Results 111 to 120 of about 354,036 (296)

Regulation of synaptic connectivity: levels of fasciclin II influence synaptic growth in the Drosophila CNS [PDF]

, 2002
Much of our understanding of synaptogenesis comes from studies that deal with the development of the neuromuscular junction (NMJ). Although well studied, it is not clear how far the NMJ represents an adequate model for the formation of synapses within ...
Baines, Richard A.; id_orcid, Baines, Richard A., Salvaterra, Paul M., Thompson, Annemarie, Bate, Michael, Seugnet, Laurent   +5 more
core  

Association of N-ethylmaleimide-sensitive factor with synaptic vesicles [PDF]

, 1994
N-Ethylmaleimide-sensitive factor (NSF) mediates docking and/or fusion of transport vesicles in the multi-pathways of vesicular transport. NSF was highly expressed in brain and adrenal gland.
Rong-Mao Hong, Akitsugu Yamamoto, Futai, Masamitsu, Yutaka Tashiro, Yamamoto, Akitsugu, Masamitsu Futai, Tashiro, Yutaka, Mitsuo Tagaya, Yoshinori Moriyama, Moriyama, Yoshinori, Hiroyuki Mori, Tagaya, Mitsuo, Hong, Rong-Mao, Mori, Hiroyuki, Fukui, Toshio, Toshio Fukui   +15 more
core   +1 more source

Targeting the KCNC3‐Dependent Anterior Insular‐Lateral Orbitofrontal Cortex Glutamatergic Circuit Attenuates Post‐Traumatic Anxiety

Advanced Science, EarlyView.
Frontal lobe traumatic brain injury is associated with hyperactivity of an insular–orbitofrontal circuit in both patients and mice. By combination of integrating functional imaging, cell‐type–specific circuit manipulation, single‐cell transcriptomics, and whole‐cell recordings, this work identifies the downregulation of the potassium channel KCNC3 in ...
Meng‐Ge Li, Xiao‐Bo Qian, Hai‐Long Zhang, Di Li, Ling Ji, Xin‐Chun Xu, Jia‐Sheng Ding, Li‐Jun Yin, Li Zhang, Guang‐Yin Xu, Rong Gao   +10 more
wiley   +1 more source

Enhanced Synaptic Transmission at the Squid Giant Synapse by Artificial Seawater Based on Physically Modified Saline

Frontiers in Synaptic Neuroscience, 2014
Superfusion of the squid giant synapse with artificial seawater (ASW) based on isotonic saline containing oxygen nanobubbles (RNS60 ASW) generates an enhancement of synaptic transmission.
Soonwook eChoi, Soonwook eChoi, Eunah eYu, Eunah eYu, Guilherme eRabello, Guilherme eRabello, Suelen eMerlo, Ajmal eZemmar, Kerry D Walton, Kerry D Walton, Herman eMoreno, Herman eMoreno, Jorge E Moreira, Jorge E Moreira, Mutsuyuki eSugimori, Mutsuyuki eSugimori, Rodolfo R Llinas, Rodolfo R Llinas   +17 more
doaj   +1 more source

Coreceptor and Cytokine Concentrations May Not Explain Differences in Disease Progression Observed in HIV-1 Clade A and D Infected Ugandans [PDF]

, 2011
Background: The use of cellular coreceptors and modulation of cytokine concentrations by HIV to establish a productive infection is well documented. However, it is unknown whether the expression of these proteins affects the course of HIV clade A and D ...
Zampighi Lorenzo M., Schietroma, Cataldo, Wright Edward, Ernest M. Wright, Parkes-Ratanshi, Rosalind, Grosskurth, H., Woodruff Michael, Kaleebu, Pontiano, Cataldo Schietroma, Grant, P, Ernest M, Wright, E, Parkes-Ratanshi, R., Brecha Nicholas C., Van der Paal, L., Woodruff, Michael, Lieve Van der Paal, Kaleebu, P, Brecha, Nicholas C, Zampighi Guido A., Parkes-Ratanshi, R, Wright, Edward, Guido A Zampighi, Ernest M Wright, Susan Mugaba, Grosskurth Heiner, Van der Paal, Lieve, Parkes-Ratanshi Rosalind, Grosskurth, Heiner, Mugaba, Susan, Guido A. Zampighi, Kaleebu Pontiano, Mugaba, S., Wright, Ernest M, van der Paal, L, Van der Paal Lieve, Lorenzo M Zampighi, Edward Wright, Wright Ernest M., Mugaba Susan, Paul Grant, Pontiano Kaleebu, Lorenzo M. Zampighi, Kaleebu, P., Michael Woodruff, Mugaba, S, Zampighi, Lorenzo M, Grant, P., Heiner Grosskurth, Schietroma Cataldo, Rosalind Parkes-Ratanshi, Grosskurth, H, Nicholas C. Brecha, Wright, E., Grant, Paul, Zampighi, Guido A, Grant Paul, Nicholas C Brecha   +57 more
core   +3 more sources

Dysregulation of the MACF1‐Rab14/KIF16B‐FGFR Vesicular Trafficking Axis Skews MSC Lineage Commitment in Glucocorticoid‐Induced Osteoporosis

Advanced Science, EarlyView.
Under normal conditions, MACF1 interacts with Rab14 and facilitates KIF16B‐mediated FGFR vesicle trafficking along microtubules to the plasma membrane, thereby supporting BMSC differentiation. In contrast, chronic GC exposure suppresses MACF1 expression, disrupting this transport and causing intracellular FGFR retention, which blunts osteogenic ...
Peihong Su, Ye Tian, Fan Zhao, Jing Li, Suryaji Patil, Chunyu Zhu, Yujia Tian, Junrong Wang, Jiating Liu, Aoqi Xiang, Hua Guan, Lusha Zhang, Xiaochang Chen, Airong Qian, Qi Yu   +14 more
wiley   +1 more source

Presynaptic molecular determinants of quantal size

Frontiers in Synaptic Neuroscience, 2016
The quantal hypothesis for the release of neurotransmitters at the chemical synapse has gained wide acceptance since it was first worked out at the motor endplate in frog skeletal muscle in the 1950s.
Shigeo eTakamori
doaj   +1 more source

Neuromorphic Devices and Computing for Sensing, Memory, and Control

Advanced Science, EarlyView.
This review introduces neuromorphic devices made from diverse materials. These devices mimic neuronal functions and architectures and, when integrated with artificial or biological computing, can form closed loops with neurons for pressure, optical, acoustic, and biochemical sensing and modulation.
Zhengguang Zhu, Nicholas Schaffer, Xiao Yang   +2 more
wiley   +1 more source

A Multidimensional Engineering Strategy Reprograms Microglia via Targeted and Sustained‐Release Extracellular Vesicles for Spinal Cord Injury Repair

Advanced Science, EarlyView.
A multifunctional EV‐based nanoplatform (Ang‐TEVs@Gel) was engineered via preconditioning, surface targeting, and ROS‐responsive hydrogel encapsulation to reprogram microglia. This system restored autophagy via miR‐664a‐3p/PIK3CA axis, cleared myelin debris, resolved neuroinflammation, and promoted axon remyelination, ultimately achieving robust motor ...
Wu Xiong, Minhao Liu, Mingming Zheng, Jizhou Jia, Ziyan Zhu, Guang Kong, Jie Liu, Juan Wang, Wenbo Li, Qingyuan Wang, Qian Zhu, Peiran Chan, Tao Qin, Jiayang Wu, Yongjie Zhang, Chunming Tang, Cong Li, Jin Fan   +17 more
wiley   +1 more source

The mobility of synaptic vesicles

, 2009
The synaptic vesicles are small organelles containing the neurotransmitters used to communicate between neurons, and between neurons and other cells.
Kamin, Dirk, Rizzoli, S. O.
core   +2 more sources