Results 111 to 120 of about 2,027,234 (292)
Some preliminary remarks on the relevance of topological essentiality in general equilibrium theory and game theory [PDF]
We define an algebro-topological concept of essential map and we use it to prove several results in the theory of general equilibrium and nash equilibrium refinement.fixed point theory, game theory, equilibrium theory, stability of Nash equilibrium ...
Dries Vermeulen +2 more
core
Molecular Oncology, EarlyView.Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard +12 more
wiley +1 more source
Aggregation theory and the relevance of some issues to others [PDF]
I propose a general collective decision problem consisting in many issues that are interconnected in two ways: by mutual constraints and by connections of relevance.
Dietrich, Franz
core +1 more source
A computer scientist looks at game theory
, 2002 I consider issues in distributed computation that should be of relevance to game theory. In particular, I focus on (a) representing knowledge and uncertainty, (b) dealing with failures, and (c) specification of mechanisms.Comment: To appear, Games and ...
Halpern, Joseph Y.
core +4 more sources
Survivin and Aurora Kinase A control cell fate decisions during mitosis
Molecular Oncology, EarlyView.Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir +2 more
wiley +1 more source
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
RELEVANCE OF DUALITY THEORY TO THE PRACTICING AGRICULTURAL ECONOMIST: DISCUSSION [PDF]
Research Methods/ Statistical Methods,
Halter, A.N.
core +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Problem-Solving Negotiation: Northern Ireland\u27s Experience with the Women\u27s Coalition Symposium [PDF]
, 2003 This paper is part of a Symposium that considered the relevance of domestic conflict resolution theories in broader cultural contexts. The Northern Ireland Women\u27s Coalition (Women\u27s Coalition) participated in the negotiations leading up to the ...
Hinds, Bronagh, Nolan-Haley, Jacqueline
core +2 more sources