Results 11 to 20 of about 74,511 (302)
PLoS ONE, 2014 Amyloid Precursor Protein (APP) is a type I membrane protein that undergoes extensive processing by secretases, including BACE1. Although mutations in APP and genes that regulate processing of APP, such as PSENs and BRI2/ITM2B, cause dementias, the ...
Dolores Del Prete +4 more
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Synaptic Vesicles Dynamics in Neocortical Epilepsy [PDF]
Frontiers in Cellular Neuroscience, 2020 Neuronal hyperexcitability often results from an unbalance between excitatory and inhibitory neurotransmission, but the synaptic alterations leading to enhanced seizure propensity are only partly understood.
Eleonora Vannini +8 more
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Mover is a homomeric phospho-protein present on synaptic vesicles.
PLoS ONE, 2013 With remarkably few exceptions, the molecules mediating synaptic vesicle exocytosis at active zones are structurally and functionally conserved between vertebrates and invertebrates. Mover was found in a yeast-2-hybrid assay using the vertebrate-specific
Saheeb Ahmed +9 more
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The GTPase Rab26 links synaptic vesicles to the autophagy pathway
eLife, 2015 Small GTPases of the Rab family not only regulate target recognition in membrane traffic but also control other cellular functions such as cytoskeletal transport and autophagy.
Beyenech Binotti +11 more
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MethodsX, 2021 Two types of secretory vesicles co-exist at some presynaptic terminals. Clear synaptic vesicles (CSV) release their contents at the synaptic active zone, upon single impulses, while dense-core vesicles (DCV) usually release their contents in the ...
Citlali Trueta
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The synaptic vesicle proteome [PDF]
Journal of Neurochemistry, 2007 AbstractSynaptic vesicles are key organelles in neurotransmission. Vesicle integral or membrane‐associated proteins mediate the various functions the organelle fulfills during its life cycle. These include organelle transport, interaction with the nerve terminal cytoskeleton, uptake and storage of low molecular weight constituents, and the regulated ...
Jacqueline, Burré, Walter, Volknandt
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Reduced expression of the vesicular acetylcholine transporter and neurotransmitter content affects synaptic vesicle distribution and shape in mouse neuromuscular junction. [PDF]
PLoS ONE, 2013 In vertebrates, nerve muscle communication is mediated by the release of the neurotransmitter acetylcholine packed inside synaptic vesicles by a specific vesicular acetylcholine transporter (VAChT).
Hermann A Rodrigues +8 more
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Synaptic Vesicle Endocytosis [PDF]
Cold Spring Harbor Perspectives in Biology, 2012 Neurons can sustain high rates of synaptic transmission without exhausting their supply of synaptic vesicles. This property relies on a highly efficient local endocytic recycling of synaptic vesicle membranes, which can be reused for hundreds, possibly thousands, of exo-endocytic cycles. Morphological, physiological, molecular, and genetic studies over
Yasunori, Saheki, Pietro, De Camilli
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Molecular Aspects of Secretory Granule Exocytosis by Neurons and Endocrine Cells [PDF]
, 1994 Neuronal communication and endocrine signaling are fundamental for integrating the function of tissues and cells in the body. Hormones released by endocrine cells are transported to the target cells through the circulation.
MANFRED GRATZL, Gratzl, Manfred
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F1000Research, 2017 Synaptic vesicle recycling is essential for sustained and reliable neurotransmission. A key component of synaptic vesicle recycling is the synaptic vesicle biogenesis process that is observed in synapses and that maintains the molecular identity of ...
Natali L. Chanaday, Ege T. Kavalali
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