Results 21 to 30 of about 80,943 (163)
Effects of Excess Brain-Derived Human α-Synuclein on Synaptic Vesicle Trafficking
Frontiers in Neuroscience, 2021 α-Synuclein is a presynaptic protein that regulates synaptic vesicle trafficking under physiological conditions. However, in several neurodegenerative diseases, including Parkinson’s disease, dementia with Lewy bodies, and multiple system atrophy, α ...
Cristina Román-Vendrell +5 more
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F1000Research, 2017 Synaptic vesicle recycling is essential for sustained and reliable neurotransmission. A key component of synaptic vesicle recycling is the synaptic vesicle biogenesis process that is observed in synapses and that maintains the molecular identity of ...
Natali L. Chanaday, Ege T. Kavalali
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Research progress on vesicle cycle and neurological disorders
Journal of Pharmacy & Pharmaceutical Sciences, 2021 Neurons are special polarized cells whose synaptic vesicles release neurotransmitters into the synaptic cleft, acting on postsynaptic receptors and thus transmitting information from presynaptic to postsynaptic states.
Chengcheng Zhang, Li-Juan Zhu, Ce Chen
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Nature Structural & Molecular Biology, 2008 The core of the neurotransmitter release machinery is formed by SNARE complexes, which bring the vesicle and plasma membranes together and are key for fusion, and by Munc18-1, which controls SNARE-complex formation and may also have a direct role in fusion.
Josep, Rizo, Christian, Rosenmund
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Bio-Protocol, 2018 Release and recycling of synaptic vesicles are essential for neurotransmission and synaptic plasticity. To gain mechanistic understanding of these processes, direct measurements of vesicle release and retrieval is indispensable.
Roman Lazarenko +2 more
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Synaptic vesicle pools: an update [PDF]
Frontiers in Synaptic Neuroscience, 2010 During the last few decades synaptic vesicles have been assigned to a variety of functional and morphological classes or "pools". We have argued in the past (Rizzoli and Betz, 2005) that synaptic activity in several preparations is accounted for by the function of three vesicle pools: the readily releasable pool (docked at active zones and ready to go ...
Denker, Annette, Rizzoli, Silvio O.
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Binding of Rab3A to Synaptic Vesicles [PDF]
Journal of Biological Chemistry, 2000 Prenylated Rab GTPases cycle between membrane-bound and soluble forms. Membrane-bound GDP-Rabs interact with GDP dissociation inhibitor (GDI), resulting in the dissociation of a Rab.GDI complex, which in turn serves as a precursor for the membrane re-association of Rabs. We have now characterized the binding of Rab3A to synaptic vesicles in vitro using
Chou, J., Jahn, R.
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Loss of the Synaptic Vesicle Protein SV2B results in reduced neurotransmission and altered synaptic vesicle protein expression in the retina. [PDF]
PLoS ONE, 2009 The Synaptic Vesicle Protein 2 (SV2) family of transporter-like proteins is expressed exclusively in vesicles that undergo calcium-regulated exocytosis. Of the three isoforms expressed in mammals, SV2B is the most divergent.
Catherine W Morgans +6 more
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Protocol for Quantitative Analysis of Synaptic Vesicle Clustering in Axons of Cultured Neurons
STAR Protocols, 2020 Summary: Clustering of synaptic vesicles along the neuronal axons is a critical mechanism underpinning proper synaptic transmission. Here, we provide a detailed protocol for analyzing the distribution of synaptic vesicles in presynaptic boutons of ...
Ji Won Um +3 more
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Clarinet (CLA-1), a novel active zone protein required for synaptic vesicle clustering and release
eLife, 2017 Active zone proteins cluster synaptic vesicles at presynaptic terminals and coordinate their release. In forward genetic screens, we isolated a novel Caenorhabditis elegans active zone gene, clarinet (cla-1).
Zhao Xuan +6 more
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