Results 81 to 90 of about 29,958,447 (288)

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

open access: yesFEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas   +6 more
wiley   +1 more source

ON RELIABILITY-BASED OPTIMIZATION IN RIGID-PLASTIC FRAME DESIGN [PDF]

open access: yesStatyba, 1997
Santrauka Straipsnyje nagrinėjamas duoto patikimumo diskretinės rėminės konstrukcijos projektavimo uždavinys. Konstrukcijos geometriniai parametrai, apkrovų pridėjimo, pavojingų pjūvių vietos yra apibrėžiamos fiksuotai (determinuotai). Isorinės apkrovos ir konstrukcijos medžiaga—stochastinės. Nagrinėjamas vienintelis galimas konstrukcijos suirimo tipas—
openaire   +1 more source

Exploring the influence of lactoferrin on wound healing and related signaling pathways: a systematic review

open access: yesFEBS Open Bio, EarlyView.
Lactoferrin promotes wound healing by activating MAPK, PI3K/Akt, and extracellular matrix pathways, enhancing fibroblast remodeling, proliferation, and re‐epithelialization. These mechanisms highlight its therapeutic potential in inflammation control, tissue repair, and remodeling.
Morgana Lüdtke Azevedo   +4 more
wiley   +1 more source

Reliability-based multidisciplinary design and optimization for twin-web disk using adaptive Kriging surrogate model

open access: yesAdvances in Mechanical Engineering, 2016
Compared with the conventional single web disk, the twin-web disk has been designed as the future trend of the high-pressure turbine disk by the US Integrated High Performance Turbine Engine Technology program due to its breakthrough in weight loss ...
Mengchuang Zhang, Wenxuan Gou, Qin Yao
doaj   +1 more source

A Concurrent Approach for a Reliability-Based Optimization Design Problem

open access: yesJournal of Advanced Mechanical Design, Systems, and Manufacturing, 2012
A concurrent approach, which considers variability in design parameters, is proposed for a reliability-based design optimization (RBDO) problem. The RBDO is reformulated as a system with a bi-level structure, consisting of upper and lower levels.
Kuo-Wei LIAO, Buo-Chang LU, Si-Ping YU
doaj   +1 more source

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

open access: yesFEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda   +4 more
wiley   +1 more source

Reliability-Based Optimization of Robust Feasibility in Mechanical Design Using PVP Technique and Fuzzy Formulation

open access: yes, 2013
This paper presents a three‐stage integrated optimum design procedure for obtaining the highest design level of robust feasibility and optimum design performance with random variables.
Shih, Chien-jong; Tseng, Ting-chang
core   +1 more source

Genetic dissection of human ABCE1 in yeast reveals separable requirements for ribosome recycling and suppression of aberrant reinitiation

open access: yesFEBS Open Bio, EarlyView.
Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata   +3 more
wiley   +1 more source

System Reliability-Based Design and Multiresolution Topology Optimization [PDF]

open access: yes, 2010
Structural optimization methods have been developed and applied to a variety of engineering practices. This study aims to overcome technical challenges in applying design and topology optimization techniques to large-scale structural systems with ...
Nguyen, Tam H.
core  

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