Results 41 to 50 of about 128,348 (264)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

open access: yesFEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho   +3 more
wiley   +1 more source

High reliability transmission optimization design of LVDS based on FPGA

open access: yesDianzi Jishu Yingyong, 2018
In order to solve the problem of bit error and short transmission distance in the process of LVDS high-speed link transmission, the optimization scheme is proposed from hardware and logic coding respectively.
Li Beiguo, Yang Shenglong, Li Huijing
doaj   +1 more source

Reliability-based optimization of ship structure based on interest subdomain dynamic surrogate model

open access: yesZhongguo Jianchuan Yanjiu, 2021
ObjectivesAiming at the difficulty of ensuring the fitting accuracy and optimization efficiency of surrogate models due to the high nonlinearity in ship structure reliability-based optimization design, a reliability-based ship structure optimization ...
Wenjun LUO, Deyu WANG
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

Optimization Design of Computer Network Reliability Based on Genetic Algorithms

open access: yesChemical Engineering Transactions, 2016
With the acceleration of the process of information society, not only the user's computer communication networks is increasing, but also the rapid expansion of computer communication network connecting regional scale and network connections.
L.J. Liu
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Reliability-based design using variable-fidelity optimization [PDF]

open access: yesStructure and Infrastructure Engineering, 2005
Competitive marketplaces have driven the need for simulation-based design optimization to produce efficient and cost-effective designs. However, such design practices typically do not take into account model uncertainties or manufacturing tolerances.
Shawn Gano   +3 more
openaire   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

Reliability-based design optimization of ship structure using SMOTE algorithm and dynamic surrogate model

open access: yesZhongguo Jianchuan Yanjiu, 2020
Objectives Aiming at the problem that it is difficult to ensure global approximation accuracy and computational efficiency in the traditional reliability-based design optimization of ship structures, a reliability optimization strategy based on a dynamic
LIU Jing, WANG Deyu
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

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