Results 1 to 10 of about 80,943 (163)
Synaptic vesicle endocytosis [PDF]
Current Opinion in Neurobiology, 1997 Exocytosis of synaptic vesicles is followed rapidly by reinternalization and recycling of their membranes. Recent studies have confirmed the key role of clathrin-mediated endocytosis in synaptic vesicle reformation and have identified new proteins that participate in this process.
Pietro De Camilli, Ottavio Cremona
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Synaptic vesicle-omics in mice captures signatures of aging and synucleinopathy [PDF]
Nature CommunicationsNeurotransmitter release occurs through exocytosis of synaptic vesicles. α-Synuclein’s function and dysfunction in Parkinson’s disease and other synucleinopathies is thought to be tightly linked to synaptic vesicle binding. Age is the biggest risk factor
Virginia Gao +15 more
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Endocytic protein AP180 assembly domain regulates synaptic vesicle size and release in Caenorhabditis elegans. [PDF]
PLoS BiologyNeuronal communication relies on neurotransmitter release from synaptic vesicles. The endocytic protein AP180 is critical for efficient vesicle recycling at presynaptic terminals, and its loss impairs neurotransmission, producing reduced release ...
Yu Wang +6 more
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Synaptic Vesicle Endocytosis in Different Model Systems
Frontiers in Cellular Neuroscience, 2018 Neurotransmission in complex animals depends on a choir of functionally distinct synapses releasing neurotransmitters in a highly coordinated manner. During synaptic signaling, vesicles fuse with the plasma membrane to release their contents. The rate of
Shigeki Watanabe, Quan Gan
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Synaptic Vesicle Glycoprotein 2C: a role in Parkinson’s disease [PDF]
Frontiers in Cellular NeuroscienceSynaptic Vesicle Glycoprotein 2C (SV2C), characterized by its selective expression in discrete brain regions such as the midbrain, has recently emerged as a promising player in Parkinson’s Disease (PD) – a debilitating neurodegenerative disorder ...
Chu Hua Chang +5 more
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Caveolin-1 deficiency impairs synaptic transmission in hippocampal neurons
Molecular Brain, 2021 In addition to providing structural support, caveolin-1 (Cav1), a component of lipid rafts, including caveolae, in the plasma membrane, is involved in various cellular mechanisms, including signal transduction. Although pre-synaptic membrane dynamics and
Soulmee Koh +3 more
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The synaptic vesicle proteome [PDF]
Journal of Neurochemistry, 2007 AbstractSynaptic vesicles are key organelles in neurotransmission. Vesicle integral or membrane‐associated proteins mediate the various functions the organelle fulfills during its life cycle. These include organelle transport, interaction with the nerve terminal cytoskeleton, uptake and storage of low molecular weight constituents, and the regulated ...
Jacqueline, Burré, Walter, Volknandt
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TRPM7 is critical for short-term synaptic depression by regulating synaptic vesicle endocytosis
eLife, 2021 Transient receptor potential melastatin 7 (TRPM7) contributes to a variety of physiological and pathological processes in many tissues and cells. With a widespread distribution in the nervous system, TRPM7 is involved in animal behaviors and neuronal ...
Zhong-Jiao Jiang +10 more
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Synaptic Vesicle Endocytosis [PDF]
Cold Spring Harbor Perspectives in Biology, 2012 Neurons can sustain high rates of synaptic transmission without exhausting their supply of synaptic vesicles. This property relies on a highly efficient local endocytic recycling of synaptic vesicle membranes, which can be reused for hundreds, possibly thousands, of exo-endocytic cycles. Morphological, physiological, molecular, and genetic studies over
Yasunori, Saheki, Pietro, De Camilli
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A delay in vesicle endocytosis by a C-terminal fragment of N-cadherin enhances Aβ synaptotoxicity
Cell Death Discovery, 2023 Synaptotoxic Aβ oligomers are thought to play a major role in the early pathology of Alzheimer´s disease (AD). However, the molecular mechanisms involved in Aβ-induced synaptic dysfunction and synapse damage remain largely unclear.
Zenghui Teng +5 more
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