Results 71 to 80 of about 74,688 (303)

Aberrant location of inhibitory synaptic marker proteins in the hippocampus of dystrophin-deficient mice [PDF]

, 2014
Duchenne muscular dystrophy (DMD) is a neuromuscular disease that arises from mutations in the dystrophin-encoding gene. Apart from muscle pathology, cognitive impairment, primarily of developmental origin, is also a significant component of the disorder.
Zablocki, Krzysztof, Elżbieta Krasowska, Krasowska Elżbieta, Gorecki, Dariusz C., Swinny, Jerome D., Dariusz C Górecki, Swinny Jerome D., Zabłocki Krzysztof, Jerome D Swinny, Krasowska, Elzbieta, Górecki Dariusz C., Krzysztof Zabłocki   +11 more
core   +1 more source

Trans-synaptic assemblies link synaptic vesicles and neuroreceptors [PDF]

, 2021
Synaptic transmission is characterized by fast, tightly coupled processes and complex signaling pathways that require a precise protein organization, such as the previously reported nanodomain colocalization of pre- and postsynaptic proteins.
Baumeister, Wolfgang, Martínez Sánchez, Antonio, Zinzula, L., Baumeister, W., Kochovski, Z., Papantoniou, C., Lučić, Vladan, Lucic, V., Papantoniou, Christos, Martinez-Sanchez, Antonio, Kochovski, Zdravko, Laugks, U., Zinzula, Luca, Martinez Sanchez, A., Laugks, Ulrike   +14 more
core   +2 more sources

Mitigating Cancer Therapy–Related Cognitive Impairment by Targeted Activation of Undruggable Phosphatase

Advanced Science, EarlyView.
An RVG‑engineered exosomal saRNA delivery system (RVG‑EVs‑saPtpro) effectively targets and activates hippocampal PTPRO, functioning as a “molecular brake” to alleviate cancer therapy‑related cognitive impairment (CTRCI) by enhancing neuronal survival, neurogenesis, and synaptic plasticity.
Zhimeng Yao, Yuhua Meng, Huanyi Li, Yinhui Jiang, Xiaona Lin, Mengyuan Hu, Qing Liu, Xiaofu Qiu, Hongzheng Ren, Yunlong Pan, Bin Pan, Zexiong Guo, Shuyao Zhang, Dianzheng Zhang, Li Yang, Shegan Gao, Weijing Deng, Jianfan Chen, Hao Zhang   +18 more
wiley   +1 more source

Use of fluorescent probes to follow membrane traffic in nerve terminals

Brazilian Journal of Medical and Biological Research, 1998
Optical tracers in conjunction with fluorescence microscopy have become widely used to follow the movement of synaptic vesicles in nerve terminals. The present review discusses the use of these optical methods to understand the regulation of exocytosis ...
Guatimosim C., Romano-Silva M.A., Gomez M.V., Prado M.A.M.   +3 more
doaj  

VGLUT1 functions as a glutamate/proton exchanger with chloride channel activity in hippocampal glutamatergic synapses

Nature Communications, 2017
During neurotransmission synaptic vesicles are filled with glutamate by vesicular glutamate transporters (VGLUTs). Here, authors image intact neurons and show that in synaptic vesicles VGLUT functions as a glutamate/proton exchanger associated with a ...
Magalie Martineau, Raul E. Guzman, Christoph Fahlke, Jürgen Klingauf   +3 more
doaj   +1 more source

Involvement of ClC-3 chloride/proton exchangers in controlling glutamatergic synaptic strength in cultured hippocampal neurons

Frontiers in Cellular Neuroscience, 2014
ClC-3 is a member of the CLC family of anion channels and transporters that localizes to early and late endosomes as well as to synaptic vesicles. Its genetic disruption in mouse models results in pronounced hippocampal and retinal neurodegeneration ...
Raul Enrique Guzman, Alexi eAlekov, Mikhail eFilippov, Mikhail eFilippov, Jan eHegermannd, Christoph eFahlke   +5 more
doaj   +1 more source

Research progress on the role of type I vesicular glutamate transporter (VGLUT1) in nervous system diseases

Cell & Bioscience, 2020
Glutamate (Glu) is the predominant excitatory neurotransmitter in the central nervous system (CNS). Glutamatergic transmission is critical for controlling neuronal activity.
Xianchao Du, Jiashuo Li, Minghui Li, Xinxin Yang, Zhipeng Qi, Bin Xu, Wei Liu, Zhaofa Xu, Yu Deng   +8 more
doaj   +1 more source

Synaptic Vesicle Pools and Dynamics [PDF]

Cold Spring Harbor Perspectives in Biology, 2012
Synaptic vesicles release neurotransmitter at chemical synapses, thus initiating the flow of information in neural networks. To achieve this, vesicles undergo a dynamic cycle of fusion and retrieval to maintain the structural and functional integrity of the presynaptic terminals in which they reside.
AbdulRasheed A, Alabi, Richard W, Tsien
openaire   +2 more sources

Enhancing Maturation of Human Neuromuscular Organoids via Electrical Stimulation

Advanced Science, EarlyView.
A framework for on‐demand and non‐invasive exposure of human neuromuscular organoids (NMOs) to electrical stimuli is established to promote their maturation. The robustness and effectiveness of different stimulation regimes are evaluated via thorough characterization of organoid tissue structure and contraction capacity. Chronic electrical stimulation,
Chrysanthi‐Maria Moysidou, Inês Afonso Martins, Ismail Amr El‐Shimy, Iacopo Bicci, Donatella Cea, Christina Bukas, Isra Mekki, Mara‐Camelia Rusu, Aylin Nebol, Ines Lahmann, Marie Piraud, Enrico Klotzsch, Mina Gouti   +12 more
wiley   +1 more source

Synaptic vesicles in the fast lane [PDF]

, 2004
It is well established that a subset of synaptic vesicles seem to be preferentially recycled after neurotransmitter release. It has been assumed that these vesicles must cluster at the active zones of the presynaptic nerve terminal membrane so that they ...
Jahn, R., Jahn, Reinhard, Holt, Matthew, Holt, M.   +3 more
core   +1 more source