Results 91 to 100 of about 74,688 (303)

Regulation of synaptic vesicle docking by different classes of macromolecules in active zone material. [PDF]

PLoS ONE, 2012
The docking of synaptic vesicles at active zones on the presynaptic plasma membrane of axon terminals is essential for their fusion with the membrane and exocytosis of their neurotransmitter to mediate synaptic impulse transmission.
Joseph A Szule, Mark L Harlow, Jae Hoon Jung, Francisco F De-Miguel, Robert M Marshall, Uel J McMahan   +5 more
doaj   +1 more source

Cholesterol and synaptic vesicle exocytosis [PDF]

Communicative & Integrative Biology, 2010
LIPIDS MAY AFFECT SYNAPTIC FUNCTION IN AT LEAST TWO WAYS: by acting as ligands for effector proteins [e.g., phosphatidylinositol (4,5) bisphosphate, diacylglycerol-mediated signaling] or by modifying the physicochemical properties and molecular organization of synaptic membranes.
Rosa P, Fratangeli A
openaire   +3 more sources

Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing

Advanced Science, EarlyView.
Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale, Marie Celine Lefevre, Alessio Carmignani, Maria Cristina Ceccarelli, Matteo Battaglini, Attilio Marino, Gianni Ciofani   +6 more
wiley   +1 more source

“Membrane‐Guided” Repair Strategy: Precision Delivery of GGT1 Degrader for Targeted Repair and Regeneration of Spinal Cord Neurons

Advanced Science, EarlyView.
This study confirms that GGT1 is a key driver of neuronal ferroptosis following spinal cord injury. We developed NSCm@EA, a biomimetic delivery system coated with neural stem cell membranes, for precise delivery of enocyanin to injured neurons. By combining targeted delivery with ubiquitination degradation mechanisms, this system promotes MGRN1 ...
Tao Yang, Lei Ye, Peigen Xie, Tao Song, Jian Chen, Heng Zhao, Zhengshan Liu, Xi Chen, Jianing Ding, Xintian Ding, Ao Shao, Miaomiao Wu, Fengdong Zhao, Siyue Tao, Tao You   +14 more
wiley   +1 more source

Real-time three-dimensional tracking of single synaptic vesicles reveals that synaptic vesicles undergoing kiss-and-run fusion remain close to their original fusion site before reuse [PDF]

, 2019
The release of neurotransmitters via the fusion between synaptic vesicles and the presynaptic membrane is an essential step in synaptic transmission. Synaptic vesicles generally undergo two distinct modes of exocytosis called full-collapse fusion and ...
Qin, Xianan, Tsien, Richard W., Park, Hyokeun   +2 more
core   +1 more source

The mobility of synaptic vesicles [PDF]

, 2009
The synaptic vesicles are small organelles containing the neurotransmitters used to communicate between neurons, and between neurons and other cells.
Kamin, Dirk, Rizzoli, S. O.
core   +2 more sources

Expanded Hepatic Progenitor Cells Featured with Aggregation of α‐Synuclein Contribute to Pathologic Bile Duct Regeneration in Biliary Atresia

Advanced Science, EarlyView.
Expanded NCAM1+EpCAM+ hepatic progenitor cells in biliary atresia are characterized by aggregation of α‐synuclein. This pathological protein potentiates cellular susceptibility to GSH‐dependent redox dyshomeostasis, induces unstable biliary cell fate specification, and subsequently drives aberrant biliary regeneration.
Hua Xie, Mengyan Zhu, Zhongxian Zhu, Jiaqi Tang, Ruyi Zhang, Zequan Ding, Junzhi Li, Zhongluan Wu, Paul Kwong Hang Tam, Qianghu Wang, Vincent Chi Hang Lui, Yankai Xia, Weibing Tang   +12 more
wiley   +1 more source

ZNF33B Promotes Japanese Encephalitis Virus Infection by Regulating the Stability of M6A‐Modified Trim25 to Control the Autophagy Process

Advanced Science, EarlyView.
Upon JEV infection, ZNF33B recruits METTL14 to stabilize the METTL3‐METTL14 m6A methyltransferase complex, leading to increased m6A modification of host transcripts, including Trim25 mRNA. ZNF33B selectively binds m6A‐modified sites on Trim25 mRNA and accelerates its decay, resulting in reduced TRIM25 protein abundance.
Jian Du, Chunwei Li, Jiyuan Luo, Huizhi Zhang, Jinyan Zhang, Suya Wang, Huanchun Chen, Hongli Xu, Xiangmin Li, Ping Qian   +9 more
wiley   +1 more source

Coreceptor and Cytokine Concentrations May Not Explain Differences in Disease Progression Observed in HIV-1 Clade A and D Infected Ugandans [PDF]

, 2011
Background: The use of cellular coreceptors and modulation of cytokine concentrations by HIV to establish a productive infection is well documented. However, it is unknown whether the expression of these proteins affects the course of HIV clade A and D ...
Zampighi Lorenzo M., Schietroma, Cataldo, Wright Edward, Ernest M. Wright, Parkes-Ratanshi, Rosalind, Grosskurth, H., Woodruff Michael, Kaleebu, Pontiano, Cataldo Schietroma, Grant, P, Ernest M, Wright, E, Parkes-Ratanshi, R., Brecha Nicholas C., Van der Paal, L., Woodruff, Michael, Lieve Van der Paal, Kaleebu, P, Brecha, Nicholas C, Zampighi Guido A., Parkes-Ratanshi, R, Wright, Edward, Guido A Zampighi, Ernest M Wright, Susan Mugaba, Grosskurth Heiner, Van der Paal, Lieve, Parkes-Ratanshi Rosalind, Grosskurth, Heiner, Mugaba, Susan, Guido A. Zampighi, Kaleebu Pontiano, Mugaba, S., Wright, Ernest M, van der Paal, L, Van der Paal Lieve, Lorenzo M Zampighi, Edward Wright, Wright Ernest M., Mugaba Susan, Paul Grant, Pontiano Kaleebu, Lorenzo M. Zampighi, Kaleebu, P., Michael Woodruff, Mugaba, S, Zampighi, Lorenzo M, Grant, P., Heiner Grosskurth, Schietroma Cataldo, Rosalind Parkes-Ratanshi, Grosskurth, H, Nicholas C. Brecha, Wright, E., Grant, Paul, Zampighi, Guido A, Grant Paul, Nicholas C Brecha   +57 more
core   +1 more source

Synaptic vesicle proteins and active zone plasticity

Frontiers in Synaptic Neuroscience, 2016
Neurotransmitter is released from synaptic vesicles at the highly specialized presynaptic active zone. The complex molecular architecture of active zones mediates the speed, precision and plasticity of synaptic transmission.
Robert J Kittel, Manfred eHeckmann
doaj   +1 more source