Results 51 to 60 of about 1,548,001 (241)
Zero-order drug release obtained with gradient matrix systems based on hydrophilic polymers
, 2011 The use of powder layering technology was explored to prepare hydrophilic matrix systems aimed at a zero-order release of drugs. Systems with 5 layers with decreasing drug concentration from the inner to the outer one were prepared by applying powders ...
A. Foppoli +5 more
core +1 more source
Interaction of Alkannin with CPEB4 Contributes to Its Antitumor Effects in Melanoma
BiomoleculesMelanoma is a highly aggressive malignancy characterized by strong invasive and metastatic potential. CPEB4 has been implicated in melanoma progression and may serve as a potential therapeutic target.
Parwen Parhat +5 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Measuring and locating the changes in protein structure using MELO
Nature CommunicationsUnderstanding the impact that subtle variations (missense mutation, environmental change, ion chelation, ligand binding, etc.) have on protein structure helps to reveal their biological effects, but remain extremely challenging due to the difficulty in ...
Lingyan Zheng +12 more
doaj +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Dual-stiffness nanoparticles for compartment-specific drug delivery in stroke
Nature CommunicationsIschemic stroke presents a dual therapeutic challenge, involving dynamic and compartmentalized pathology in both the peripheral immune system and the central nervous system.
Hui Liu +16 more
doaj +1 more source
PharmaceuticalsObjective: This article investigated the structural characteristics, powder properties, and performance variations of co-processed pregelatinized starch (PS) and microcrystalline cellulose (MCC) at varying ratios.
Yong Bi +4 more
doaj +1 more source
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
Survey of common factors to determine suitability for work release
, 1969 This archived document is maintained by the Oregon State Library as part of the Oregon Documents Depository Program. It is for informational purposes and may not be suitable for legal purposes.Title from PDF cover (viewed on June 20, 2016)."Work release
core
A Prospective Survey on Safety of Sustained-Release Theophylline in Treatment of Asthma and COPD
Allergology International, 2006 Background: Theophylline is a useful drug for the treatment of asthma. The Asthma Prevention and Management Guidelines (JGL) recommend use of sustained-release theophylline products as controllers and of injectable aminophylline products as relievers ...
Sohei Makino +7 more
doaj +1 more source