Results 81 to 90 of about 2,934,024 (293)

Beyond inflammation: metabolic implications of biological and TsDMARD therapies in dermatologic and rheumatologic diseases

Frontiers in Immunology
Biologic and targeted synthetic disease-modifying antirheumatic drugs (DMARDs) have transformed the management of chronic inflammatory diseases. Yet their therapeutic impact extends beyond cytokine suppression, influencing systemic metabolic pathways ...
Salvatore Corrao, Salvatore Corrao, Salvatore Scibetta, Salvatore Scibetta, Nicola Pardo, Ignazio Cangemi, Luigi Mirarchi, Giacomo Corrao, Simona Amodeo, Luigi Calvo   +9 more
doaj   +1 more source

VASIL SUKHOMLYNSKY’S SCHOOL AS AN AUTHOR’S PEDAGOGICAL SYSTEM

Education: Modern Discourses, 2018
The article presents the essential features of V. Sukhomlynsky’s school as an autho’s pedagogical system on the basis of holistic analysis. It is proved that the pedagogical system of the outstanding teacher in its essence and character belongs to ...
Anna Trotsko, Olena Popova
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Prediction of relevance of an image from a scan pattern

, 2008
This report considers the task of inferring implicit relevance feedback from eye movements in image retrieval settings. The feasibility of solving the problem without using any image-level features is demonstrated on two different search settings, and ...
Saunders, Craig, Kaski, Samuel, de Campos, Teófilo, Klami, Arto, Pasupa, Kitsuchart   +4 more
core   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

A metaphorical characterization of D.J. Opperman's Komas uit 'n bamboesstok in terms of relevance theory and the contemporary theory of metaphor [PDF]

, 2009
Includes abstract.Includes bibliographical references (leaves 188-198).Similar to previous academic papers on the topic of relevance, this dissertation too responds to specific claims proposed by relevance theory.
Van Rooyen, Ian William
core   +1 more source

Adipose tissue dysfunction and the liver: reframing MASH as the hepatic expression of systemic metabolic dysfunction

Frontiers in Endocrinology
Metabolic dysfunction-associated steatohepatitis (MASH) is conventionally investigated and treated as a primary disease of the liver. In type 2 diabetes, however, the hepatic lesion is best understood as the visible endpoint of a systemic disorder of ...
Salvatore Corrao, Salvatore Corrao, Christiano Argano   +2 more
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Disrupting the adiposopathy-inflammation loop: a translational immunometabolic framework for inflammatory disease

Journal of Translational Medicine
Adipose tissue dysfunction is increasingly recognized as a biologically active contributor to chronic inflammatory disease beyond its traditional role in energy storage.
Salvatore Corrao
doaj   +1 more source

Central obesity in psoriatic arthritis: associations with disease activity, function, and quality of life in a real-world cohort

Frontiers in Medicine
ObjectiveThis study aimed to explore the association between central obesity and disease-specific activity, functional impairment, and patient-reported outcomes (PROMs) in a real-world cohort of individuals with psoriatic arthritis (PsA).MethodsWe ...
Salvatore Corrao, Salvatore Corrao, Salvatore Scibetta, Salvatore Scibetta, Luigi Calvo, Marika Lo Monaco, Raffaella Mallaci Bocchio, Giuseppe Natoli, Antonella Montalbano, Ignazio Cangemi, Christiano Argano   +10 more
doaj   +1 more source