Results 41 to 50 of about 29,958,447 (288)
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Comparative study of methods for optimization of electromagnetic devices with uncertainty [PDF]
, 2018 This paper compares different probabilistic optimization methods dealing with uncertainties. Reliability-Based Design Optimization is presented as well as various approaches to calculate the probability of failure. They are compared in terms of precision
Siyang Deng +5 more
core +1 more source
Reliability-Based Optimization of Impeller Structure Using Exponential Function Approximation
Applied SciencesThis study proposes a decoupling approach based on first-order exponential function approximation for reliability-based optimization. It establishes an explicit relationship between the failure probability and design parameters within only one ...
Haiwei Lin +5 more
doaj +1 more source
Advances in Mechanical Engineering, 2018 Conventional decoupling approaches usually employ first-order reliability method to deal with probabilistic constraints in a reliability-based design optimization problem.
Zhiliang Huang +2 more
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Interactive methodology for reliability-based structural design and optimization
Computer Assisted Methods in Engineering and Science, 2023 Recent advances in reliability methods, optimization as well as design sensitivity analysis have resulted in development of computational systems supporting RBDO processes for medium/large structures. For RBDO the efficiency problems are critical and in
Rafał Stocki +2 more
doaj
Applied Sciences, 2017 In reliability-based and cost-oriented product optimization, the target product reliability is apportioned to subsystems or components to achieve the maximum reliability and minimum cost.
Zhaoxi Hong +4 more
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
International Journal of Science and Engineering, 2015 This paper presents Reliability Based Design Optimization (RBDO) model to deal with uncertainties involved in concrete mix design process. The optimization problem is formulated in such a way that probabilistic concrete mix input parameters showing ...
Rachna Aggarwal +3 more
doaj +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source