Results 61 to 70 of about 1,549,285 (265)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

The Relevancy of the Relevance: Different Aspects of Relevancy During Emotional Episodes Evaluations

Acta Psychologica
The present research investigates the effect of relevance on our subjective experience while generating alternative events in our mind. To accomplish this aim, we asked participants to read and visualize 280 situations outlined in concise scripts. During each trial, they evaluated the relevance of the situation and other aspects of their metacognitive ...
Dalit Milshtein, Jamalat Badarneh, Avishai Henik   +2 more
openaire   +3 more sources

Correlation Between Angular Position and Pathological Changes in Impacted Lower Third Molars: A Systematic Review and Meta-Analysis

Dentistry Journal
Background: The extraction of impacted third molars presents anatomical challenges and surgical risks, prompting debate over prophylactic removal, particularly for impacted lower molars.
Shaniko Kaleci, Pierantonio Bellini, Giacomo Setti, Giulia Melloni, Matilde Ruozzi, Ugo Consolo   +5 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Zero-index metamaterial based all-dielectric nanoantenna

AIP Advances, 2019
In this article, a highly directive all-dielectric zero-index metamaterial (ZIM) based nanoantenna has been proposed which has the ability to directionally transmit the radiation from an isotropic quantum emitter.
Nishant Shankhwar, Yogita Kalra, Qiang Li, Ravindra Kumar Sinha   +3 more
doaj   +1 more source

Building Connections Through Contextualized Learning in an Undergraduate Course on Scientific and Mathematical Literacy

International Journal for the Scholarship of Teaching and Learning, 2015
With increasing demands for universities to create graduates that are numerically and scientifically literate, it is important to determine effective ways to engage students so that they can acquire these literacies.
Melanie Rathburn
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source