Results 201 to 210 of about 2,830,468 (238)

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

The Medicine Quality Monitoring Globe: A public health intelligence system for collecting and curating reports of substandard and falsified medical products from publicly available Internet news media. [PDF]

PLOS Digit Health
Freifeld CC, Van Assche K, Olliaro A, Battain M, Kitignavong I, Vidhamaly V, Boupha P, Boutsamay K, Thi Do N, Bellingham K, Pimxayvong V, Olinh T, Rosado Olmo A, Xu J, Jiang S, Soult A, Insal S, Guérin PJ, Newton PN, Caillet C.   +19 more
europepmc   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

ADHD: Beyond Core Symptoms and Specialist Care. [PDF]

J Clin Med
Jaeschke RR.
europepmc   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Cross-domain transfer learning strategy enhances interpretability of deep learning model explanations. [PDF]

Sci Rep
Zannini M, Hammer A, Malberg H, Schmidt M.   +3 more
europepmc   +1 more source

Patient-centred and fit-for-purpose clinical trials in rare cancers: lessons from sarcomas for operationalising 2024 WHO Guidance and ICH E6(R3). [PDF]

EClinicalMedicine
Gonzato O, Reinke D, Wilson R, Kasper B, Ruiz Alvarez MJ.   +4 more
europepmc   +1 more source

Which quality of life issues are important to patients with metastatic breast cancer: Phase 1 and 2 development of European Organisation for Research and Treatment of Cancer metastatic breast cancer module (EORTC QLQ-MBR). [PDF]

Breast
Bedding C, Absolom K, Pogoda K, Shimomura A, Ishiki H, Arraras JI, Peron J, Pinto M, Nevries N, Shamieh O, Chalk T, Young T, Bjelic-Radisic V, Alrjoub W, Kikawa Y, Cardoso F, Velikova G, EORTC Quality of Life Group, Breast Cancer Group.   +18 more
europepmc   +1 more source

From Test Offer to Urologic Follow-up: Acceptability of Semen Analysis in Male Infertility and Preconception Care. [PDF]

Cureus
Kojo K, Nakazono A, Oguri T.
europepmc   +1 more source