Results 51 to 60 of about 80,943 (163)

Synaptic vesicles [PDF]

Current Biology, 2004
Tyler, William J, Murthy, Venkatesh N
openaire   +2 more sources

Sleep deprivation increases levels of the synaptic density marker SV2A in the human brain.

PLoS Biology
Sleep is essential for synaptic homeostasis, a proposed mechanism whereby wakefulness leads to synaptic potentiation and sleep facilitates synaptic down-selection.
David Elmenhorst, Anna L Foerges, Ali Gordji-Nejad, Eva-Maria Elmenhorst, Tina Kroll, Andreas Matusch, Simone Beer, Bernd Neumaier, Philipp Krapf, Christoph Lerche, Alexander Drzezga, Andreas Bauer   +11 more
doaj   +1 more source

Acute Complexin Knockout Abates Spontaneous and Evoked Transmitter Release

Cell Reports, 2019
Summary: SNARE-mediated synaptic vesicle (SV) fusion is controlled by multiple regulatory proteins that determine neurotransmitter release efficiency.
Francisco José López-Murcia, Kerstin Reim, Olaf Jahn, Holger Taschenberger, Nils Brose   +4 more
doaj   +1 more source

Beyond the MUN domain, Munc13 controls priming and depriming of synaptic vesicles

Cell Reports
Summary: Synaptic vesicle docking and priming are dynamic processes. At the molecular level, SNAREs (soluble NSF attachment protein receptors), synaptotagmins, and other factors are critical for Ca2+-triggered vesicle exocytosis, while disassembly ...
Jeremy Leitz, Chuchu Wang, Luis Esquivies, Richard A. Pfuetzner, John Jacob Peters, Sergio Couoh-Cardel, Austin L. Wang, Axel T. Brunger   +7 more
doaj   +1 more source

Impaired docking and recycling of synaptic vesicles in inherited lysosomal sphingolipidoses

Cell Communication and Signaling
Cognitive, memory, and learning impairments are common features of many lysosomal sphingolipidoses, yet the underlying synaptic mechanisms remain poorly defined. Here, we examined the impact of galactosylceramidase (GALC) deficiency on synaptic structure
Diego Zelada, Natalia Saldivia, Ashna Konjeti, Shayla Samano, Michael S. Marshall, Rima Rebiai, Pearl Sutter, Zack Zurawski, Daniel Simchuk, Ruth Muchiri, Richard van Breemen, Daesung Shin, Maria I. Givogri, Stephen J. Crocker, Simon Alford, Ernesto R. Bongarzone   +15 more
doaj   +1 more source

Otoferlin acts as a Ca2+ sensor for vesicle fusion and vesicle pool replenishment at auditory hair cell ribbon synapses

eLife, 2017
Hearing relies on rapid, temporally precise, and sustained neurotransmitter release at the ribbon synapses of sensory cells, the inner hair cells (IHCs).
Nicolas Michalski, Juan D Goutman, Sarah Marie Auclair, Jacques Boutet de Monvel, Margot Tertrais, Alice Emptoz, Alexandre Parrin, Sylvie Nouaille, Marc Guillon, Martin Sachse, Danica Ciric, Amel Bahloul, Jean-Pierre Hardelin, Roger Bryan Sutton, Paul Avan, Shyam S Krishnakumar, James E Rothman, Didier Dulon, Saaid Safieddine, Christine Petit   +19 more
doaj   +1 more source

Synaptic vesicle proteins and active zone plasticity

Frontiers in Synaptic Neuroscience, 2016
Neurotransmitter is released from synaptic vesicles at the highly specialized presynaptic active zone. The complex molecular architecture of active zones mediates the speed, precision and plasticity of synaptic transmission.
Robert J Kittel, Manfred eHeckmann
doaj   +1 more source

A stem cell-based assay platform demonstrates alpha-synuclein dependent synaptic dysfunction in patient-derived cortical neurons

npj Parkinson's Disease
Alpha-synuclein (αS)-rich Lewy bodies and neurites in the cerebral cortex correlate with the presence of dementia in Parkinson disease (PD) and Dementia with Lewy bodies (DLB), but whether αS influences synaptic vesicle dynamics in human cortical neurons
Andrew J. White, Karis A. Clark, Kellianne D. Alexander, Nagendran Ramalingam, Tracy L. Young-Pearse, Ulf Dettmer, Dennis J. Selkoe, Gary P. H. Ho   +7 more
doaj   +1 more source

The synaptic vesicle and the cytoskeleton [PDF]

Biochemical Journal, 1987
Walker, J., Agoston, D.
openaire   +3 more sources

Deletion of VPS50 protein in mouse brain impairs synaptic function and behavior

BMC Biology
Background The VPS50 protein functions in synaptic and dense core vesicle acidification, and perturbations of VPS50 function produce behavioral changes in Caenorhabditis elegans.
Constanza Ahumada-Marchant, Carlos Ancatén-Gonzalez, Henny Haensgen, Bastian Brauer, Nicolas Merino-Veliz, Rita Droste, Felipe Arancibia, H. Robert Horvitz, Martha Constantine-Paton, Gloria Arriagada, Andrés E. Chávez, Fernando J. Bustos   +11 more
doaj   +1 more source