Results 101 to 110 of about 2,041,658 (288)
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Towards a pragmatics of non-fictional narrative truth: Gricean and relevance-theoretic perspectives
Stellenbosch Papers in Linguistics Plus, 2016 From a linguistic perspective, ‘truth’ is undoubtedly a pragmatic notion, as the truth of an utterance is not determined solely by its linguistic meaning, but is dependent upon the context in which it is uttered.
Berghoff, Robyn, Huddlestone, Kate
doaj +1 more source
The Relevance of Evolutionary Science For Economic Theory and Policy [PDF]
NSF’s “Dear Colleague Letter” reflects the widely perceived need to go beyond current economic theory in the formulation of public policy. At the same time, there is a profound lack of unity among the disciplines that comprise the behavioral, social, and
David Sloan Wilson, John M. Gowdy
core
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source
Argumentation and Cognition: Can Pragma-Dialectics Interplay with Pragma-Semantics?
Critical Approaches to Discourse Analysis across Disciplines, 2007 This paper addresses the possibility of a cognitive account of argumentation, by focusing on a tentative interplay between one of today’s most influential theories of argumentation – van Eemeren and Grootendorst’s Pragma-Dialectics – and Relevance Theory.
Steve Oswald
doaj
relevance theory explaining verbal communication
Stellenbosch Papers in Linguistics Plus, 2013 No ...
Sinclair, M, Winckler, WK
openaire +3 more sources
Topological field theory and physics
, 1995 Topological Yang-Mills theory with the Belavin-Polyakov-Schwarz-Tyupkin $SU(2)$ instanton is solved completely, revealing an underlying multi-link intersection theory.
+12 more
core +2 more sources
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Building castles in Spain: Peirce’s idea of scientific inquiry and its applications to the Social Sciences and to Ethics [PDF]
, 2016 Several recent publications attest to a renewed interest, at the dawn of the 21st century, in the philosophy of Charles S. Peirce. While agreeing with the relevance of Peirce philosophy for the 21st century, we disagree with some interpretations of ...
Galanes Valldejuli, Luis, Nubiola, Jaime
core