Results 11 to 20 of about 80,943 (163)
Astroglial Connexin 43 Regulates Synaptic Vesicle Release at Hippocampal Synapses
Cells, 2023 Connexin 43, an astroglial gap junction protein, is enriched in perisynaptic astroglial processes and plays major roles in synaptic transmission. We have previously found that astroglial Cx43 controls synaptic glutamate levels and allows for activity ...
Giselle Cheung +6 more
doaj +1 more source
Incomplete vesicular docking limits synaptic strength under high release probability conditions
eLife, 2020 Central mammalian synapses release synaptic vesicles in dedicated structures called docking/release sites. It has been assumed that when voltage-dependent calcium entry is sufficiently large, synaptic output attains a maximum value of one synaptic ...
Gerardo Malagon +4 more
doaj +1 more source
Localization and mobility of synaptic vesicles in Myosin VI mutants of Drosophila. [PDF]
PLoS ONE, 2014 BACKGROUND: At the Drosophila neuromuscular junction (NMJ), synaptic vesicles are mobile; however, the mechanisms that regulate vesicle traffic at the nerve terminal are not fully understood.
Marta Kisiel +2 more
doaj +1 more source
Nature Communications, 2021 Synaptic vesicles store neurotransmitters and fuse with the pre-synaptic membrane when an action potential arrives at the nerve terminal. Here authors apply cross-linking mass spectrometry to study interactions of synaptic vesicle proteins and describe a
Sabine Wittig +7 more
doaj +1 more source
Frontiers in Cellular Neuroscience, 2022 The Tetraspanin (Tsp), CD63, is a transmembrane component of late endosomes and facilitates vesicular trafficking through endosomal pathways. Despite being widely expressed in the human brain and localized to late endosomes, CD63's role in regulating ...
Emily L. Hendricks +4 more
doaj +1 more source
Synaptic Vesicle Exocytosis [PDF]
Cold Spring Harbor Perspectives in Biology, 2011 Presynaptic nerve terminals release neurotransmitters by synaptic vesicle exocytosis. Membrane fusion mediating synaptic exocytosis and other intracellular membrane traffic is affected by a universal machinery that includes SNARE (for "soluble NSF-attachment protein receptor") and SM (for "Sec1/Munc18-like") proteins.
Thomas C, Südhof, Josep, Rizo
openaire +2 more sources
Clathrin coat controls synaptic vesicle acidification by blocking vacuolar ATPase activity
eLife, 2018 Newly-formed synaptic vesicles (SVs) are rapidly acidified by vacuolar adenosine triphosphatases (vATPases), generating a proton electrochemical gradient that drives neurotransmitter loading.
Zohreh Farsi +8 more
doaj +1 more source
Vesicle Clustering in a Living Synapse Depends on a Synapsin Region that Mediates Phase Separation
Cell Reports, 2020 Summary: Liquid-liquid phase separation is an increasingly recognized mechanism for compartmentalization in cells. Recent in vitro studies suggest that this organizational principle may apply to synaptic vesicle clusters. Here we test this possibility by
Arndt Pechstein +8 more
doaj +1 more source
Calcium dependence of neurotransmitter release at a high fidelity synapse
eLife, 2021 The Ca2+-dependence of the priming, fusion, and replenishment of synaptic vesicles are fundamental parameters controlling neurotransmitter release and synaptic plasticity.
Abdelmoneim Eshra +3 more
doaj +1 more source
Actin/Myosin-V- and Activity-Dependent Inter-synaptic Vesicle Exchange in Central Neurons
Cell Reports, 2017 Summary: Vesicle sharing between synaptic boutons is an important component of the recycling process that synapses employ to maintain vesicle pools. However, the mechanisms supporting and regulating vesicle transport during the inter-synaptic exchange ...
Michael W. Gramlich, Vitaly A. Klyachko
doaj +1 more source