Results 51 to 60 of about 128,348 (264)
A Modified Conjugate Gradient Approach for Reliability-Based Design Optimization
IEEE Access, 2020 To improve the efficiency of structural reliability-based design optimization (RBDO) based on the performance measure approach (PMA), a modified conjugate gradient approach (MCGA) is proposed for RBDO with nonlinear performance function.
Zhiming Wang, Yafei Zhang, Yalong Song
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Scientific Reports, 2022 The aim of this paper is to integrate the reliability-based analysis into topology optimization problems. Consequently, reliability-based topology optimization (RBTO) of geometrically nonlinear elasto-plastic models is presented.
Muayad Habashneh, Majid Movahedi Rad
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Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
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Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
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Fuzzy Design Optimization-Based Fatigue Reliability Analysis of Welding Robots
IEEE Access, 2020 In this work, a fuzzy design optimization-based fatigue reliability analysis technique is addressed to obtain the optimal fatigue reliability of the structures with random parameters under the minimum fluctuation of fatigue life.
Pengpeng Zhi +4 more
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Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
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Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
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Jixie qiangdu, 2022 In order to improve the working reliability of the biomimetic robotic fish, put forward a gradient reliability robust optimization design method method which is applied to the biomimetic robotic fish.Taken the bionic killer whale as the research object ...
LI MingHao +3 more
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Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
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Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
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