Results 91 to 100 of about 5,178,489 (298)

Beyond inflammation: metabolic implications of biological and TsDMARD therapies in dermatologic and rheumatologic diseases

Frontiers in Immunology
Biologic and targeted synthetic disease-modifying antirheumatic drugs (DMARDs) have transformed the management of chronic inflammatory diseases. Yet their therapeutic impact extends beyond cytokine suppression, influencing systemic metabolic pathways ...
Salvatore Corrao, Salvatore Corrao, Salvatore Scibetta, Salvatore Scibetta, Nicola Pardo, Ignazio Cangemi, Luigi Mirarchi, Giacomo Corrao, Simona Amodeo, Luigi Calvo   +9 more
doaj   +1 more source

How Intraday Index Changes Influence Periodontal Assessment: A Preliminary Study

International Journal of Dentistry, 2017
It is reputed that periodontal indices remain unchanged over a 24-hour period, with great clinical significance. This preliminary study analyzes daily index changes. In 56 selected patients, full-mouth plaque score (FMPS), full-mouth bleeding score (FMBS)
Carlo Bertoldi, Andrea Forabosco, Michele Lalla, Luigi Generali, Davide Zaffe, Pierpaolo Cortellini   +5 more
doaj   +1 more source

Hopfield Networks in Relevance and Redundancy Feature Selection Applied to Classification of Biomedical High-Resolution Micro-CT Images [PDF]

, 2008
We study filter–based feature selection methods for classification of biomedical images. For feature selection, we use two filters — a relevance filter which measures usefulness of individual features for target prediction, and a redundancy filter, which
Auffarth, B., Cerquides, J., Lopez, M.
core   +1 more source

Claudin‐6 Protein Expression in Atypical Teratoid/Rhabdoid Tumors Is Strongly Enriched in the Molecular Subgroup AT/RT‐TYR

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Claudin‐6 has emerged as a promising immunotherapeutic target, yet protein‐level data in atypical teratoid/rhabdoid tumors (AT/RTs) have been inconsistent. We analyzed 36 well‐characterized AT/RT samples and found membranous claudin‐6 protein expression in 58% of cases, with striking enrichment in the molecular subgroup AT/RT‐TYR (100%) and ...
Victoria E. Fincke, Christian Thomas, Michael C. Frühwald, Pascal D. Johann, Martin Hasselblatt   +4 more
wiley   +1 more source

Central obesity in psoriatic arthritis: associations with disease activity, function, and quality of life in a real-world cohort

Frontiers in Medicine
ObjectiveThis study aimed to explore the association between central obesity and disease-specific activity, functional impairment, and patient-reported outcomes (PROMs) in a real-world cohort of individuals with psoriatic arthritis (PsA).MethodsWe ...
Salvatore Corrao, Salvatore Corrao, Salvatore Scibetta, Salvatore Scibetta, Luigi Calvo, Marika Lo Monaco, Raffaella Mallaci Bocchio, Giuseppe Natoli, Antonella Montalbano, Ignazio Cangemi, Christiano Argano   +10 more
doaj   +1 more source

Time Toxicity in Wilms Tumor: Quantifying the Burden of Healthcare Interaction in the First Year After Diagnosis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Wilms tumor (WT) treatment imposes a significant time burden on patients and their families. Time toxicity is a patient‐centered metric that quantifies the burden of healthcare interaction. We sought to define time toxicity in the first year after diagnosis of WT and hypothesized that it would increase as tumor stage and treatment ...
Caleb Q. Ashbrook, Veerain Gupta, Nicholas J. Clark, Vijay Rings, Lauren E. Corona, Douglass B. Clayton, Daniel J. Benedetti   +6 more
wiley   +1 more source

Tirzepatide against obesity and insulin-resistance: pathophysiological aspects and clinical evidence

Frontiers in Endocrinology
Obesity is a chronic, multifactorial disease in which accumulated excess body fat has a negative impact on health. Obesity continues to rise among the general population, resulting in an epidemic that shows no significant signs of decline. It is directly
Salvatore Corrao, Salvatore Corrao, Chiara Pollicino, Dalila Maggio, Alessandra Torres, Christiano Argano   +5 more
doaj   +1 more source

Relevance of Dynamic Clustering to Biological Networks

, 1993
Network of nonlinear dynamical elements often show clustering of synchronization by chaotic instability. Relevance of the clustering to ecological, immune, neural, and cellular networks is discussed, with the emphasis of partially ordered states with ...
Aertsen, Aertsen, Chaté, Connel, Eckhorn, Eigen, Elton, Farmer, Freeman, Freeman, Gray, Hakim, Holland, Ikeda, Ikegami, Ikegami, Kaneko, Kaneko, Kaneko, Kaneko, Kaneko, Kaneko, Kaneko, Kaneko, Kaneko, Kauffman, Kikkawa, Ko, Kunihiko Kaneko, May, Nakagawa, Tsuda, Tsuda, Tsuda, Tsuda   +34 more
core   +1 more source

Therapeutic Apheresis for Intravenous Methylprednisolone‐Refractory Neuromyelitis Optica Spectrum Disorder: Clinical and Radiological Outcomes in a Single‐Center Case Series

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Neuromyelitis optica spectrum disorder (NMOSD) is a relapsing autoimmune disease of the central nervous system. High‐dose intravenous methylprednisolone (IVMP) is the standard first‐line therapy for acute attacks, although some patients remain refractory.
Wataru Horiguchi, Daisuke Katagiri, Takeyuki Watadani, Shunichi Matsuda, Hiroshi Kaneko, Noritoshi Arai   +5 more
wiley   +1 more source

Formalizing Informal Logic

Informal Logic, 2015
This paper presents a formalization of informal logic using the Carneades Argumentation System (CAS), a formal, computational model of argument that consists of a formal model of argument graphs and audiences.
Douglas Walton, Thomas F. Gordon
doaj   +1 more source