Results 111 to 120 of about 6,696,068 (275)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Communication, information, and relevance
, 1998 Relevance theory has been developed as a general model for explaining the cognitive mechanisms underlying human verbal communication. As all theories, Relevance has been built up on several initial hypotheses.
García Murga, Fernando
core +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Studies in Logic, Grammar and RhetoricThe paper proposes a novel longitudinal approach to the study of the rhetorical effects of media by combining Audience Research (e.g. Schrøder et al., 2003), Social Semiotics (e.g.
Castaldi Jacopo
doaj +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
This chapter is a follow-up paper to Albl-Mikasa (2023), which for the first time applied Relevance Theory to English as a lingua franca, or ELF, and ELF interpreting.
Albl-Mikasa, Michaela
core
The Theory of Optimal Taxation: New Developments and Policy Relevance [PDF]
The theory of optimal taxation has often been criticized for being of little practical policy relevance, due to a lack of robust theoretical results. This paper argues that recent advances in optimal tax theory has made that theory easier to apply and ...
Peter Birch Sørensen
core
Vision-Based Attentiveness Determination Using Scalable HMM Based on Relevance Theory. [PDF]
Sensors (Basel), 2019 Tiawongsombat P +4 more
europepmc +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Scripted Misunderstandings and Humour: A Case Study of Monty Python’s Dialogues
Psychology of Language and CommunicationThe major goal of this paper is to explore the pragmatic mechanisms underlying the interpretation of fabricated misunderstandings designed to generate humour.
Kavetska Alisa Anastasiia
doaj +1 more source