Results 21 to 30 of about 74,688 (303)

How do you recognize and reconstitute a synaptic vesicle after fusion? [version 1; referees: 3 approved]

F1000Research, 2017
Synaptic vesicle recycling is essential for sustained and reliable neurotransmission. A key component of synaptic vesicle recycling is the synaptic vesicle biogenesis process that is observed in synapses and that maintains the molecular identity of ...
Natali L. Chanaday, Ege T. Kavalali
doaj   +1 more source

The endosomal Q-SNARE, Syntaxin 7, defines a rapidly replenishing synaptic vesicle recycling pool in hippocampal neurons

Communications Biology, 2021
Yasunori Mori et al. find that a subset of neurotransmitter-bearing synaptic vesicles are marked for release by the endosomal Q-SNARE protein Stx7. They show that Stx7 function is necessary for the rapid replenishment of synaptic vesicles that is needed ...
Yasunori Mori, Koh-ichiro Takenaka, Yugo Fukazawa, Shigeo Takamori   +3 more
doaj   +1 more source

Amyloid-β acts as a regulator of neurotransmitter release disrupting the interaction between synaptophysin and VAMP2. [PDF]

, 2012
BACKGROUND: It is becoming increasingly evident that deficits in the cortex and hippocampus at early stages of dementia in Alzheimer's disease (AD) are associated with synaptic damage caused by oligomers of the toxic amyloid-β peptide (Aβ42).
Russell, CL, Claire L Russell, Beesley, PW, Sophia Semerdjieva, Ruth M Empson, Semerdjieva Sophia, Brian M Austen, Empson, RM, Austen Brian M., Empson Ruth M., Russell Claire L., Philip W Beesley, Alifragis Pavlos, Beesley Philip W., Semerdjieva, S, Alifragis, P, Pavlos Alifragis, Austen, BM   +17 more
core   +1 more source

Ontogeny of synaptophysin and synaptoporin in the central nervous system [PDF]

, 1993
The expression of the synaptic vesicle antigens synaptophysin (SY) and synaptoporin (SO) was studied in the rat striatum, which contains a nearly homogeneous population of GABAergic neurons. In situ hybridization revealed high levels of SY transcripts in
Marquéze-Pouey, B., Betz, H., Knaus, P., Grabs, D., Ovtscharoff, W., Bergmann, M., Gratzl, Manfred, Reisert, I.   +7 more
core   +1 more source

Rabconnectin-3α/DMXL2 Is Locally Enriched at the Synaptic Ribbon of Rod Photoreceptor Synapses

Cells, 2023
Ribbon synapses reliably transmit synaptic signals over a broad signalling range. Rod photoreceptor ribbon synapses are capable of transmitting signals generated by the absorption of single photons.
Alina Dittrich, Girish Ramesh, Martin Jung, Frank Schmitz   +3 more
doaj   +1 more source

Synaptophysin and synaptoporin expression in the developing rat olfactory system [PDF]

, 1993
The expressions of two closely related synaptic vesicle antigens synaptophysin and synaptoporin were examined in the olfactory system of the adult rat and during pre- and postnatal development.
Traurig, H., Marquéze-Pouey, B., Betz, H., Grabs, D., Bergmann, M., Gratzl, Manfred, Schuster, Th., Mayerhofer, Artur   +7 more
core   +1 more source

Morphologic and functional correlates of synaptic pathology in the cathepsin D knockout mouse model of congenital neuronal ceroid lipofuscinosis [PDF]

, 2011
Mutations in the cathepsin D (CTSD) gene cause an aggressive neurodegenerative disease (congenital neuronal ceroid lipofuscinosis) that leads to early death. Recent evidence suggests that presynaptic abnormalities play a major role in the pathogenesis of
Koch, Sabine, Cooper, Jonathan D, Svetlana M. Molchanova, Taira, Tomi, Tyynelä, Jaana, Jonathan D. Cooper, Ann K. Wright, Thomas H. Gillingwater, Sabine Koch, Andrew Edwards, Wright, Ann K, Gillingwater, Thomas H, Molchanova, Svetlana M, Jaana Tyynelä, Edwards, Andrew, Tomi Taira   +15 more
core   +1 more source

Structural Properties of Synaptic Transmission and Temporal Dynamics at Excitatory Layer 5B Synapses in the Adult Rat Somatosensory Cortex

Frontiers in Synaptic Neuroscience, 2018
Cortical computations rely on functionally diverse and highly dynamic synapses. How their structural composition affects synaptic transmission and plasticity and whether they support functional diversity remains rather unclear.
Astrid Rollenhagen, Ora Ohana, Kurt Sätzler, Claus C. Hilgetag, Dietmar Kuhl, Joachim H. R. Lübke, Joachim H. R. Lübke, Joachim H. R. Lübke   +7 more
doaj   +1 more source

Differential expression of synaptophysin and synaptoporin during pre- and postnatal development of the hippocampal network [PDF]

, 1994
The closely related synaptic vesicle membrane proteins synaptophysin and synaptoporin are abundant in the hippocampal formation of the adult rat. But the prenatal hippocampal formation contains only synaptophysin, which is first detected at embryonic day
M. Gratzl, Grabs, D., Fox, P. A., M. Brich, Brich, M., D. Grabs, M. Bergmann, Bergmann, M., Gratzl, Manfred, Schuster, Th., Th. Schuster, P. A. Fox   +11 more
core   +1 more source

Analysis of shape and spatial interaction of synaptic vesicles using data from focused ion beam scanning electron microscopy (FIB-SEM)

Frontiers in Neuroanatomy, 2015
The spatial interactions of synaptic vesicles in synapses were assessed after a detailed characterization of size, shape, and orientation of the synaptic vesicles.
Mahdieh eKhanmohammadi, Rasmus eWaagepetersen, Jon eSporring   +2 more
doaj   +1 more source