Results 81 to 90 of about 6,696,068 (275)
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Relevance theory, humour, and the narrative structure of humorous novels
, 2000 Recent work on the application of relevance theory to humorous speech-acts (jokes) defines these as being characterised by an increased demand in processing effort for the attainment of maximum contextual effects.
Larkin Galiñanes, Cristina
core +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Relevance of Agency Theory in Software Development [PDF]
, 2013 In the Information technology field there has been lots of development. The development of software is increasing every day. IT professional are developing software for different business needs.
Dipendra Ghimire
core
Completeness of relevant quantification theories.
Notre Dame Journal of Formal Logic, 1974 In [20], Meyer and Dunn answered affirmatively for the relevant sentential logics E and R the question, "Is the rule y, 'From v-A and f-Av5, to infer B,' admissible?" This result, which confirmed an old conjecture of Anderson and Belnap, establishes the weak completeness of these and a number of related logics.
Meyer, Robert K. +2 more
openaire +5 more sources
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
"Honourable Bigotry"? Relevance theory, conversation analysis and radio talk-backs
, 2006 Relevance Theory (RT) and Conversation Analysis (CA), two disciplines with a shared interest in the pragmatics of conversation, have interacted very little.
Pattemore, Stephen
core +1 more source
Argumentation and Cognition: Can Pragma-Dialectics Interplay with Pragma-Semantics?
Critical Approaches to Discourse Analysis across Disciplines, 2007 This paper addresses the possibility of a cognitive account of argumentation, by focusing on a tentative interplay between one of today’s most influential theories of argumentation – van Eemeren and Grootendorst’s Pragma-Dialectics – and Relevance Theory.
Steve Oswald
doaj