, Xuexia Wang, Xuexia Wang, Jiawei Liu, Jiawei Liu, Jiawei Liu, Bing Cao, Bing Cao, Guoyuan Zou, Guoyuan Zou, Baogui Zhang, Meng Zhao, Meng Zhao   +22 more
doaj   +1 more source

Prognosis of Long‐Term Continuous Renal Replacement Therapy and the Impact of Combined Continuous Intravenous Sodium Infusion Therapy

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Patients requiring long‐term continuous renal replacement therapy (CRRT) generally have poor prognoses. This study evaluated whether adding continuous intravenous sodium infusion (cIVNa) is associated with improved hemodynamics and outcomes in patients undergoing long‐term CRRT for ≥ 7 days.
Akinori Yamaguchi, Atsuyoshi Mita, Kosuke Sonoda, Makoto Harada, Koji Hashimoto, Hiroshi Imamura, Yuji Kamijo   +6 more
wiley   +1 more source

A Prospective Survey on Safety of Sustained-Release Theophylline in Treatment of Asthma and COPD

Allergology International, 2006
Background: Theophylline is a useful drug for the treatment of asthma. The Asthma Prevention and Management Guidelines (JGL) recommend use of sustained-release theophylline products as controllers and of injectable aminophylline products as relievers ...
Sohei Makino, Mitsuru Adachi, Ken Ohta, Norio Kihara, Sigenori Nakajima, Sankei Nishima, Takeshi Fukuda, Terumasa Miyamoto   +7 more
doaj   +1 more source

Serum Myonectin Levels Are Positively Associated With Physical Function and Lower Frailty‐Related Limitation in Maintenance Hemodialysis Patients: A Cross‐Sectional Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Maintenance hemodialysis (MHD) patients frequently suffer from frailty, characterized by reduced physical function and poor prognosis. Myokines, such as myonectin, secreted by muscle, are emerging regulators of systemic health. This study investigated the relationship between serum myonectin, adipokines (adiponectin, omentin), and ...
Kenichi Kono, Yoshifumi Moriyama, Koji Ohashi, Naoya Otaka, Minako Tatsumi, Toyoaki Murohara, Noriyuki Ouchi, Satoru Oshima   +7 more
wiley   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Measuring and locating the changes in protein structure using MELO

Nature Communications
Understanding the impact that subtle variations (missense mutation, environmental change, ion chelation, ligand binding, etc.) have on protein structure helps to reveal their biological effects, but remain extremely challenging due to the difficulty in ...
Lingyan Zheng, Yang Liao, Yintao Zhang, Mingxuan Liu, Mingkun Lu, Tingting Fu, Shuiyang Shi, Xiuna Sun, Chengbin Gu, Huaicheng Sun, Minjie Mou, Haibin Dai, Feng Zhu   +12 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Dual-stiffness nanoparticles for compartment-specific drug delivery in stroke

Nature Communications
Ischemic stroke presents a dual therapeutic challenge, involving dynamic and compartmentalized pathology in both the peripheral immune system and the central nervous system.
Hui Liu, Juanjuan Zheng, Yaosheng Li, Rouxuan Wang, Zefeng Yang, Yunfei Dong, Yuankai Sun, Zhiwei Du, Liang Pei, Xiaoyu Qiu, Bo Zhao, Lu Li, Jiahe Wu, Xuejin Li, Xinchi Jiang, Chun-Xia Zhao, Jianqing Gao   +16 more
doaj   +1 more source