Results 61 to 70 of about 634,741 (343)

The presynaptic ribbon maintains vesicle populations at the hair cell afferent fiber synapse [PDF]

, 2018
The ribbon is the structural hallmark of cochlear inner hair cell (IHC) afferent synapses, yet its role in information transfer to spiral ganglion neurons (SGNs) remains unclear.
Becker, Lars, Kachar, Bechara, Maxeiner, Stephan, Niwa, Mamiko, Ricci, Anthony J, Rutherford, Mark A, Schnee, Michael E, Sun, Willy, Talaei, Sara   +8 more
core   +2 more sources

EVIDENCE FOR RECYCLING OF SYNAPTIC VESICLE MEMBRANE DURING TRANSMITTER RELEASE AT THE FROG NEUROMUSCULAR JUNCTION

Journal of Cell Biology, 1973
When the nerves of isolated frog sartorius muscles were stimulated at 10 Hz, synaptic vesicles in the motor nerve terminals became transiently depleted.
J. Heuser, T. Reese
semanticscholar   +1 more source

Synaptic Transmission: Kinetics of synaptic-vesicle recycling [PDF]

Current Biology, 1995
The kinetics of different steps in synaptic-vesicle recycling, including exocytosis, internalization and repriming, have recently been estimated in various types of living cell.
Betz, William J., Wu, Ling-Gang
openaire   +2 more sources

Nonmuscle Myosin II helps regulate synaptic vesicle mobility at the Drosophila neuromuscular junction

BMC Neuroscience, 2010
Background Although the mechanistic details of the vesicle transport process from the cell body to the nerve terminal are well described, the mechanisms underlying vesicle traffic within nerve terminal boutons is relatively unknown.
Qiu Xinping, Seabrooke Sara, Stewart Bryan A   +2 more
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Activity-dependent plasticity of transmitter release from nerve terminals in rat fast and slow muscles [PDF]

, 2018
Available under a Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported license.Peer reviewedPublisher ...
Bewick, Guy Smith, Lomo, T., Martinov, V. N., Nja, A., Reid, Brian   +4 more
core   +1 more source

Age‐Related Characteristics of SYT1‐Associated Neurodevelopmental Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives We describe the clinical manifestations and developmental abilities of individuals with SYT1‐associated neurodevelopmental disorder (Baker‐Gordon syndrome) from infancy to adulthood. We further describe the neuroradiological and electrophysiological characteristics of the condition at different ages, and explore the associations ...
Sam G. Norwitz, Josefine Eck, Joel S. Winston, Kate Baker   +3 more
wiley   +1 more source

Transmitter release from cochlear hair cells is phase locked to cyclic stimuli of different intensities and frequencies [PDF]

, 2012
The auditory system processes time and intensity through separate brainstem pathways to derive spatial location as well as other salient features of sound.
Goutman, Juan Diego
core   +1 more source

Short term synaptic depression imposes a frequency dependent filter on synaptic information transfer. [PDF]

PLoS Computational Biology, 2012
Depletion of synaptic neurotransmitter vesicles induces a form of short term depression in synapses throughout the nervous system. This plasticity affects how synapses filter presynaptic spike trains. The filtering properties of short term depression are
Robert Rosenbaum, Jonathan Rubin, Brent Doiron   +2 more
doaj   +1 more source