Results 71 to 80 of about 3,256,020 (309)
Advanced ScienceTumor immunotherapy has garnered significant attention, however, several notable challenges remain to be addressed, including: 1) enhancing active targeting, 2) effectively shielding immune checkpoints, and 3) inducing the transformation of “cold” tumor ...
Xuanxiang Zhai +6 more
doaj +1 more source
, 2004 Interpenetrating polymer network (IPN) hydrogels of chitosan with N-vinylpyrrolidinone (NVP) as well as its copolymer with 2 -hydroxyethyl met hacrylate (HEMA) were synthesised through the photoinitiator - free photopolymerisation technique.
Swami, Salesh N., Ng, Loo-Teck
core
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Regenerative TherapyMuse cell has become a promising source of cells for disease treatment due to its remarkable characteristics, including stress tolerance, low tumorigenicity, effective homing ability, and differentiation into histocompatibility cells after ...
Zhe Lu +5 more
doaj +1 more source
Prospective Survey on Safety Evaluation of Injectable Methylxanthines in Japan
Allergology International, 2006 Background: Injectable methylxanthines are useful drugs in the treatment of asthma. The Asthma Prevention and Management Guidelines (JGL) that are followed in Japan recommend the use of sustained-release theophylline to control the disease and use of ...
Ken Ohta +7 more
doaj +1 more source
Development of Injection-Molded Swellable/Erodible Capsules for Oral Pulsatile Release
, 2012 Swellable/erodible hydroxypropyl cellulose (HPC)-based capsular devices for pulsatile release were prepared by injection molding (IM) using a purposely-devised mold and a newly set up manufacturing process.
A. Foppoli +5 more
core
Controlled Drug Release from Nanoengineered Polysaccharides
, 2023 Polysaccharides are naturally occurring complex molecules with exceptional physicochemical properties and bioactivities. They originate from plant, animal, and microbial-based resources and processes and can be chemically modified.
Ilker S. Bayer
core +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Zero-order drug release obtained with gradient matrix systems based on hydrophilic polymers
, 2011 The use of powder layering technology was explored to prepare hydrophilic matrix systems aimed at a zero-order release of drugs. Systems with 5 layers with decreasing drug concentration from the inner to the outer one were prepared by applying powders ...
A. Foppoli +5 more
core