Results 71 to 80 of about 119,730 (299)

Use of fluorescent probes to follow membrane traffic in nerve terminals

Brazilian Journal of Medical and Biological Research, 1998
Optical tracers in conjunction with fluorescence microscopy have become widely used to follow the movement of synaptic vesicles in nerve terminals. The present review discusses the use of these optical methods to understand the regulation of exocytosis ...
Guatimosim C., Romano-Silva M.A., Gomez M.V., Prado M.A.M.   +3 more
doaj  

Medial Superior Olivary Neurons Receive Surprisingly Few Excitatory and Inhibitory Inputs with Balanced Strength and Short-Term Dynamics [PDF]

, 2010
Neurons in the medial superior olive (MSO) process microsecond interaural time differences, the major cue for localizing low-frequency sounds, by comparing the relative arrival time of binaural, glutamatergic excitatory inputs. This coincidence detection
Couchman, Kiri, Felmy, Felix, Grothe, Benedikt   +2 more
core   +2 more sources

Mapping the Cerebral Organoid Landscape: A Systematic Review of Preclinical 3D Models in Neuroscience

Advanced Healthcare Materials, EarlyView.
Cerebral organoids are transforming brain research, yet the field remains fragmented. This comprehensive systematic review maps 738 studies published between 2014 and 2024 to uncover trends, gaps, and opportunities across neuroscience. Introducing OrganoidMap—an interactive, open‐access platform to explore and compare models—this work enables ...
Anna Wolfram, Vanessa Arnold, Maik Wolfram‐Schauerte, Anastassiya Moskalchuk, Caroline Trust, Marie Vontz, Mona Scheurenbrand, Vijayasarathy Sampath‐Kumar, Sogand Ahari, Carlos Romero‐Nieto, Lisa Sevenich   +10 more
wiley   +1 more source

VGLUT1 functions as a glutamate/proton exchanger with chloride channel activity in hippocampal glutamatergic synapses

Nature Communications, 2017
During neurotransmission synaptic vesicles are filled with glutamate by vesicular glutamate transporters (VGLUTs). Here, authors image intact neurons and show that in synaptic vesicles VGLUT functions as a glutamate/proton exchanger associated with a ...
Magalie Martineau, Raul E. Guzman, Christoph Fahlke, Jürgen Klingauf   +3 more
doaj   +1 more source

Involvement of ClC-3 chloride/proton exchangers in controlling glutamatergic synaptic strength in cultured hippocampal neurons

Frontiers in Cellular Neuroscience, 2014
ClC-3 is a member of the CLC family of anion channels and transporters that localizes to early and late endosomes as well as to synaptic vesicles. Its genetic disruption in mouse models results in pronounced hippocampal and retinal neurodegeneration ...
Raul Enrique Guzman, Alexi eAlekov, Mikhail eFilippov, Mikhail eFilippov, Jan eHegermannd, Christoph eFahlke   +5 more
doaj   +1 more source

Research progress on the role of type I vesicular glutamate transporter (VGLUT1) in nervous system diseases

Cell & Bioscience, 2020
Glutamate (Glu) is the predominant excitatory neurotransmitter in the central nervous system (CNS). Glutamatergic transmission is critical for controlling neuronal activity.
Xianchao Du, Jiashuo Li, Minghui Li, Xinxin Yang, Zhipeng Qi, Bin Xu, Wei Liu, Zhaofa Xu, Yu Deng   +8 more
doaj   +1 more source

Ontogeny of synaptophysin and synaptoporin in the central nervous system [PDF]

, 1993
The expression of the synaptic vesicle antigens synaptophysin (SY) and synaptoporin (SO) was studied in the rat striatum, which contains a nearly homogeneous population of GABAergic neurons. In situ hybridization revealed high levels of SY transcripts in
B. Marquèze-Pouey, Bergmann, Betz, D. Grabs, Goldman-Rakic, Graybiel, H. Betz, Heimer, Hsu, I. Reisert, Iñiguez, Jahn, Jahn, Kita, Knaus, Lahr, Lauder, Leube, Lindefors, M. Bergmann, M. Gratzl, Marquèze-Pouey, Mugnaini, Newman-Gage, Olson, P. Knaus, Reiner, Reisert, Smith, Specht, Specht, Südhof, Thomas, Vernier, W. Ovtscharoff, Wiedenmann, Wilson   +36 more
core   +1 more source

Designed Liquid Crystalline Nanoassemblies From Clinically Validated Polyunsaturated Lipids for Combined Antioxidant, Anti‐Apoptotic, and Neurotrophic Treatments

Advanced Healthcare Materials, EarlyView.
Ionizable lipid nanoparticles target multiple pathological pathways in neurodegeneration. The designed self‐assembled materials undergo a pH‐triggered structural transformation from a cubosome/hexosome coexistence to a hexosome phase, enhancing intracellular delivery of a multi‐target phytochemical formulation. The antioxidant‐loaded pH‐responsive LNPs
Thelma Akanchise, Fucen Luo, Borislav Angelov, Yuru Deng, Angelina Angelova   +4 more
wiley   +1 more source

Histamine synthesis and transport are coupled in axon terminals via a dual quality control system

The EMBO Journal
Monoamine neurotransmitters generated by de novo synthesis are rapidly transported and stored into synaptic vesicles at axon terminals. This transport is essential both for sustaining synaptic transmission and for limiting the toxic effects of monoamines.
Lei Peng, Tao Wang
doaj   +1 more source

LOVIT Is a Putative Vesicular Histamine Transporter Required in Drosophila for Vision

Cell Reports, 2019
Summary: Classical fast neurotransmitters are loaded into synaptic vesicles and concentrated by the action of a specific vesicular transporter before being released from the presynaptic neuron.
Ying Xu, Tao Wang
doaj   +1 more source