Results 41 to 50 of about 147,987 (297)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Logic and Logical Philosophy, 2019 In this paper, a connexive extension of the Relevance logic R→ was presented. It is defined by means of a natural deduction system, and a deductively equivalent axiomatic system is presented too. The goal of such an extension is to produce a logic with stronger connection between the antecedent and the consequent of an implication.
openaire +3 more sources
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
Environment InternationalAccording to the World Health Organisation and European Commission definitions, substances shall be considered as having endocrine disrupting properties if they show adverse effects, have endocrine activity and the adverse effects are a consequence of ...
Laurent Lagadic +9 more
doaj +1 more source
Notre Dame Journal of Formal Logic, 1986 This is a continuation of the author's investigations [J. Symb. Logic 49, 334-342 (1984; Zbl 0586.03017)] of logics designed to overcome a perceived tension between extensional and intensional features of relevant logics. (This issue has been discussed frequently by relevant logicians. \textit{R. K. Meyer} and \textit{M. A.
openaire +2 more sources
Intelligent Tutoring Systems for Adult Learning in STEM Disciplines
New Directions for Adult and Continuing Education, EarlyView.ABSTRACT Intelligent tutoring systems (ITS) are reshaping adult learning in STEM by providing adaptive, data‐driven instruction across classrooms, workplaces, and informal environments. In the context of ITS, this article compares generative AI, which creates personalized explanations and practice materials, with explainable AI, which focuses on ...
Jill Zarestky, Amanda R. Lager Gleason
wiley +1 more source
Metaphysics, 2011 According to Ibn Sina's logic, Lozomieh is the only conditional that is suitable to be named real conditional. Also Lozomieh is among the foundations of Ibn Sina’s logic that the rules Modus Ponens and Modus Tollens would be applied only to it ...
M Hajihosseini
doaj
ASEAS - Austrian Journal of South-East Asian Studies, 2020 Drawing on neo-institutionalism in policy studies, this paper aims to demonstrate that transdisciplinarity is a new logic that could challenge the existing institutional logic of the knowledge production system in Vietnam. This institutional interplay is
Nguyen Minh Doi
doaj +1 more source
On the history of teaching logic at the St. Volodymyr University
Філософія освіти, 2023 The history of logic in Ukraine is still not sufficiently studied. Researchers, as a rule, analyze the legacy of outstanding scholars from a historical-philosophical point of view, paying attention to philosophical problems considered in their works ...
Ірина Хоменко
doaj +1 more source