Results 61 to 70 of about 80,943 (163)

Unveiling mitochondria as central components driving cognitive decline in alzheimer's disease through cross-transcriptomic analysis of hippocampus and entorhinal cortex microarray datasets

Heliyon
Alzheimer's disease (AD) is a prevalent neurodegenerative disorder characterized by symptoms such as memory loss and impaired learning. This study conducted a cross-transcriptomic analysis of AD using existing microarray datasets from the hippocampus (HC)
Pajaree Sonsungsan, Supatha Aimauthon, Nattawet Sriwichai, Poommaree Namchaiw   +3 more
doaj   +1 more source

A new method for isolation and purification of fusion-competent inhibitory synaptic vesicles

Current Research in Physiology
Synaptic vesicles specific to inhibitory GABA-releasing neurons are critical for regulating neuronal excitability. To study the specific molecular composition, architecture, and function of inhibitory synaptic vesicles, we have developed a new method to ...
Nisha Gopal, Jeremy Leitz, Chuchu Wang, Luis Esquivies, Richard A. Pfuetzner, Axel T. Brunger   +5 more
doaj   +1 more source

Dopamine neuron specific RNA-sequencing reveals Neprilysin 1 acts downstream of the cohesin complex to suppress learning

Communications Biology
We previously identified Stromalin, a cohesin complex subunit, as a learning suppressor in Drosophila melanogaster that acts by limiting synaptic vesicle numbers in dopamine neurons.
Illia Pimenov, Courtney M. MacMullen, Chisom Ezeh, Amoolya Sai Dwijesha, Justine David, Akhila Eswaran, Ronald L. Davis, Anna Phan   +7 more
doaj   +1 more source

Actomyosin-mediated inhibition of synaptic vesicle release under CB1R activation

Translational Psychiatry
Long-term synaptic plasticity is critical for adaptive function of the brain, but presynaptic mechanisms of functional plasticity remain poorly understood.
Maureen H. McFadden, Michel-Boris Emeritt, Hao Xu, Yihui Cui, Christophe Leterrier, Diana Zala, Laurent Venance, Zsolt Lenkei   +7 more
doaj   +1 more source

Synaptic vesicle architecture modulates α-synuclein conformation and pathogenic transitions in Parkinson's disease. [PDF]

Biosci Rep
Ranjan P.
europepmc   +1 more source

tDCS improves early Alzheimer's disease by synaptic vesicle fusion and release. [PDF]

Mil Med Res
Zhuang YY, Yan JM, Wu TC, Xu WS, Wu B, Xie X, Wang WJ, Lin HW, Jian JW, Wang JZ, Jiang T, Chen LM, Qiu YX, Hu ZY, Zhou YH, Yang T, Yang MG, Zhu JF, Tao J, Chen LD, Li WG, Yan K, Liu WL.   +22 more
europepmc   +1 more source

Selective, genetically induced increase in synaptic vesicle priming. [PDF]

Sci Adv
Aldahabi M, Balint F, Lorincz A, Lipstein N, Brose N, Nusser Z.   +5 more
europepmc   +1 more source

Disruption of Synaptic Vesicle Trafficking in Alzheimer's and Parkinson's Disease: Mechanisms and Therapeutic Implication. [PDF]

Int J Mol Sci
Zhu Y, Zhao L, Li Y, Tian M, Liao Y, Huang J, Guo P, Xie Y.   +7 more
europepmc   +1 more source

FCHO1 fine-tunes synaptic vesicle endocytosis in an activity-dependent manner. [PDF]

Mol Brain
Lee HJ, Lee W, Kim SH.
europepmc   +1 more source

Ketogenic diet dampens excitatory neurotransmission by shrinking synaptic vesicle pools. [PDF]

Cell Rep
Stunault MI, Deng PY, Yadav A, Periandri EM, de Luna Vitorino FN, Thomsen MB, Sponagel J, Barfield AJ, Ponce RJ, Foroughi L, Garcia BA, Egervari G, Klyachko VA, Ashrafi G.   +13 more
europepmc   +1 more source