A new method for isolation and purification of fusion-competent inhibitory synaptic vesicles [PDF]
Current Research in PhysiologySynaptic vesicles specific to inhibitory GABA-releasing neurons are critical for regulating neuronal excitability. To study the specific molecular composition, architecture, and function of inhibitory synaptic vesicles, we have developed a new method to ...
Nisha Gopal +5 more
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Recently recycled synaptic vesicles use multi-cytoskeletal transport and differential presynaptic capture probability to establish a retrograde net flux during ISVE in central neurons [PDF]
Frontiers in Cell and Developmental Biology, 2023 Presynapses locally recycle synaptic vesicles to efficiently communicate information. During use and recycling, proteins on the surface of synaptic vesicles break down and become less efficient.
Mason Parkes +2 more
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Brain-derived synaptic vesicles have an intrinsic ability to sequester tubulin [PDF]
BMC BiologyBackground The presence and function of microtubules within the synaptic bouton has long been under investigation. In recent years, evidence has accumulated that connects the synaptic vesicle cluster to the local dynamics of microtubule ends. Nonetheless,
Tiago Mimoso +6 more
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Altered exocytosis of inhibitory synaptic vesicles at single presynaptic terminals of cultured striatal neurons in a knock-in mouse model of Huntington’s disease [PDF]
Frontiers in Molecular Neuroscience, 2023 Huntington’s disease (HD) is a progressive dominantly inherited neurodegenerative disease caused by the expansion of a cytosine-adenine-guanine (CAG) trinucleotide repeat in the huntingtin gene, which encodes the mutant huntingtin protein containing an ...
Chen Xu +10 more
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Tau forms synaptic nano-biomolecular condensates controlling the dynamic clustering of recycling synaptic vesicles [PDF]
Nature Communications, 2023 Neuronal communication relies on the release of neurotransmitters from various populations of synaptic vesicles. Despite displaying vastly different release probabilities and mobilities, the reserve and recycling pool of vesicles co-exist within a single
Shanley F. Longfield +10 more
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APP is cleaved by Bace1 in pre-synaptic vesicles and establishes a pre-synaptic interactome, via its intracellular domain, with molecular complexes that regulate pre-synaptic vesicles functions. [PDF]
PLoS ONE, 2014 Amyloid Precursor Protein (APP) is a type I membrane protein that undergoes extensive processing by secretases, including BACE1. Although mutations in APP and genes that regulate processing of APP, such as PSENs and BRI2/ITM2B, cause dementias, the ...
Dolores Del Prete +4 more
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Synaptic Vesicles Dynamics in Neocortical Epilepsy [PDF]
Frontiers in Cellular Neuroscience, 2020 Neuronal hyperexcitability often results from an unbalance between excitatory and inhibitory neurotransmission, but the synaptic alterations leading to enhanced seizure propensity are only partly understood.
Eleonora Vannini +8 more
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Mover is a homomeric phospho-protein present on synaptic vesicles. [PDF]
PLoS ONE, 2013 With remarkably few exceptions, the molecules mediating synaptic vesicle exocytosis at active zones are structurally and functionally conserved between vertebrates and invertebrates. Mover was found in a yeast-2-hybrid assay using the vertebrate-specific
Saheeb Ahmed +9 more
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The GTPase Rab26 links synaptic vesicles to the autophagy pathway [PDF]
eLife, 2015 Small GTPases of the Rab family not only regulate target recognition in membrane traffic but also control other cellular functions such as cytoskeletal transport and autophagy.
Beyenech Binotti +11 more
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Methods of measuring presynaptic function with fluorescence probes
Applied Microscopy, 2021 Synaptic vesicles, which are endogenous to neurotransmitters, are involved in exocytosis by active potentials and release neurotransmitters. Synaptic vesicles used in neurotransmitter release are reused via endocytosis to maintain a pool of synaptic ...
Yeseul Jang, Sung Rae Kim, Sung Hoon Lee
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