Results 201 to 210 of about 2,934,024 (293)

Developing a Theory-Driven Construct of Clinical Usefulness for Evaluating Post-Hoc Explainable AI: Foundational Work for a Multi-Phase Instrument Program. [PDF]

J Eval Clin Pract
Bauer JM, Michalowski M.
europepmc   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

Risk of biliary diseases in patients with type 2 diabetes or obesity treated with tirzepatide: A critical appraisal

Journal of Diabetes Investigation
Salvatore Corrao
doaj   +1 more source

Accuracy, Relevance, and Redundancy of ChatGPT-5.3 References in Open Fracture Management: A Methodological Analysis. [PDF]

Cureus
Kutluay GE, Kondil Y.
europepmc   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Beyond the Dispensary: Pharmacists' Perspectives on the Responsible Implementation of Emerging Clinical, Digital, and Ethically Sensitive Roles. [PDF]

Pharmacy (Basel)
Mosch C, Simon C, Dusinovic E, Clemens S, Pachmayr J, Rose O.   +5 more
europepmc   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Evaluation of online cancer information for Aboriginal and Torres Strait Islander peoples: a systematic environmental scan. [PDF]

JNCI Cancer Spectr
Maxwell-Smith C, Iazzi DE, Jetta C, Garvey G, Basson M, Dhillon HM, Halkett GKB.   +6 more
europepmc   +1 more source