Results 51 to 60 of about 2,720 (166)
Journal of Antimicrobial Chemotherapy, 2021 Abstract Background Imipenem/relebactam is a novel carbapenem/β-lactamase inhibitor combination, developed to act against carbapenemase-producing Enterobacterales (CPE). Objectives To assess the in vitro activity of imipenem ...
Juan Carlos Vázquez-Ucha +40 more
openaire +5 more sources
ChemMedChem, Volume 21, Issue 9, 14 May 2026.Combining enhanced permeability strategies with (2‐pyridyl)methylene substitution in the sulbactam scaffold led to a novel β‐lactamase inhibitor to combat β‐lactamase‐mediated resistance to β‐lactam antibiotics. The studies presented highlight the potential of compound 3 as a next‐generation β‐lactamase inhibitor for combating infections caused by ...
Diana Rodríguez +4 more
wiley +1 more source
Journal of Clinical Laboratory Analysis, Volume 40, Issue 10, May 2026.The primary mechanism of carbapenem resistance identified in pediatric CRKP‐BSI strains was the production of Class B metalloenzymes. We report, for the first time, an outbreak of bloodstream infections in a neonatal ward caused by the dissemination of NDM‐1‐producing ST25 K. pneumoniae.
Mingming Zhou +8 more
wiley +1 more source
Clinical Pharmacology &Therapeutics, Volume 119, Issue 3, Page 608-617, March 2026.This manuscript describes the scope of implementation and impact of a regulatory agency‐qualified panel of six urine biomarkers on drug development, the process for which was conducted and funded by the Critical Path Institute, the Foundation for the National Institutes of Health, and the United States Food and Drug Administration.
Tanja S. Zabka +7 more
wiley +1 more source
An efficient and practical approach to synthesis of relebactam
Synthetic CommunicationsA novel and practical seven-step synthesis of relebactam has been developed, starting from (2 R,5S)-5-((benzyloxy)amino)piperidine-2-carboxylic acid, achieving an overall yield of 42.27% with high HPLC purity (99.27%). This approach offers an efficient synthesis of the key diazabicyclooctane (DBO) core, while also demonstrating cost-effectiveness and ...
Qiu, Baojie +4 more
openaire +1 more source
Reversing Antibiotic Resistance: Strategies From Adjuvants to Innovative Therapeutics
MicrobiologyOpen, Volume 15, Issue 1, February 2026.Molecular reversal strategies against antibiotic resistance act through three mechanisms: inhibiting resistance gene function, blocking horizontal gene transfer, and modulating host defense. Emerging technologies, such as CRISPR‐Cas gene editing, photodynamic therapy, nanotechnology, and ecological competition, further strengthen these approaches ...
Tianjiao Li +4 more
wiley +1 more source
International Journal of Microbiology, Volume 2026, Issue 1, 2026.Carbapenem‐resistant Klebsiella pneumoniae poses a significant public health threat due to limited therapeutic options. This study investigated the potential of xylitol, a sugar alcohol, to enhance meropenem activity and combat biofilms in a clinical carbapenem‐resistant K. pneumoniae strain (Kp5) and a standard susceptible strain (K. pneumoniae subsp.
Omid Ahlelyorof +5 more
wiley +1 more source
International Journal of Microbiology, Volume 2026, Issue 1, 2026.β‐Lactam antibiotics have long served as a cornerstone for treating bacterial infections. However, their widespread and often indiscriminate use has fueled the emergence of multidrug‐resistant Gram‐negative pathogens, primarily through the production and dissemination of β‐lactamase enzymes.
Mohammad Javad Roustaye Gourabi +9 more
wiley +1 more source
Rapid prediction of carbapenemases in Pseudomonas aeruginosa by imipenem/relebactam and MALDI-TOF MS
Journal of Clinical MicrobiologyPseudomonas aeruginosa is a major nosocomial pathogen commonly involved in multidrug-resistant (MDR) infections that are very difficult to treat. Imipenem/relebactam is a new carbapenem/β-lactamase inhibitor combination with robust activity against P ...
Ana Candela +15 more
doaj +1 more source