Results 41 to 50 of about 80,943 (163)
A novel synaptic vesicle fusion path in the rat cerebral cortex: the "saddle" point hypothesis. [PDF]
PLoS ONE, 2014 We improved freeze-fracture electron microscopy to study synapses in the neuropil of the rat cerebral cortex at ∼2 nm resolution and in three-dimensions.
Guido A Zampighi +2 more
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Cholesterol and synaptic vesicle exocytosis [PDF]
Communicative & Integrative Biology, 2010 LIPIDS MAY AFFECT SYNAPTIC FUNCTION IN AT LEAST TWO WAYS: by acting as ligands for effector proteins [e.g., phosphatidylinositol (4,5) bisphosphate, diacylglycerol-mediated signaling] or by modifying the physicochemical properties and molecular organization of synaptic membranes.
Rosa P, Fratangeli A
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Metabolic regulation of single synaptic vesicle exo- and endocytosis in hippocampal synapses
Cell ReportsSummary: Glucose has long been considered a primary energy source for synaptic function. However, it remains unclear to what extent alternative fuels, such as lactate/pyruvate, contribute to powering synaptic transmission. By detecting individual release
Jongyun Myeong +3 more
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Current Biology, 1999 Thomas Sudhof, Pietro De Camilli, Reinhard Jahn and Richard Scheller, to name but a few. Although the competitive, fast-paced nature of the field means you're unlikely to find them all in the same room at the same time.
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Synaptic Vesicle Pools and Dynamics [PDF]
Cold Spring Harbor Perspectives in Biology, 2012 Synaptic vesicles release neurotransmitter at chemical synapses, thus initiating the flow of information in neural networks. To achieve this, vesicles undergo a dynamic cycle of fusion and retrieval to maintain the structural and functional integrity of the presynaptic terminals in which they reside.
AbdulRasheed A, Alabi, Richard W, Tsien
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Actin cage for the synaptic vesicle liquid phase
Cell ReportsSummary: Synaptic vesicles in nerve terminals are organized into a cluster at the active zone, where they fuse with the presynaptic membrane during synaptic activity. This cluster is proposed to be organized as a liquid phase dependent on synapsin. Using
Lennart Brodin, Oleg Shupliakov
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Molecular Brain, 2018 Growing evidence has indicated that prefibrillar form of soluble amyloid beta (sAβ1–42) is the major causative factor in the synaptic dysfunction associated with AD.
Daehun Park, Sunghoe Chang
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Sharing vesicles between central presynaptic terminals: implications for synaptic function
Frontiers in Synaptic Neuroscience, 2010 Presynaptic terminals in hippocampal neurons house functionally distinct vesicle pools, the size, structure and biochemical features of which are major determinants of presynaptic strength and performance.
Kevin Staras, Tiago Branco, Tiago Branco
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Structural basis of synaptic vesicle assembly promoted by α-synuclein
Nature Communications, 2016 α-synuclein, a protein associated to Parkinson's disease, is involved in synaptic vesicle interaction and assembly. Here, the authors use NMR spectroscopy and super-resolution microscopy to unveil the nature and molecular mechanism of α-synuclein ...
Giuliana Fusco +10 more
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Spontaneous Vesicle Recycling in the Synaptic Bouton
Frontiers in Cellular Neuroscience, 2014 The trigger for synaptic vesicle exocytosis is Ca2+, which enters the synaptic bouton following action potential stimulation. However, spontaneous release of neurotransmitter also occurs in the absence of stimulation in virtually all synaptic boutons. It
Sven eTruckenbrodt +4 more
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