Results 71 to 80 of about 3,353 (184)

Carbapenem Resistance in India: A Systematic Review of Epidemiology, Diagnostic Strategies, and Therapeutic Approaches

BioMed Research International, Volume 2026, Issue 1, 2026.
Background Carbapenem‐resistant gram‐negative infections pose a major public health challenge in India due to high antibiotic consumption, limited diagnostic access, and regional variation in resistance mechanisms. We systematically reviewed recent data to evaluate prevalence, diagnostics, and therapeutic strategies.
Akhil Kapoor, Anuj Gupta, Bipinesh Sansar, Bal Krishna Mishra, Madhu Singh, Rahul Sarode, Vijeta Bajpai, Anil Singh, Sujit Bharti, Anwita Mishra, Ankita Chaurasia, Satyajit Pradhan, Baisakhi Banerjee   +12 more
wiley   +1 more source

Relapsing Salmonella Meningitis in an Infant: A Case Report and Review of the Literature

Case Reports in Pediatrics, Volume 2026, Issue 1, 2026.
Accurate diagnosis of bacterial meningitis is critical, particularly in young febrile infants. Although commercially available multiplex PCR assays enable rapid pathogen detection, these typically do not include Salmonella spp. or other Enterobacteriaceae, which may result in missed diagnoses and/or inappropriate treatment duration.
Sonia Alexiadou, Elpis Mantadakis, Ioanna Irakleidou, Stavroula Kalatzi, Eleni Myrtzaki, Evlampia A. Psatha, Dimitrios Cassimos, Baisakhi Banerjee   +7 more
wiley   +1 more source

Rapid detection of KPC-producing Enterobacterales by using a modified Carba NP test with imipenem/relebactam.

, 2021
20.500.12530/87858Here, we propose a novel modified Carba NP test for detecting KPC-producing Enterobacterales using imipenem/relebactam. The test performance was evaluated in a random selection of 160 previously molecularly characterized clinical ...
González-Bardanca, Mónica, Candela, Ana, Ramírez, Cecilia de la Luna, Oviaño, Marina, Bou, Germán   +4 more
core   +1 more source

Investigating the Effect of Xylitol on ompK36 Overexpression, Increased Meropenem Susceptibility, and Antibiofilm Activity in a Carbapenem‐Resistant Clinical Strain of Klebsiella pneumoniae

International Journal of Microbiology, Volume 2026, Issue 1, 2026.
Carbapenem‐resistant Klebsiella pneumoniae poses a significant public health threat due to limited therapeutic options. This study investigated the potential of xylitol, a sugar alcohol, to enhance meropenem activity and combat biofilms in a clinical carbapenem‐resistant K. pneumoniae strain (Kp5) and a standard susceptible strain (K. pneumoniae subsp.
Omid Ahlelyorof, John Flanagan, Fereshteh Jabalameli, Reza Beigverdi, Maryam Siroosi, Divakar Sharma   +5 more
wiley   +1 more source

Development of a Practical Manufacturing Process to Relebactam via Thorough Understanding of the Origin and Control of Oligomeric Impurities

, 2021
The development of a robust manufacturing process to relebactam, a potent β-lactamase inhibitor, is described. The origin and control strategy of oligomer impurities formed during hydrogenolysis of benzyl urea intermediate 9 and deprotection of Boc ...
Marco Euclide Armenante (11525068), Zhijian Liu, Adam J. Fine (11262072), Jennifer V. Obligacion, Anil R. Ekkati, Patrick S. Fier, Zachary E. X. Dance, Jacob H. Waldman, Andrew P. J. Brunskill, Andrew P. J. Brunskill (8727768), Feiyue Wu, Jacob H. Waldman (1843948), Debra J. Wallace (1789080), Zhijian Liu (41544), Anna V. Jenks, Jungchul Kim, Adam J. Fine, Benjamin D. Sherry (1633036), Tetsuji Itoh (1633045), Patrick S. Fier (1333728), Debra J. Wallace, Feng Xu (89016), Marco Euclide Armenante, Feng Xu, Benjamin D. Sherry, Feiyue Wu (2960940), Anil R. Ekkati (2316268), Jennifer V. Obligacion (1419949), Feng Peng, Roman Kats-Kagan, Anna V. Jenks (11525065), Khateeta M. Emerson, Roman Kats-Kagan (1617472), Khateeta M. Emerson (1857049), Tetsuji Itoh, Zachary E. X. Dance (9188932), Jungchul Kim (1470538), Feng Peng (400899)   +37 more
core   +1 more source

Rapid prediction of carbapenemases in Pseudomonas aeruginosa by imipenem/relebactam and MALDI-TOF MS

Journal of Clinical Microbiology
Pseudomonas aeruginosa is a major nosocomial pathogen commonly involved in multidrug-resistant (MDR) infections that are very difficult to treat. Imipenem/relebactam is a new carbapenem/β-lactamase inhibitor combination with robust activity against P ...
Ana Candela, María Fernández-Billón, Pablo Aja-Macaya, Lucía González-Pinto, Pablo Arturo Fraile-Ribot, Esther Viedma, Isaac Alonso-García, Tania Blanco-Martín, Roberto Estévez-Alfaya, Ana Fernández-González, Alejandro Beceiro, Carla López-Causapé, Marina Oviaño, Germán Bou, Antonio Oliver, Jorge Arca-Suárez   +15 more
doaj   +1 more source

A Review of β‐Lactamase Inhibitors in Clinical Use and Development: Mechanisms, Spectrum, and Therapeutic Applications

International Journal of Microbiology, Volume 2026, Issue 1, 2026.
β‐Lactam antibiotics have long served as a cornerstone for treating bacterial infections. However, their widespread and often indiscriminate use has fueled the emergence of multidrug‐resistant Gram‐negative pathogens, primarily through the production and dissemination of β‐lactamase enzymes.
Mohammad Javad Roustaye Gourabi, Anita Nikoo, Bita Khanbabaei, Masoud Kargar, Amirhossein Fayyazi, Seyyed Mohammad Javad Mousavi, Amirhossein Aghdaee, Ali Hashemi, Javad Yasbolaghi Sharahi, Swaran J. S. Flora   +9 more
wiley   +1 more source

Aztreonam Combinations with Avibactam, Relebactam, and Vaborbactam as Treatment for New Delhi Metallo-β-Lactamase-Producing Enterobacterales Infections—In Vitro Susceptibility Testing

Pharmaceuticals
Antimicrobial resistance is a major global health issue. Metallo-β-lactamases (MBL), in particular, are problematic because they can inactivate all classes of β-lactams except aztreonam.
Małgorzata Brauncajs, Filip Bielec, Marlena Malinowska, Dorota Pastuszak-Lewandoska   +3 more
doaj   +1 more source

Abstract Supplement

Pulmonary Medicine, Volume 2026, Issue 1, 2026.
 
Marzia Folegani, Semonti Nandi
wiley   +1 more source

Rectal Carriage of Sequence Type 307 Klebsiella pneumoniae High‐Risk Clone Harboring Multiple Carbapenemase Genes in Community Hospitals Gauteng, South Africa

MicrobiologyOpen, Volume 14, Issue 6, December 2025.
Graphical presentation of rectal carriage of carbapenem‐resistant Klebsiella pneumoniae, highlighting ST307 high‐risk clone and IncX3 plasmid‐associated blaOXA‐181. This study highlights the threat linked to horizontal gene transfer of AMR genes by epidemic plasmids from Klebsiella pneumoniae high‐risk clones to other bacterial species.
Kafilat Taiwo Salvador‐Oke, Johann Pitout, Gisele Peirano, Kathy‐Anne Strydom, Chanel Kingsburgh, Marthie Ehlers, Marleen Kock   +6 more
wiley   +1 more source