Results 41 to 50 of about 74,688 (303)

Synaptic Vesicles: An Organelle Comes of Age [PDF]

, 2006
Synaptic vesicles mediate the release of neurotransmitters at nerve terminals. In this issue of Cell, Takamori et al. (2006) analyze the lipid and protein components of synaptic vesicles, providing the most comprehensive description of synaptic vesicles ...
Südhof, Thomas C.
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In vitro fusion of single synaptic and dense core vesicles reproduces key physiological properties

Nature Communications, 2019
Regulated exocytosis of neuronal synaptic vesicles is substantially faster than that of endocrine dense core vesicles despite similar molecular machineries.
Alex J. B. Kreutzberger, Volker Kiessling, Christopher Stroupe, Binyong Liang, Julia Preobraschenski, Marcelo Ganzella, Mark A. B. Kreutzberger, Robert Nakamoto, Reinhard Jahn, J. David Castle, Lukas K. Tamm   +10 more
doaj   +1 more source

Long-Term Temporal Dynamics of Synaptic Vesicles [PDF]

, 2016
Neurotransmission requires the release of neurotransmitters from synaptic vesicles. This occurs via fusion of the vesicle to the pre-synaptic membrane upon stimulation.
Truckenbrodt, Sven
core   +1 more source

Immunoisolation of GABA-Specific Synaptic Vesicles Defines a Functionally Distinct Subset of Synaptic Vesicles [PDF]

, 2000
Synaptic vesicles from mammalian brain are among the best characterized trafficking organelles. However, so far it has not been possible to characterize vesicle subpopulations that are specific for a given neurotransmitter. Taking advantage of the recent
Dietmar Riedel, Reinhard Jahn, Shigeo Takamori   +2 more
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Preparation of synaptic membranes and synaptic vesicles from rat brain. [PDF]

, 2013
A) Western blot for γ-secretase components and subcellular markers in the purification steps. synaptophysin (synaptic vesicles), PSD-95 (post-synaptic membrane), N-cadherin (plasma membrane), syntaxin13 (endosomes), γ-adaptin (trans-Golgi network), GM130
Mikio Aoki (367568), Lars O. Tjernberg (281204), Homira Behbahani (263564), Susanne Frykman (366239), Ji-Yeun Hur (367567), Bengt Winblad (281202), Jarmila Nahalkova (367569), Jenny Frånberg (366235)   +7 more
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Exploring the functional domain and the target of the tetanus toxin light chain in neurohypophysial terminals [PDF]

, 1994
The tetanus toxin light chain blocks calcium induced vasopressin release from neurohypophysial nerve terminals. Here we show that histidine residue 233 within the putative zinc binding motif of the tetanus toxin light chain is essential for the ...
Weller, U., Dayanithi, G., Yamasaki, S., Niemann, H., Gratzl, Manfred, Stecher, B., Höhne-Zell, B., Binz, T.   +7 more
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Secretory vesicles are preferentially targeted to areas of low molecular SNARE density [PDF]

, 2012
Intercellular communication is commonly mediated by the regulated fusion, or exocytosis, of vesicles with the cell surface. SNARE (soluble N-ethymaleimide sensitive factor attachment protein receptor) proteins are the catalytic core of the secretory ...
Weiping Lu (120665), Dun, Alison R., Lu, Weiping, Rory R. Duncan (120667), Weiping Lu, Gabriel J. Lord (120664), Colin Rickman (120669), Andrew Dunn, Gabriel J Lord, Martin, Kirsty J, Lei Yang (102719), Qiu, Zhen, Rickman, Colin; id_orcid, Kirsty J Martin, Lei Yang, Duncan, Rory R, Duncan, Rory R., Alison R. Dun (120660), Zhen Qiu (120662), Rickman, Colin, Dun, Alison, Qiu, Zhen; id_orcid, Colin Rickman, Rory R Duncan, Lord, Gabriel J, Kirsty J. Martin (120661), Alison R Dun, Lord, Gabriel J., Yang, Lei, Martin, Kirsty J., Andrew Dunn (120663), Dunn, Andrew, Zhen Qiu   +32 more
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Spontaneous and evoked synaptic vesicle release arises from a single releasable pool

Cell Reports
Summary: The quantal content of an evoked postsynaptic response is typically determined by dividing it by the average spontaneous miniature response. However, this approach is challenged by the notion that different synaptic vesicle pools might drive ...
Junxiu Duan, Martin Kahms, Ana Steinhoff, Jürgen Klingauf   +3 more
doaj   +1 more source

The Ca2+ sensor protein Swiprosin-1/EFhd2 is present in neurites and involved in kinesin-mediated transport in neurons [PDF]

, 2014
This work was supported by grants from the German Science Foundation (Deutsche Forschungsgemeinschaft, DFG; FOR832, to DM), the German Federal Ministry of Education and Research (01GQ113; to BW), the Bavarian Ministry of Sciences, Research and the Arts ...
Oliver Welzel, Böhm, Konrad J., Fritsch, K, Regensburger, M, Winner, B, Dirk Mielenz, Brachs, Sebastian, Regensburger, Martin, Francesc Perez-Branguli, Iryna Prots, Perez-Branguli , F, Eva Borger, Loy, Kristina, Brachs, S, Buslei, R, Wenzel, EM, Borger, Eva, Gromer, TW, Mielenz, Dirk, Max Holzer, Beate Winner, Kristina Loy, Holzer, M, Purohit, Pavitra, Holzer, Max, Purohit, P, Buslei, Rolf, Welzel, Oliver, Gunn-Moore, Frank J, Kristin Fritsch, Eva Maria Wenzel, Frank Gunn-Moore, Mielenz, D, Konrad J Böhm, Rolf Buslei, Loy, K, Teja W Grömer, Bohm, KJ, Fritsch, Kristin, Pavitra Purohit, Wenzel, Eva Maria, Prots, I, Perez-Branguli, Francesc, Gunn-Moore, Frank, Welzel, O, Prots, Iryna, Grömer, Teja W., Winner, Beate, Sebastian Brachs, Martin Regensburger   +49 more
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Incomplete vesicular docking limits synaptic strength under high release probability conditions

eLife, 2020
Central mammalian synapses release synaptic vesicles in dedicated structures called docking/release sites. It has been assumed that when voltage-dependent calcium entry is sufficiently large, synaptic output attains a maximum value of one synaptic ...
Gerardo Malagon, Takafumi Miki, Van Tran, Laura C Gomez, Alain Marty   +4 more
doaj   +1 more source