Results 71 to 80 of about 2,693 (166)

Susceptibility to Imipenem/Relebactam of Pseudomonas aeruginosa and Acinetobacter baumannii Isolates from Chinese Intra-Abdominal, Respiratory and Urinary Tract Infections: SMART 2015 to 2018

Infection and Drug Resistance, 2021
Hui Zhang,1,* Peiyao Jia,1,2,* Ying Zhu,1,2,* Ge Zhang,1 Jingjia Zhang,1 Wei Kang,1 Simeng Duan,1 Weijuan Zhang,3 Qiwen Yang,1 Yingchun Xu1 1Department of Clinical Laboratory, State Key Laboratory of Complex Severe and Rare Diseases, Peking ...
Zhang H, Jia P, Zhu Y, Zhang G, Zhang J, Kang W, Duan S, Zhang W, Yang Q, Xu Y   +9 more
doaj  

AmpC induction by imipenem in Pseudomonas aeruginosa occurs in the absence of OprD and impacts imipenem/relebactam susceptibility

Microbiology Spectrum
In the United States, carbapenem resistance in Pseudomonas aeruginosa is linked to the regulation of chromosomal resistance determinants, AmpC and OprD.
Shawn Freed, Jr, Nancy D. Hanson
doaj   +1 more source

The Rapid CarbaLux Combination Test to Uncover Bacterial Resistance and Heteroresistance Prior to Antibiotic Treatment

Diagnostics
Background/Objectives: In this proof-of-concept study, the objective was to evaluate the phenotypic CarbaLux combination rapid test in terms of guiding the therapy of infections caused by multidrug-resistant Gram-negative bacteria with carbapenemase ...
Hans Rudolf Pfaendler, Hans-Ulrich Schmidt   +1 more
doaj   +1 more source

Spotlight commentary: Treatment of multidrug‐resistant Gram‐negative infections in the era of growing antimicrobial resistance

British Journal of Clinical Pharmacology, Volume 91, Issue 9, Page 2485-2489, September 2025.
Luka Bielen, Andro Vujević, Luka Csenar
wiley   +1 more source

Activity of imipenem/relebactam on Klebsiella pneumoniae with different mechanisms of imipenem non-susceptibility

Iranian Journal of Microbiology, 2021
Background and Objectives: Imipenem/relebactam (IMP/R) is a newly FDA approved β-lactam/β-lactamase inhibitor combination. Relebactam ability to restore IMP activity could differ according to the cause of imipenem non-susceptibility.
Mervat El-Sayed Mashaly, Ghada El-Saeed Mashaly   +1 more
doaj  

Activity of imipenem/relebactam against carbapenemase-producing Enterobacteriaceae with high colistin resistance

Journal of Antimicrobial Chemotherapy, 2019
Abstract Objectives Imipenem/relebactam, an investigational β-lactam/β-lactamase inhibitor combination for treatment of Gram-negative infections, and comparators including ceftazidime/avibactam, piperacillin/tazobactam and colistin were tested for activity against representative carbapenemase ...
Jessica Carpenter, Nick Neidig, Alex Campbell, Tanner Thornsberry, Taylor Truex, Tiffany Fortney, Yunliang Zhang, Karen Bush   +7 more
openaire   +2 more sources

New Antibiotics for the Treatment of Nosocomial Central Nervous System Infections

Antibiotics
Nosocomial central nervous system (CNS) infections with carbapenem- and colistin-resistant Gram-negative and vancomycin-resistant Gram-positive bacteria are an increasing therapeutic challenge. Here, we review pharmacokinetic and pharmacodynamic data and
Roland Nau, Jana Seele, Helmut Eiffert
doaj   +1 more source

Adverse Event Signals Associated with Beta-Lactamase Inhibitors: Disproportionality Analysis of USFDA Adverse Event Reporting System

Journal of Xenobiotics
Background: Beta-lactamase inhibitors (BLIs) are widely used with beta-lactam antibiotics to combat resistant infections, yet their safety profiles, especially for newer agents, remain underexplored.
Kannan Sridharan, Gowri Sivaramakrishnan
doaj   +1 more source

In Vitro Efficacy of Imipenem/Relebactam Against Imipenem Resistant Gram-Negative Strains Isolated from a Tertiary Care Hospital

Pakistan Armed Forces Medical Journal
Objective: To determine in vitro efficacy of Imipenem/Relebactam against multi-drug resistant strains. Study Design: Cross-sectional study. Place and Duration of Study: Department of Microbiology, Fauji Foundation Hospital (FFH) Rawalpindi, Pakistan
Saima Ishtiaq, Sonia Tahir, Muhammad Waqas Abbas, Haider Ali, Saima Syed, Fatima Kareem   +5 more
doaj   +1 more source

Combinación de antibióticos carbapenémicos con relebactam sobre enterobacterias productoras de carbapenemasas

Correo Científico Médico
Las enterobacterias productoras de carbapenemasas se han diseminado por todo el mundo y causan infecciones de alta mortalidad y morbilidad. Los antibióticos carbapenémicos se utilizan como último recurso frente a las infecciones graves producidas por ...
Washington Paúl Culqui Molina, Martha Elizabeth Loor Flores, Mónica Viviana Moscoso Silva   +2 more
doaj