Results 31 to 40 of about 80,943 (163)

Concurrent imaging of synaptic vesicle recycling and calcium dynamics.

Frontiers in Molecular Neuroscience, 2011
Synaptic transmission involves the calcium-dependent release of neurotransmitter from synaptic vesicles. Genetically encoded optical probes emitting different wavelengths of fluorescent light in response to neuronal activity offer a powerful approach to
Haiyan eLi, Sarah M. Foss, Sarah M. Foss, Yuriy eDobryy, Yuriy eDobryy, C. Kevin ePark, Samuel Andrew Hires, Samuel Andrew Hires, Nathan C. Shaner, Nathan C. Shaner, Roger Y. Tsien, Leslie C. Osborne, Susan M. Voglmaier   +12 more
doaj   +1 more source

Computational modeling of trans-synaptic nanocolumns, a modulator of synaptic transmission

Frontiers in Computational Neuroscience, 2022
Understanding synaptic transmission is of crucial importance in neuroscience. The spatial organization of receptors, vesicle release properties and neurotransmitter molecule diffusion can strongly influence features of synaptic currents. Newly discovered
Xiaoting Li, Xiaoting Li, Xiaoting Li, Gabriel Hémond, Antoine G. Godin, Antoine G. Godin, Nicolas Doyon, Nicolas Doyon   +7 more
doaj   +1 more source

Synaptic vesicle release regulates pre-myelinating oligodendrocyte-axon interactions in a neuron subtype-specific manner

Frontiers in Cellular Neuroscience
Oligodendrocyte-lineage cells are central nervous system (CNS) glia that perform multiple functions including the selective myelination of some but not all axons.
James R. Gronseth, Heather N. Nelson, Taylor L. Johnson, Taryn A. Mallon, Madeline R. Martell, Katrina A. Pfaffenbach, Bailey B. Duxbury, John T. Henke, Anthony J. Treichel, Jacob H. Hines   +9 more
doaj   +1 more source

Inositol Pyrophosphate Metabolism Regulates Presynaptic Vesicle Cycling at Central Synapses

iScience, 2020
Summary: The coordination of synaptic vesicle exocytosis and endocytosis supports neurotransmitter release from presynaptic terminals. Although inositol pyrophosphates, such as 5-diphosphoinositol pentakisphosphate (5-IP7), are versatile signaling ...
Seung Ju Park, Hoyong Park, Min-Gyu Kim, Seungjae Zhang, Seung Eun Park, Seyun Kim, ChiHye Chung   +6 more
doaj   +1 more source

Nonmuscle Myosin II helps regulate synaptic vesicle mobility at the Drosophila neuromuscular junction

BMC Neuroscience, 2010
Background Although the mechanistic details of the vesicle transport process from the cell body to the nerve terminal are well described, the mechanisms underlying vesicle traffic within nerve terminal boutons is relatively unknown.
Qiu Xinping, Seabrooke Sara, Stewart Bryan A   +2 more
doaj   +1 more source

Recycling of Synaptic Vesicles

, 1997
Publisher Summary A widely accepted model describes the synaptic vesicle cycle as a modification of the receptor-mediated recycling pathway present in all cells. This pathway, by which cell surface receptors, like transferrin or low-density lipoprotein receptors, are internalized and recycled back to the surface, involves two distinct vesicular ...
R, Bauerfeind, C, David, D, Grabs, P S, McPherson, Y, Nemoto, V I, Slepnev, K, Takei, P, De Camilli   +7 more
openaire   +2 more sources

Synaptic Transmission: Kinetics of synaptic-vesicle recycling [PDF]

Current Biology, 1995
The kinetics of different steps in synaptic-vesicle recycling, including exocytosis, internalization and repriming, have recently been estimated in various types of living cell.
Betz, William J., Wu, Ling-Gang
openaire   +2 more sources

Brain-derived synaptic vesicles have an intrinsic ability to sequester tubulin

BMC Biology
Background The presence and function of microtubules within the synaptic bouton has long been under investigation. In recent years, evidence has accumulated that connects the synaptic vesicle cluster to the local dynamics of microtubule ends. Nonetheless,
Tiago Mimoso, Aleksandr Korobeinikov, Alexander Stein, Dragomir Milovanovic, Silvio O. Rizzoli, Sarah Köster, Sofiia Reshetniak   +6 more
doaj   +1 more source

Short term synaptic depression imposes a frequency dependent filter on synaptic information transfer. [PDF]

PLoS Computational Biology, 2012
Depletion of synaptic neurotransmitter vesicles induces a form of short term depression in synapses throughout the nervous system. This plasticity affects how synapses filter presynaptic spike trains. The filtering properties of short term depression are
Robert Rosenbaum, Jonathan Rubin, Brent Doiron   +2 more
doaj   +1 more source

Synaptotagmin 7 is targeted to the axonal plasma membrane through γ-secretase processing to promote synaptic vesicle docking in mouse hippocampal neurons

eLife, 2021
Synaptotagmin 7 (SYT7) has emerged as a key regulator of presynaptic function, but its localization and precise role in the synaptic vesicle cycle remain the subject of debate.
Jason D Vevea, Grant F Kusick, Kevin C Courtney, Erin Chen, Shigeki Watanabe, Edwin R Chapman   +5 more
doaj   +1 more source