Results 81 to 90 of about 2,693 (166)

Clinical imipenem non-susceptible Klebsiella pneumoniae isolates from China: Epidemiology, molecular characterization and in vitro activity of imipenem/relebactam

Journal of Global Antimicrobial Resistance
Objective: To describe the epidemiological and molecular characterization and in vitro activity of imipenem/relebactam against imipenem non-susceptible (IPMNS) Klebsiella pneumoniae isolates in China. Methods: K.
Peiyao Jia, Pengcheng Li, Wei Yu, Xiaobing Chu, Hui Zhang, Jingjia Zhang, Wei Kang, Ge Zhang, Qian Zhang, Shiyu Chen, Yingchun Xu, Qiwen Yang   +11 more
doaj   +1 more source

Combating Metallo-β-Lactamase-Producing Pseudomonas aeruginosa: The Fractional Inhibitory Concentration Index as a Tool to Evaluate Antibiotic Synergy

Antibiotics
Background: Multi-drug-resistant Gram-negative bacteria producing metallo-β-lactamase are an increasing concern. Here, we described three cases of infection due to difficult-to-treat and drug-resistant P.
Guido Granata, Carolina Venditti, Claudia Rotondo, Valentina Dimartino, Silvia D’Arezzo, Assunta Gallo, Gabriella Parisi, Alessandro Capone, Carla Fontana, Stefania Cicalini   +9 more
doaj   +1 more source

Susceptibility evaluation of novel beta-lactam/beta-lactamase inhibitor combinations against carbapenem-resistant Klebsiella pneumoniae from bloodstream infections in hospitalized patients in Brazil

Journal of Global Antimicrobial Resistance
Introduction: Novel beta-lactam/beta-lactamase inhibitor (BIBLI) combinations are commercially available and have been used for treating carbapenem-resistant Klebsiella pneumoniae (CRKP) infections.
Camila Mörschbächer Wilhelm, Laura Czerkster Antochevis, Cibele Massotti Magagnin, Beatriz Arns, Tarsila Vieceli, Dariane Castro Pereira, Larissa Lutz, Ândrea Celestino de Souza, Jéssica Nesello dos Santos, Rafaela Ramalho Guerra, Gregory S. Medeiros, Lucas Santoro, Diego R. Falci, Maria Helena Rigatto, Afonso Luís Barth, Andreza Francisco Martins, Alexandre Prehn Zavascki   +16 more
doaj   +1 more source

Antimicrobial activity of cephamycins and β-lactam/β-lactamase inhibitors against ESBL-producing Escherichia coli and Klebsiella pneumoniae under standard and high bacterial inocula

Scientific Reports
This study investigated the in vitro antimicrobial activity of cephamycins and novel β-lactam/β-lactamase inhibitor combinations, against extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli and Klebsiella pneumoniae isolates.
Yu Mi Wi, Ji Young Choi, Da Eun Lee, So Hyun Jun, Ki Tae Kwon, Kwan Soo Ko   +5 more
doaj   +1 more source

Genomic and molecular characterisation of a KPC-producing Klebsiella pneumoniae clinical isolate resistant to meropenem-vaborbactam, imipenem-relebactam, and ceftazidime-avibactam. [PDF]

BMC Genom Data
Wan Y, Wong JLC, Sanchez-Garrido J, Low WW, Turton JF, Morecchiato F, Baccani I, Dodgson K, Rossolini GM, Woodford N, Frankel G, Jauneikaite E, Meunier D, Hopkins KL.   +13 more
europepmc   +2 more sources

Successful Treatment with Imipenem/Cilastatin/ Relebactam of a Polymicrobial Bacteremia due to Meropenem/Vaborbactam-Resistant KPC-Kp and Enterococcus Faecalis. [PDF]

Mediterr J Hematol Infect Dis
Marzi F, Alessandri M, De Crescenzo V, Del Vecchio S, Radi S, Manini M.   +5 more
europepmc   +1 more source

Rapid prediction of carbapenemases in by imipenem/relebactam and MALDI-TOF MS

Pseudomonas aeruginosa is a major nosocomial pathogen commonly involved in multidrug-resistant (MDR) infections that are very difficult to treat. Imipenem/relebactam is a new carbapenem/β-lactamase inhibitor combination with robust activity against P. aeruginosa.
Candela, Ana, Fernández-Billón, María, Aja-Macaya, Pablo, González-Pinto, Lucía, Fraile-Ribot, Pablo, Viedma, Esther, Alonso-García, Isaac, Blanco-Martín, Tania, Estévez-Alfaya, Roberto, Fernández-González, Ana, Beceiro, Alejandro, López-Causapé, Carla, Oviaño, Marina, Bou, Germán, Oliver, Antonio, Arca-Suárez, Jorge   +15 more
openaire   +1 more source

<i>In vitro</i> activity of imipenem-relebactam against carbapenem-resistant <i>Pseudomonas aeruginosa</i>: correlation with carbapenem MICs and association with <i>β</i>-lactamase classes. [PDF]

Front Microbiol
Alsharidi AI, Alhumaidi RA, Albarrag AM, Al-Tawfiq JA, Somily AM.   +4 more
europepmc   +1 more source

Data-driven design and screening of novel <i>Klebsiella pneumoniae</i> carbapenemase-2 β-lactamase inhibitors using a generative CLM. [PDF]

RSC Adv
Tariq SS, Haleem MS, Uddin R.
europepmc   +1 more source

<i>In vitro</i> activity of aztreonam-nacubactam and cefepime-nacubactam against a global collection of clinically important Gram-negative Bacilli collected in 2021-2023. [PDF]

JAC Antimicrob Resist
Karlowsky JA, Estabrook M, Suzuki E, Shimizu A, Okade H.   +4 more
europepmc   +1 more source