Results 81 to 90 of about 74,688 (303)

Single-Molecule Imaging of Recycling Synaptic Vesicles in Live Neurons [PDF]

, 2020
The capacity of neurons to communicate and store information in the brain critically depends on neurotransmission, a process which relies on the release of chemicals called neurotransmitters stored in synaptic vesicles at the presynaptic nerve terminals.
Mollazade, Mahdie, Martínez-Mármol, Ramon, Joensuu, Merja, Mahdie Mollazade, Pranesh Padmanabhan, Ramon Martínez-Mármol, Padmanabhan, Pranesh, Merja Joensuu, Meunier, Frédéric A., Frédéric A. Meunier   +9 more
core   +1 more source

LOVIT Is a Putative Vesicular Histamine Transporter Required in Drosophila for Vision

Cell Reports, 2019
Summary: Classical fast neurotransmitters are loaded into synaptic vesicles and concentrated by the action of a specific vesicular transporter before being released from the presynaptic neuron.
Ying Xu, Tao Wang
doaj   +1 more source

Synaptic vesicle proteins

Current Biology, 1999
Thomas Sudhof, Pietro De Camilli, Reinhard Jahn and Richard Scheller, to name but a few. Although the competitive, fast-paced nature of the field means you're unlikely to find them all in the same room at the same time.
openaire   +2 more sources

Astrocytic Phenotypic Switching in Posterior Piriform Cortex Orchestrates Bone Cancer Pain–Depression Comorbidity via Purinergic–Noradrenergic Signaling

Advanced Science, EarlyView.
Bone cancer pain and depression share a common origin: astrocytic A2‐to‐A1 transition in the posterior piriform cortex. This phenotypic shift disrupts the ATP–adenosine–A2AR–norepinephrine axis, simultaneously driving nociceptive and affective dysfunction.
Jiang‐Ping Liu, Jun‐Han Zhang, Zhi‐Xuan Tan, Wei‐Bing Yan, Ya‐Ru Yuan, Yao Liu, Bing‐Di Wei, Meng‐Qi Ding, Zhuo‐Min Fu, Ying Liu, An‐Qi Wang, Lin Ma, Yong‐Hong Li, Er‐Qing Chai, Chao‐Jun Wei   +14 more
wiley   +1 more source

Histamine synthesis and transport are coupled in axon terminals via a dual quality control system

The EMBO Journal
Monoamine neurotransmitters generated by de novo synthesis are rapidly transported and stored into synaptic vesicles at axon terminals. This transport is essential both for sustaining synaptic transmission and for limiting the toxic effects of monoamines.
Lei Peng, Tao Wang
doaj   +1 more source

The readily-releasable pool dynamically regulates multivesicular release

eLife, 2019
The number of neurotransmitter-filled vesicles released into the synaptic cleft with each action potential dictates the reliability of synaptic transmission.
Jada H Vaden, Gokulakrishna Banumurthy, Eugeny S Gusarevich, Linda Overstreet-Wadiche, Jacques I Wadiche   +4 more
doaj   +1 more source

BIN1 and ALDH1B1 Deficiency in Colonic Smooth Muscle Drives Mitochondrial Dysfunction and Fibrosis in Slow‐Transit Constipation

Advanced Science, EarlyView.
Slow‐transit constipation (STC) is a disabling motility disorder with unclear smooth‐muscle mechanisms. Spatial proteomic analysis of STC patient colon reveals both the central pathogenic role of smooth muscle cells (SMCs) in STC and novel regulators of intestinal motility, BIN1 and ALDH1B1.
Jianbo Liu, Hao Zhang, Wenhao Qiao, Ran Liu, Jie Sun, Xiaopei Li, Qin Li, Dongbo Zhao, Dawei Chen, Jingxin Li, Shuxiao Dong   +10 more
wiley   +1 more source

FM1-43 reveals membrane recycling in adult inner hair cells of the mammalian cochlea [PDF]

, 2002
Neural transmission of complex sounds demands fast and sustained rates of synaptic release from the primary cochlear receptors, the inner hair cells (IHCs). The cells therefore require efficient membrane recycling.
Ashmore, JF, Griesinger, CB, Richards, CD   +2 more
core  

Association of N-ethylmaleimide-sensitive factor with synaptic vesicles [PDF]

, 1994
N-Ethylmaleimide-sensitive factor (NSF) mediates docking and/or fusion of transport vesicles in the multi-pathways of vesicular transport. NSF was highly expressed in brain and adrenal gland.
Rong-Mao Hong, Akitsugu Yamamoto, Futai, Masamitsu, Yutaka Tashiro, Yamamoto, Akitsugu, Masamitsu Futai, Tashiro, Yutaka, Mitsuo Tagaya, Yoshinori Moriyama, Moriyama, Yoshinori, Hiroyuki Mori, Tagaya, Mitsuo, Hong, Rong-Mao, Mori, Hiroyuki, Fukui, Toshio, Toshio Fukui   +15 more
core   +1 more source

Synaptic Ribbons Require Ribeye for Electron Density, Proper Synaptic Localization, and Recruitment of Calcium Channels

Cell Reports, 2016
Synaptic ribbons are structures made largely of the protein Ribeye that hold synaptic vesicles near release sites in non-spiking cells in some sensory systems.
Caixia Lv, William J. Stewart, Otar Akanyeti, Courtney Frederick, Jie Zhu, Joseph Santos-Sacchi, Lavinia Sheets, James C. Liao, David Zenisek   +8 more
doaj   +1 more source