Results 51 to 60 of about 374,715 (265)

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

open access: yesMolecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Satellite system performance assessment for in-flight entertainment and air traffic control [PDF]

open access: yes, 2007
Concurrent satellite systems have been proposed for IFE (In-Flight Entertainment) communications, thus demonstrating the capability of satellites to provide multimedia access to users in aircraft cabin. At the same time, an increasing interest in the use
Bousquet, Michel   +3 more
core   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

Technical Solution and Economic Analysis for Natural Gas Distributed Energy Unit Combined Cooling and Power Supply of Data Center

open access: yes南方能源建设, 2019
[Introduction] Inorder to improve the reliability requirements and effectively reduce energy consumption, the paper proposes a comprehensive solution for a mains + natural gas distributed energy system and analyze the technical feasibility and economy of
LIU Wei, YUAN Hansheng
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

open access: yesMolecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic   +5 more
wiley   +1 more source

Psychometric properties of the English language version of the C-BiLLT evaluated in typically developing Canadian children

open access: yesJournal of Pediatric Rehabilitation Medicine, 2023
PURPOSE: This study aimed to 1) investigate the convergent and discriminant validity, internal consistency, and test-retest reliability of the Canadian English version of the Computer-Based instrument for Low motor Language Testing (C-BiLLT-CAN), and 2 ...
Jael N. Bootsma   +9 more
doaj   +1 more source

Expander selection for an on board ORC energy recovery system [PDF]

open access: yes, 2017
This paper deals with the comparison between volumetric expanders (screw, scroll and rotary vane) and an Inlet Forward Radial (IFR) micro turbine for the exploitation of an on board Organic Rankine Cycle (ORC) energy recovery system.
Capata, Roberto, Fabio, Pantano
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Maximising the potential of ICT to provide authentic summative assessment opportunities [PDF]

open access: yes, 2012
This paper reports on elements of a study that was conducted in Western Australia to explore the potential of various forms of digitally based external assessments for senior secondary school courses. One problem that needed addressing was how to provide
Williams, P. John
core  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

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