Results 141 to 150 of about 2,934,024 (293)

Behavioral differentiation during the AIGC image generation waiting period: effects on creativity in conceptual design. [PDF]

Front Psychol
Zhu Z, Xu J.
europepmc   +1 more source

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Relevance and modality

, 1998
This paper sets out to reasess some relevance-theoretic analyses of the English modals, in particular Walton (1988), Groefsema(1995), Klinge (1993) and Berbeira Gardón (1996a), and show how a unified treatment of modal verbs is possible within the ...
Berbeira Gardón, José Luis
core  

Assessing clinical relevance of off-target effects observed at suprapharmacological concentrations of SGLT2 inhibitors. [PDF]

J Clin Invest
Taylor SI.
europepmc   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

DIFFERENTIAL CHANGES IN THE VALUE-RELEVANCE OF EARNINGS AND BOOK VALUES OVER TIME: FINANCIAL VERSUS OTHER INDUSTRIES [PDF]

We investigate the change in the value-relevance of earnings and book value information in the financial industry compared to other industries from 1970 to 2005.
Sharad Asthana, Lucy Huajing Chen
core  

Profiling perceived knowledge, relevance and interest across geriatric topics of health and social care professionals: multinational electronic cross-sectional survey. [PDF]

Age Ageing
Soraci L, Ogliari G, Benetos A, Bogdanovic N, Bonin-Guillaume S, Duque S, Ekdahl AW, Harasani K, Herghelegiu AM, Jakovljević D, Kossioni A, Kotsani M, Kravvariti E, Lindner-Rabl S, Macijauskienė J, Martínez-Velilla N, Masud T, Pavic T, Petrovic M, Piotrowicz K, Romero-Ortuno R, Polidori-Nelles MC, Ruggiero C, Savas S, Soulis G, Tiwari D, Lietzen LW, Roller-Wirnsberger R, Vassallo M.   +28 more
europepmc   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Letter to the editor about the article: "Hypopressive exercises for diastasis recti and pelvic floor symptoms in postpartum women: A randomized trial". [PDF]

Braz J Phys Ther
Delgado A, Bona AF.
europepmc   +1 more source