Results 101 to 110 of about 74,511 (302)

Munc13-1 and Munc18-1 together prevent NSF-dependent de-priming of synaptic vesicles

Nature Communications, 2017
The molecular mechanism underlying the generation and maintenance of the readily releasable pool composed of primed synaptic vesicles is only partially known.
Enqi He, Keimpe Wierda, Rhode van Westen, Jurjen H. Broeke, Ruud F. Toonen, L. Niels Cornelisse, Matthijs Verhage   +6 more
doaj   +1 more source

Clarinet (CLA-1), a novel active zone protein required for synaptic vesicle clustering and release

eLife, 2017
Active zone proteins cluster synaptic vesicles at presynaptic terminals and coordinate their release. In forward genetic screens, we isolated a novel Caenorhabditis elegans active zone gene, clarinet (cla-1).
Zhao Xuan, Laura Manning, Jessica Nelson, Janet E Richmond, Daniel A Colón-Ramos, Kang Shen, Peri T Kurshan   +6 more
doaj   +1 more source

Microglia‐Targeted Biomimetic Tetrahedral Framework Nucleic Acid Nanovesicles for Synergistic Treatment of Sepsis‐Associated Encephalopathy

Advanced Science, EarlyView.
Sepsis‐associated encephalopathy (SAE) lacks effective therapies. We developed ME@FDsi, a biomimetic nanodrug using a tetrahedral framework nucleic acid to deliver disulfiram and siTNFα. It crosses the blood‐brain barrier, targets M1 microglia, inhibits pyroptosis and inflammation, and scavenges ROS.
Huimin Shi, Qiuxia Gao, Wenying Wang, Bin Li, Yukun Chen, Zhijun Yao, Yujie Li, Junrui Li, Na Li, Gong Gu, Zhimin Hou, Mengyuan Yang, Ruilin Zhang, Hongju Yang, Yuhui Liao, Hongyi Lei   +15 more
wiley   +1 more source

Active Zone Material-Directed Orientation, Docking, and Fusion of Dense Core Vesicles Alongside Synaptic Vesicles at Neuromuscular Junctions

Frontiers in Neuroanatomy, 2018
Active zone material is an organelle that is common to active zones along the presynaptic membrane of chemical synapses. Electron tomography on active zones at frog neuromuscular junctions has provided evidence that active zone material directs the ...
Jae H. Jung, Jae H. Jung, Joseph A. Szule, Joseph A. Szule, Kylee Stouder, Robert M. Marshall, Robert M. Marshall, Uel J. McMahan, Uel J. McMahan   +8 more
doaj   +1 more source

A targeting signal in VAMP regulating transport to synaptic vesicles

, 1995
VAMP is a synaptic vesicle membrane protein required for fusion. Synaptic vesicle targeting was measured for mutants of an epitope-tagged form of VAMP in transfected PC12 cells.
Grote, Eric, Bennett, Mark K., Hao, Joe C., Kelly, Regis B.   +3 more
core   +1 more source

A cytosolic factor mediating membrane recruitment of AP-1 clathrin adaptors [PDF]

, 2008
Transport of cargo within the endocytic and secretory pathway is generally mediated by coated vesicles. These vesicles are formed through the recruitment of cytosolic coat proteins to the donor membrane that act as a scaffold to form coated buds and ...
Suri, Gregor
core   +1 more source

Divergent Roles of mGlu2 and mGlu3 Receptors in Amyloid‐β Production and Cognitive Dysfunctions in Alzheimer's Disease

Advanced Science, EarlyView.
This study explores the opposing effects of the mGluR2 and mGluR3 receptors on amyloid precursor protein processing. mGluR2 promotes amyloidogenic cleavage, while mGluR3 favors non‐amyloidogenic pathways. Using a brain‐penetrant nanobody as a mGluR2 positive allosteric modulator, the study uncovers how its chronic activation aggravates amyloid‐β burden
Pierre‐André Lafon, Mireille Elodie Tsitokana, Ugo Guy Alenda, Yen‐Ling Lian, Clémentine Eva Philibert, Mathieu Oosterlaken, Marta Cimadevila, Gaëlle Dudon, Jessica Monnic, Salomé Roux, Julie Bessié, Séverine Diem, Franck Vandermoere, Laurent Prézeau, Patrick Chames, Julie Kniazeff, Sylvie Claeysen, Anaïs Menny, Jean‐Philippe Pin, Véronique Perrier, Jianfeng Liu, Philippe Rondard   +21 more
wiley   +1 more source

Enhanced Synaptic Transmission at the Squid Giant Synapse by Artificial Seawater Based on Physically Modified Saline

Frontiers in Synaptic Neuroscience, 2014
Superfusion of the squid giant synapse with artificial seawater (ASW) based on isotonic saline containing oxygen nanobubbles (RNS60 ASW) generates an enhancement of synaptic transmission.
Soonwook eChoi, Soonwook eChoi, Eunah eYu, Eunah eYu, Guilherme eRabello, Guilherme eRabello, Suelen eMerlo, Ajmal eZemmar, Kerry D Walton, Kerry D Walton, Herman eMoreno, Herman eMoreno, Jorge E Moreira, Jorge E Moreira, Mutsuyuki eSugimori, Mutsuyuki eSugimori, Rodolfo R Llinas, Rodolfo R Llinas   +17 more
doaj   +1 more source

Trans-synaptic assemblies link synaptic vesicles and neuroreceptors

, 2021
Synaptic transmission is characterized by fast, tightly coupled processes and complex signaling pathways that require a precise protein organization, such as the previously reported nanodomain colocalization of pre- and postsynaptic proteins.
Baumeister, Wolfgang, Martínez Sánchez, Antonio, Zinzula, L., Baumeister, W., Kochovski, Z., Papantoniou, C., Lučić, Vladan, Lucic, V., Papantoniou, Christos, Martinez-Sanchez, Antonio, Kochovski, Zdravko, Laugks, U., Zinzula, Luca, Martinez Sanchez, A., Laugks, Ulrike   +14 more
core   +1 more source

Spontaneous Non‐Catalyzed Molecular Reactions and Interactions in the Human Body: Biomedical Implications

Advanced Science, EarlyView.
ABSTRACT The human body functions as a natural reactor for a vast network of chemical and biological reactions and physical interactions among small molecules, proteins, cells, and numerous other components. These reactions/interactions are essential for maintaining normal physiological functions.
Yuhao Cai, Chao Zhao
wiley   +1 more source