Results 81 to 90 of about 354,036 (296)

LOVIT Is a Putative Vesicular Histamine Transporter Required in Drosophila for Vision

Cell Reports, 2019
Summary: Classical fast neurotransmitters are loaded into synaptic vesicles and concentrated by the action of a specific vesicular transporter before being released from the presynaptic neuron.
Ying Xu, Tao Wang
doaj   +1 more source

Preparation of synaptic membranes and synaptic vesicles from rat brain.

, 2013
A) Western blot for γ-secretase components and subcellular markers in the purification steps. synaptophysin (synaptic vesicles), PSD-95 (post-synaptic membrane), N-cadherin (plasma membrane), syntaxin13 (endosomes), γ-adaptin (trans-Golgi network), GM130
Mikio Aoki (367568), Lars O. Tjernberg (281204), Homira Behbahani (263564), Susanne Frykman (366239), Ji-Yeun Hur (367567), Bengt Winblad (281202), Jarmila Nahalkova (367569), Jenny Frånberg (366235)   +7 more
core   +1 more source

MSK1 regulates homeostatic and experience-dependent synaptic plasticity [PDF]

, 2012
The ability of neurons to modulate synaptic strength underpins synaptic plasticity, learning and memory, and adaptation to sensory experience. Despite the importance of synaptic adaptation in directing, reinforcing, and revising the behavioral response ...
Frenguelli, BrunoG., Corrêa, SAL, McKenzie, Colin, Palygin, O, Palygin, Oleg, Martin, KJ, Arthur, J.S., McKelvey, Kim, Hunter, CJ, Morris, R. G. M. (Richard G. M.), Morris, R.G., Morris, RGM, McKenzie, C, Hunter, Christopher J., Wauters, Sandrine C., Pankratov, Yuriy, Hunter, C.J., Wauters, S.C., Wauters, SC, Wauters, Sandrine, Martin, K.J., Arthur, J.Simon C.; id_orcid, Palygin, O., Frenguelli, BG, Corrêa, Sonia A.L., Corrêa, Sônia A. L., Arthur, J. Simon C., Frenguelli, Bruno G., Morris, Richard G. M., Frenguelli, B.G., Pankratov, Y., Martin, Kirsty J., McKelvey, Kim M. (Kim Martin), McKenzie, C., Arthur, JSC, McKelvey, K., Pankratov, Y, McKelvey, K   +37 more
core   +1 more source

Bottom‐Up Engineering of a Human Neuromuscular System for Modeling Activity‐Induced Remodeling, Metabolic Stress, and Endothelial‐Modulated Excitability

Advanced Materials, EarlyView.
Using a bottom‐up approach, we engineered a human neuromuscular microchip to investigate distinct adaptive responses to neural stimulation and metabolic stress. Further integration of endothelial cells revealed their critical role in modulating neuromuscular excitability, establishing a comprehensive neurovascular‐muscular model.
Jinchul Ahn, Min‐seop Kim, Ju‐Hee Kim, Seok‐Hyeon Kang, Dain Lee, Hui‐Wen Liu, Seung‐cheol Shin, Kyuhwan Na, Yesl Jun, Oak‐Kee Hong, Ji Hun Yang, Jin‐A Kim, Hwanseok Jang, Hong Nam Kim, Roger D. Kamm, Ji‐Hoon Kim, Jang‐Won Son, Seok Chung   +17 more
wiley   +1 more source

The readily-releasable pool dynamically regulates multivesicular release

eLife, 2019
The number of neurotransmitter-filled vesicles released into the synaptic cleft with each action potential dictates the reliability of synaptic transmission.
Jada H Vaden, Gokulakrishna Banumurthy, Eugeny S Gusarevich, Linda Overstreet-Wadiche, Jacques I Wadiche   +4 more
doaj   +1 more source

Synaptic vesicle proteins

Current Biology, 1999
Thomas Sudhof, Pietro De Camilli, Reinhard Jahn and Richard Scheller, to name but a few. Although the competitive, fast-paced nature of the field means you're unlikely to find them all in the same room at the same time.
openaire   +2 more sources

Immunoisolation of GABA-Specific Synaptic Vesicles Defines a Functionally Distinct Subset of Synaptic Vesicles

, 2000
Synaptic vesicles from mammalian brain are among the best characterized trafficking organelles. However, so far it has not been possible to characterize vesicle subpopulations that are specific for a given neurotransmitter. Taking advantage of the recent
Dietmar Riedel, Reinhard Jahn, Shigeo Takamori   +2 more
core   +1 more source

Innate Immunocompetent hiPSC‐Derived Neurospheroids Capture Early CNS Responses to rAAV

Advanced Science, EarlyView.
Knowledge of human CNS immune responses to AAV‐based gene therapies remains limited due to the lack of immune‐competent human models. Here, a hiPSC‐derived 3D neuroimmune platform integrating neurospheroids and microglia is established using stirred‐tank bioreactors.
Catarina M. Gomes, Gabriela Silva, Mafalda Aleixo, Marta Gomes, Daniel Simão, Stephan J. Holtkamp, Diana D. Lobo, Pradeep Harish, Rosalind Jenkins, Lekh N. Dahal, Rui J. Nobre, Luís de Pereira de Almeida, Mark Trautwein, Paula M. Alves, Catarina Brito   +14 more
wiley   +1 more source

Synaptic Ribbons Require Ribeye for Electron Density, Proper Synaptic Localization, and Recruitment of Calcium Channels

Cell Reports, 2016
Synaptic ribbons are structures made largely of the protein Ribeye that hold synaptic vesicles near release sites in non-spiking cells in some sensory systems.
Caixia Lv, William J. Stewart, Otar Akanyeti, Courtney Frederick, Jie Zhu, Joseph Santos-Sacchi, Lavinia Sheets, James C. Liao, David Zenisek   +8 more
doaj   +1 more source

Regulation of synaptic vesicle docking by different classes of macromolecules in active zone material. [PDF]

PLoS ONE, 2012
The docking of synaptic vesicles at active zones on the presynaptic plasma membrane of axon terminals is essential for their fusion with the membrane and exocytosis of their neurotransmitter to mediate synaptic impulse transmission.
Joseph A Szule, Mark L Harlow, Jae Hoon Jung, Francisco F De-Miguel, Robert M Marshall, Uel J McMahan   +5 more
doaj   +1 more source