Results 41 to 50 of about 5,178,489 (298)

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács, Zoltán Köllő, Balázs Gellért Karvaly, Mahmoud Obeidat, Rita Nagy, Péter Hegyi, Brigitta Teutsch, Eszter Tuboly, Miklós Garami   +8 more
wiley   +1 more source

Adherence to Protocol Recommendations for Children With Wilms Tumour in Two Consecutive Studies in the United Kingdom and Ireland—Does Variation Matter?

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background and Aims Wilms tumour (WT) has excellent event‐free and overall survival (OS). However, small differences exist between countries participating in the same international study. This led us to examine variation in adherence to protocol recommendations as a potential contributing factor.
Suzanne Tugnait, R. Al‐Saadi, A. Lopez‐Cortes, K. Dzhuma, M. Oostveen, J. Brok, S. Irtan, M. Weeks, J. Bate, S. Baker, R. Williams, M. Powis, D. Saunders, O. Olsen, T. Watson, S. Shelmerdine, S. Vaidya, L. Howell, C. Duncan, G. M. Vujanic, C. Stiller, G. P. Balchin, T. Chowdhury, K. Pritchard‐Jones   +23 more
wiley   +1 more source

Incorporating user search behaviour into relevance feedback [PDF]

, 2003
In this paper we present five user experiments on incorporating behavioural information into the relevance feedback process. In particular we concentrate on ranking terms for query expansion and selecting new terms to add to the user's query.
Beaulieu, Borlund, Borlund, Borlund, Campbell, Campbell, Efthimiadis, Ellis, Florance, Haines, Harman, Harman, Kuhlthau, Kuhlthau, Over, Porter, Robertson, Robertson, Ruthven, Ruthven, Ruthven, Ruthven, Ruthven, Salton, Spink, Vakkari, Vakkari, Voorhees   +27 more
core   +2 more sources

The Evolution of Relevance [PDF]

Cognitive Science, 2010
AbstractWith human language, the same utterance can have different meanings in different contexts. Nevertheless, listeners almost invariably converge upon the correct intended meaning. The classic Gricean explanation of how this is achieved posits the existence of four maxims of conversation, which speakers are assumed to follow.
openaire   +2 more sources

Sirolimus for Extracranial Arteriovenous Malformations: A Scoping Review of the Evidence in Syndromic and Non‐Syndromic Cases

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Arteriovenous malformations (AVMs) are rare, high‐flow, vascular anomalies that can occur either sporadically or as part of a genetic syndrome. AVMs can progress with serious morbidity and even mortality if left unchecked. Sirolimus is an mTOR inhibitor that is effective in low‐flow vascular malformations; however, its role in AVMs is unclear.
Will Swansson, Ingrid Winship, Gary Hammerschlag, Laura Scardamaglia   +3 more
wiley   +1 more source

On the Relevance of the Thermal Scalar [PDF]

, 2014
We discuss near-Hagedorn string thermodynamics in general spacetimes using the formalism of the thermal scalar. Building upon earlier work by Horowitz and Polchinski, we relate several properties of the thermal scalar field theory (i.e. the stress tensor
Mertens, Thomas G., Verschelde, Henri, Zakharov, Valentin I.   +2 more
core   +3 more sources

User perspectives on relevance criteria: A comparison among relevant, partially relevant, and not‐relevant judgments [PDF]

Journal of the American Society for Information Science and Technology, 2002
AbstractThis study investigates the use of criteria to assess relevant, partially relevant, and not‐relevant documents. Study participants identified passages within 20 document representations that they used to make relevance judgments; judged each document representation as a whole to be relevant, partially relevant, or not relevant to their ...
Kelly Maglaughlin, Diane H. Sonnenwald
openaire   +2 more sources

Evaluating the Utility of Paired Tumor and Germline Targeted DNA Sequencing for Pediatric Oncology Patients: A Single Institution Report

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate the diagnostic yield and utility of universal paired tumor–normal multigene panel sequencing in newly diagnosed pediatric solid and central nervous system (CNS) tumor patients and to compare the detection of germline pathogenic/likely pathogenic variants (PV/LPVs) against established clinical referral criteria for cancer ...
Natalie Waligorski, Rebecca Ronsley, Shannon M. Stasi, Jeffrey Stevens, Erin R. Rudzinski, Christina M. Lockwood, Sarah E. S. Leary, Bonnie L. Cole, Michelle A. Ting, Vera Paulson   +9 more
wiley   +1 more source

Editorial: Relevance Theory and Intercultural Communication Problems [PDF]

, 2017
This editorial to the special issue of RiL dedicated to relevance theory and problems of intercultural communication addresses the general requirements that a theory of communication must meet to be applicable to the analysis of intercultural ...
Agnieszka Piskorska, Brown, Brown, Escandell, Escandell, Escandell, Escandell, Escandell, Escandell, Fukada, Fukada, Goffman, Goffman, Goldsmith, Goldsmith, Grice, Grice, Grice, Grice, Ide, Ide, Jary, Jary, Keenan Ochs, Keenan Ochs, Matsumoto, Matsumoto, Sperber, Sperber, Trosborg, Trosborg, Van, Van, Van, Van, Van, Van, Wilson, Wilson   +38 more
core   +2 more sources

Preferences of Pediatric Patients and Their Caregivers for Chemotherapy‐Induced Nausea and Vomiting Control Endpoints: A Mixed Methods Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Although not always achieved, complete chemotherapy‐induced nausea and vomiting (CINV) control is the conventional goal of CINV prophylaxis. In this two‐center, mixed‐methods study, we sought to understand the preferences of adolescent patients and family caregivers for CINV control endpoints.
Haley Newman, Tadi Hondonga, Alison Berry, Caitlin Elgarten, Jason Freedman, Katelyn Oranges, Sara McDonough, Caroline Diorio, L. Lee Dupuis   +8 more
wiley   +1 more source