Results 71 to 80 of about 2,830,468 (238)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Central obesity in psoriatic arthritis: associations with disease activity, function, and quality of life in a real-world cohort

Frontiers in Medicine
ObjectiveThis study aimed to explore the association between central obesity and disease-specific activity, functional impairment, and patient-reported outcomes (PROMs) in a real-world cohort of individuals with psoriatic arthritis (PsA).MethodsWe ...
Salvatore Corrao, Salvatore Corrao, Salvatore Scibetta, Salvatore Scibetta, Luigi Calvo, Marika Lo Monaco, Raffaella Mallaci Bocchio, Giuseppe Natoli, Antonella Montalbano, Ignazio Cangemi, Christiano Argano   +10 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Tirzepatide against obesity and insulin-resistance: pathophysiological aspects and clinical evidence

Frontiers in Endocrinology
Obesity is a chronic, multifactorial disease in which accumulated excess body fat has a negative impact on health. Obesity continues to rise among the general population, resulting in an epidemic that shows no significant signs of decline. It is directly
Salvatore Corrao, Salvatore Corrao, Chiara Pollicino, Dalila Maggio, Alessandra Torres, Christiano Argano   +5 more
doaj   +1 more source

Formalizing Informal Logic

Informal Logic, 2015
This paper presents a formalization of informal logic using the Carneades Argumentation System (CAS), a formal, computational model of argument that consists of a formal model of argument graphs and audiences.
Douglas Walton, Thomas F. Gordon
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Quantitative Assessment of Apically Extruded Debris During Retreatment Procedures Using Three Nickel-Titanium Rotary Systems: An In Vitro Comparative Study

Dentistry Journal
Objectives: Apical extrusion of debris can affect the success of endodontic treatments, and the specific performance of certain retreatment systems has not been studied yet.
Luigi Generali, Federica Veneri, Francesco Cavani, Vittorio Checchi, Carlo Bertoldi, Angela Lucia Ingrosso, Giusy Rita Maria La Rosa, Eugenio Pedullà   +7 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

The "Fame Effect" or How the syntactic choices of writers can be explained by their assumptions about their addressees' state of knowledge: the case of relevance-oriented, non-restrictive noun modifiers

Discours, 2010
In this paper we would like to explore, within Vallduví’s (1992, 1993) information packaging theory, how writers’ assumptions about their addressees’ state of knowledge can account for the choice writers make between competing syntactic structures, which
Rudy Loock
doaj   +1 more source