Results 61 to 70 of about 119,730 (299)

Synaptic vesicle-omics in mice captures signatures of aging and synucleinopathy

Nature Communications
Neurotransmitter release occurs through exocytosis of synaptic vesicles. α-Synuclein’s function and dysfunction in Parkinson’s disease and other synucleinopathies is thought to be tightly linked to synaptic vesicle binding. Age is the biggest risk factor
Virginia Gao, Julita Chlebowicz, Karlton Gaskin, Juan A. Briano, Lauren E. Komer, André Pineda, Shrey Jhalani, Saad Ahmad, Eseosa Uwaifo, Luca S. Black, Jillian E. Haller, Serge Przedborski, Diane A. Lane, Sheng Zhang, Manu Sharma, Jacqueline Burré   +15 more
doaj   +1 more source

Synaptic Vesicles Dynamics in Neocortical Epilepsy

Frontiers in Cellular Neuroscience, 2020
Neuronal hyperexcitability often results from an unbalance between excitatory and inhibitory neurotransmission, but the synaptic alterations leading to enhanced seizure propensity are only partly understood.
Eleonora Vannini, Eleonora Vannini, Eleonora Vannini, Laura Restani, Marialaura Dilillo, Liam A. McDonnell, Matteo Caleo, Matteo Caleo, Vincenzo Marra   +8 more
doaj   +1 more source

A Systematic Comparison of Alpha‐Synuclein Seed Amplification Assays for Increasing Reproducibility

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Seed amplification assays (SAAs) enable ultrasensitive detection of misfolded α‐synuclein across biofluids and tissues. Yet, heterogeneity in protocols limits cross‐study comparability and clinical translation. Here, we review α‐synuclein SAA methods and their performance across various biological matrices.
Manuela Amaral‐do‐Nascimento, Daniela F. Santos, Tuane C. R. G. Vieira, Tiago F. Outeiro   +3 more
wiley   +1 more source

The GTPase Rab26 links synaptic vesicles to the autophagy pathway

eLife, 2015
Small GTPases of the Rab family not only regulate target recognition in membrane traffic but also control other cellular functions such as cytoskeletal transport and autophagy.
Beyenech Binotti, Nathan J Pavlos, Dietmar Riedel, Dirk Wenzel, Gerd Vorbrüggen, Amanda M Schalk, Karin Kühnel, Janina Boyken, Christian Erck, Henrik Martens, John JE Chua, Reinhard Jahn   +11 more
doaj   +1 more source

Research progress on vesicle cycle and neurological disorders

Journal of Pharmacy & Pharmaceutical Sciences, 2021
Neurons are special polarized cells whose synaptic vesicles release neurotransmitters into the synaptic cleft, acting on postsynaptic receptors and thus transmitting information from presynaptic to postsynaptic states.
Chengcheng Zhang, Li-Juan Zhu, Ce Chen
doaj   +1 more source

Bio‐Inspired Molecular Events in Poly(Ionic Liquids)

Advanced Functional Materials, EarlyView.
Originating from dipolar and polar inter‐ and intra‐chain interactions of the building blocks, the topologies and morphologies of poly(ionic liquids) (PIL) govern their nano‐ and micro‐processibility. Modulating the interactions of cation‐anion pairs with aliphatic dipolar components enables the tunability of properties, facilitated by “bottom‐up ...
Jiahui Liu, Marek W. Urban
wiley   +1 more source

Photoreceptor Outer Segment-like Structures in Long-Term 3D Retinas from Human Pluripotent Stem Cells. [PDF]

, 2017
The retinal degenerative diseases, which together constitute a leading cause of hereditary blindness worldwide, are largely untreatable. Development of reliable methods to culture complex retinal tissues from human pluripotent stem cells (hPSCs) could ...
Angueyra, Juan M, Ball, John, Grebe, Rhonda, Jones, Bryan W, Kim, Catherine, Li, Wei, Maruotti, Julien A, Sripathi, Srinivasa R, Wahlin, Karl J, Zack, Donald J   +9 more
core   +1 more source

Bioactive Conductive Ti3C2Tx‐Ce Hydrogel Facilitates Spinal Cord Injury Repair Through ROS Scavenging and Mitochondrial Regulation

Advanced Functional Materials, EarlyView.
Bioactive conductive Ti3C2Tx‐Ce hydrogels with with scavenging ROS and alleviating neuronal mitochondrial dysfunction are exploited for SCI treatment. This functionality is attributed to interfacial activation modification of Ti3C2Tx with Ce3+ ions to in‐situ form Ce(OH)x‐mediated protective layer, which is beneficial to enabling stable intracellular ...
Weikang Wang, Qing Liu, Ang Lv, Yabin Lin, Jiawei Chen, Ning Ding, Chunlei Zhang, Shuai Zhou, Bo Yuan, Weiwei Zhao, Liming Li, Luping Zhang, Fei Huang   +12 more
wiley   +1 more source

Differential expression of synaptophysin and synaptoporin during pre- and postnatal development of the hippocampal network [PDF]

, 1994
The closely related synaptic vesicle membrane proteins synaptophysin and synaptoporin are abundant in the hippocampal formation of the adult rat. But the prenatal hippocampal formation contains only synaptophysin, which is first detected at embryonic day
Amaral, Assaf, Bayer, Bergmann, Bergmann, Betz, Blackstad, Blasi, Bliss, Cameron, Crawford, D. Grabs, Dyck, Feany, Frotscher, Fykse, Haug, Hollmann, Howell, Hsu, Jahn, Jahn, Johnston, Johnston, Knaus, Laemmli, Lah, Lahr, Linstedt, Linstedt, M. Bergmann, M. Brich, M. Gratzl, Marquèze-Pouey, Mundigl, O'Connor, Ovtscharoff, Oyler, P. A. Fox, Règnier-Vigouroux, Scarfone, Schiavo, Schilling, Schmied, Slomianka, Sloviter, Söllner, Th. Schuster, Thomas, Towbin, Westbrook, Zimmer   +51 more
core   +1 more source

Small Extracellular Vesicles from Neural Cells: Physiological and Pathological Roles, and Potential in Neurodegenerative Therapy

Advanced Healthcare Materials, EarlyView.
Neural cell–derived small extracellular vesicles (sEVs) are emerging as pivotal mediators in neurodegenerative diseases, exerting both pathogenic and therapeutic functions. This review synthesizes current evidence on how sEVs from distinct neural cell types regulate neurodegeneration, neuroprotection, biomarker discovery, and targeted drug delivery ...
Muhammad Waqas Salim, Wei Zhang, Lyndsey Collins‐Praino, Yuling Wang, Andrew Care   +4 more
wiley   +1 more source