Results 81 to 90 of about 1,130,991 (283)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

open access: yesMolecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir   +12 more
wiley   +1 more source

Conceptual Relevance Feedback [PDF]

open access: yes, 2002
Contains fulltext : 176140.pdf (Publisher’s version ) (Open Access)
Grootjen, F.A., Weide, T.P. van der
openaire  

Relevance feedback models for recommendation [PDF]

open access: yesProceedings of the 2006 Conference on Empirical Methods in Natural Language Processing - EMNLP '06, 2006
We extended language modeling approaches in information retrieval (IR) to combine collaborative filtering (CF) and content-based filtering (CBF). Our approach is based on the analogy between IR and CF, especially between CF and relevance feedback (RF). Both CF and RF exploit users' preference/relevance judgments to recommend items. We first introduce a
Masao Utiyama, Mikio Yamamoto
openaire   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

open access: yesMolecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak   +4 more
wiley   +1 more source

Interactive Exploration for Image Retrieval

open access: yesEURASIP Journal on Advances in Signal Processing, 2005
We present a new version of our content-based image retrieval system RETIN. It is based on adaptive quantization of the color space, together with new features aiming at representing the spatial relationship between colors.
Jérôme Fournier   +3 more
doaj   +1 more source

External query reformulation for text-based image retrieval [PDF]

open access: yes, 2011
In text-based image retrieval, the Incomplete Annotation Problem (IAP) can greatly degrade retrieval effectiveness. A standard method used to address this problem is pseudo relevance feedback (PRF) which updates user queries by adding feedback terms ...
Jones, Gareth J.F., Min, Jinming
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

open access: yesMolecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla   +10 more
wiley   +1 more source

Selected results from a large study of Web searching: the Excite study

open access: yesInformation Research: An International Electronic Journal, 2000
This paper reports selected findings from an ongoing series of studies analyzing large-scale data sets containing queries posed by Excite users, a major Internet search service.
Amanda Spink, Jack L. Xu
doaj  

Evaluating Relevance Feedback: An Image Retrieval Interface for Children [PDF]

open access: yes, 2008
Studies on information retrieval for children are not yet\ud common. As young children possess a limited vocabulary\ud and limited intellectual power, they may experience more\ud difficulty in fulfilling their information need than adults.\ud This paper ...
Bockting, S.   +4 more
core   +1 more source

Estimating Position Bias without Intrusive Interventions

open access: yes, 2018
Presentation bias is one of the key challenges when learning from implicit feedback in search engines, as it confounds the relevance signal. While it was recently shown how counterfactual learning-to-rank (LTR) approaches \cite{Joachims/etal/17a} can ...
Agarwal Aman   +6 more
core   +1 more source

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