Results 61 to 70 of about 29,958,447 (288)

Reliability-based design using variable-fidelity optimization [PDF]

Structure and Infrastructure Engineering, 2005
Competitive marketplaces have driven the need for simulation-based design optimization to produce efficient and cost-effective designs. However, such design practices typically do not take into account model uncertainties or manufacturing tolerances.
Shawn Gano, Harish Agarwal, John Renaud, Andres Tovar   +3 more
openaire   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Reliability-based design optimization of ship structure using SMOTE algorithm and dynamic surrogate model

Zhongguo Jianchuan Yanjiu, 2020
Objectives Aiming at the problem that it is difficult to ensure global approximation accuracy and computational efficiency in the traditional reliability-based design optimization of ship structures, a reliability optimization strategy based on a dynamic
LIU Jing, WANG Deyu
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Computational engineering design under uncertainty: an aircraft conceptual design perspective [PDF]

, 2009
Presented in this thesis is a novel methodology for aircraft design optimization in the presence of uncertainty, with emphasis on the conceptual design stage.
Padulo, Mattia
core   +5 more sources

A Modified Conjugate Gradient Approach for Reliability-Based Design Optimization

IEEE Access, 2020
To improve the efficiency of structural reliability-based design optimization (RBDO) based on the performance measure approach (PMA), a modified conjugate gradient approach (MCGA) is proposed for RBDO with nonlinear performance function.
Zhiming Wang, Yafei Zhang, Yalong Song
doaj   +1 more source

Reliability based geometrically nonlinear bi-directional evolutionary structural optimization of elasto-plastic material

Scientific Reports, 2022
The aim of this paper is to integrate the reliability-based analysis into topology optimization problems. Consequently, reliability-based topology optimization (RBTO) of geometrically nonlinear elasto-plastic models is presented.
Muayad Habashneh, Majid Movahedi Rad
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source