Results 41 to 50 of about 354,036 (296)

Binding of Rab3A to Synaptic Vesicles [PDF]

Journal of Biological Chemistry, 2000
Prenylated Rab GTPases cycle between membrane-bound and soluble forms. Membrane-bound GDP-Rabs interact with GDP dissociation inhibitor (GDI), resulting in the dissociation of a Rab.GDI complex, which in turn serves as a precursor for the membrane re-association of Rabs. We have now characterized the binding of Rab3A to synaptic vesicles in vitro using
Chou, J., Jahn, R.
openaire   +3 more sources

Counting the Number of Glutamate Molecules in Single Synaptic Vesicles [PDF]

, 2019
Analytical tools for direct quantitative measurements of glutamate, the principal excitatory neurotransmitter in brain, are lacking. Here, we introduce a new enzyme-based amperometric sensor technique for direct counting of the number of glutamate ...
Hoda, fathali, Jacqueline, Keighron, karolina, skibicka, Ann-Sofie, Cans, Yuanmo, Wang, devesh, mishra, Thomas, Olsson   +6 more
core   +1 more source

T-cell trans-synaptic vesicles are distinct and carry greater effector content than constitutive extracellular vesicles [PDF]

, 2022
The immunological synapse is a molecular hub that facilitates the delivery of three activation signals, namely antigen, costimulation/corepression and cytokines, from antigen-presenting cells (APC) to T cells.
Valvo, Salvatore, Saliba, David G., Engledow, Simon, Aubert, Dimitri, Dustin, Michael L., Sezgin, Erdinc, Dushek, Omer, Attar, Moustafa, Fischer, Roman, Dustin, Michael L, Peng, Yanchun, Siller-Farfán, Jesús A., Céspedes, Pablo F., Fritzsche, Marco, Jainarayanan, Ashwin Kumar, Dong, Tao, Kvalvaag, Audun, Siller-Farfán, Jesús A, Céspedes, Pablo, Kurz, Elke, Fernández Messina, Lola María, Dustin, Michael, Saliba, David G, Ganskow, Charity, Jainarayanan, Ashwin, Céspedes, Pablo F, Colin-York, Huw, Peacock, Ben, Law, Alice, Chen, Lina, Saliba, David, Siller-Farfán, Jesús, Fernández-Messina, Lola, Sánchez-Madrid, Francisco, Johnson, Errin, Hester, Svenja   +35 more
core   +1 more source

In vitro fusion of single synaptic and dense core vesicles reproduces key physiological properties

Nature Communications, 2019
Regulated exocytosis of neuronal synaptic vesicles is substantially faster than that of endocrine dense core vesicles despite similar molecular machineries.
Alex J. B. Kreutzberger, Volker Kiessling, Christopher Stroupe, Binyong Liang, Julia Preobraschenski, Marcelo Ganzella, Mark A. B. Kreutzberger, Robert Nakamoto, Reinhard Jahn, J. David Castle, Lukas K. Tamm   +10 more
doaj   +1 more source

Synaptic Vesicles: An Organelle Comes of Age [PDF]

, 2006
Synaptic vesicles mediate the release of neurotransmitters at nerve terminals. In this issue of Cell, Takamori et al. (2006) analyze the lipid and protein components of synaptic vesicles, providing the most comprehensive description of synaptic vesicles ...
Südhof, Thomas C.
core   +1 more source

Long-Term Temporal Dynamics of Synaptic Vesicles [PDF]

, 2016
Neurotransmission requires the release of neurotransmitters from synaptic vesicles. This occurs via fusion of the vesicle to the pre-synaptic membrane upon stimulation.
Truckenbrodt, Sven
core   +1 more source

Recycling of Synaptic Vesicles

, 1997
Publisher Summary A widely accepted model describes the synaptic vesicle cycle as a modification of the receptor-mediated recycling pathway present in all cells. This pathway, by which cell surface receptors, like transferrin or low-density lipoprotein receptors, are internalized and recycled back to the surface, involves two distinct vesicular ...
R, Bauerfeind, C, David, D, Grabs, P S, McPherson, Y, Nemoto, V I, Slepnev, K, Takei, P, De Camilli   +7 more
openaire   +2 more sources

The Ca2+ sensor protein Swiprosin-1/EFhd2 is present in neurites and involved in kinesin-mediated transport in neurons [PDF]

, 2014
This work was supported by grants from the German Science Foundation (Deutsche Forschungsgemeinschaft, DFG; FOR832, to DM), the German Federal Ministry of Education and Research (01GQ113; to BW), the Bavarian Ministry of Sciences, Research and the Arts ...
Oliver Welzel, Böhm, Konrad J., Fritsch, K, Regensburger, M, Winner, B, Dirk Mielenz, Brachs, Sebastian, Regensburger, Martin, Francesc Perez-Branguli, Iryna Prots, Perez-Branguli , F, Eva Borger, Loy, Kristina, Brachs, S, Buslei, R, Wenzel, EM, Borger, Eva, Gromer, TW, Mielenz, Dirk, Max Holzer, Beate Winner, Kristina Loy, Holzer, M, Purohit, Pavitra, Holzer, Max, Purohit, P, Buslei, Rolf, Welzel, Oliver, Gunn-Moore, Frank J, Kristin Fritsch, Eva Maria Wenzel, Frank Gunn-Moore, Mielenz, D, Konrad J Böhm, Rolf Buslei, Loy, K, Teja W Grömer, Bohm, KJ, Fritsch, Kristin, Pavitra Purohit, Wenzel, Eva Maria, Prots, I, Perez-Branguli, Francesc, Gunn-Moore, Frank, Welzel, O, Prots, Iryna, Grömer, Teja W., Winner, Beate, Sebastian Brachs, Martin Regensburger   +49 more
core   +2 more sources

Incomplete vesicular docking limits synaptic strength under high release probability conditions

eLife, 2020
Central mammalian synapses release synaptic vesicles in dedicated structures called docking/release sites. It has been assumed that when voltage-dependent calcium entry is sufficiently large, synaptic output attains a maximum value of one synaptic ...
Gerardo Malagon, Takafumi Miki, Van Tran, Laura C Gomez, Alain Marty   +4 more
doaj   +1 more source

Spontaneous and evoked synaptic vesicle release arises from a single releasable pool

Cell Reports
Summary: The quantal content of an evoked postsynaptic response is typically determined by dividing it by the average spontaneous miniature response. However, this approach is challenged by the notion that different synaptic vesicle pools might drive ...
Junxiu Duan, Martin Kahms, Ana Steinhoff, Jürgen Klingauf   +3 more
doaj   +1 more source