Results 71 to 80 of about 74,511 (302)
Use of fluorescent probes to follow membrane traffic in nerve terminals
Brazilian Journal of Medical and Biological Research, 1998 Optical tracers in conjunction with fluorescence microscopy have become widely used to follow the movement of synaptic vesicles in nerve terminals. The present review discusses the use of these optical methods to understand the regulation of exocytosis ...
Guatimosim C. +3 more
doaj
Nature Communications, 2017 During neurotransmission synaptic vesicles are filled with glutamate by vesicular glutamate transporters (VGLUTs). Here, authors image intact neurons and show that in synaptic vesicles VGLUT functions as a glutamate/proton exchanger associated with a ...
Magalie Martineau +3 more
doaj +1 more source
Frontiers in Cellular Neuroscience, 2014 ClC-3 is a member of the CLC family of anion channels and transporters that localizes to early and late endosomes as well as to synaptic vesicles. Its genetic disruption in mouse models results in pronounced hippocampal and retinal neurodegeneration ...
Raul Enrique Guzman +5 more
doaj +1 more source
Preparation of synaptic membranes and synaptic vesicles from rat brain.
, 2013 A) Western blot for γ-secretase components and subcellular markers in the purification steps. synaptophysin (synaptic vesicles), PSD-95 (post-synaptic membrane), N-cadherin (plasma membrane), syntaxin13 (endosomes), γ-adaptin (trans-Golgi network), GM130
Mikio Aoki (367568) +7 more
core +1 more source
Synaptic vesicles in the fast lane [PDF]
, 2004 It is well established that a subset of synaptic vesicles seem to be preferentially recycled after neurotransmitter release. It has been assumed that these vesicles must cluster at the active zones of the presynaptic nerve terminal membrane so that they ...
Jahn, R. +3 more
core +1 more source
Advanced Science, EarlyView.We uncover a large variety of putative inhibitory ligand‐gated ion channels (LGICs) in the phylum Cnidaria, the sister group to all bilaterian animals. Phylogenetic analysis suggests a complex evolutionary history of inhibitory LGICs with diverse neurotransmitter ligands.
Abhilasha Ojha +13 more
wiley +1 more source
LOVIT Is a Putative Vesicular Histamine Transporter Required in Drosophila for Vision
Cell Reports, 2019 Summary: Classical fast neurotransmitters are loaded into synaptic vesicles and concentrated by the action of a specific vesicular transporter before being released from the presynaptic neuron.
Ying Xu, Tao Wang
doaj +1 more source
Current Biology, 1999 Thomas Sudhof, Pietro De Camilli, Reinhard Jahn and Richard Scheller, to name but a few. Although the competitive, fast-paced nature of the field means you're unlikely to find them all in the same room at the same time.
openaire +2 more sources
Advanced Science, EarlyView.Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng +8 more
wiley +1 more source
Histamine synthesis and transport are coupled in axon terminals via a dual quality control system
The EMBO JournalMonoamine neurotransmitters generated by de novo synthesis are rapidly transported and stored into synaptic vesicles at axon terminals. This transport is essential both for sustaining synaptic transmission and for limiting the toxic effects of monoamines.
Lei Peng, Tao Wang
doaj +1 more source