Results 61 to 70 of about 24,260,019 (288)

Reliability and fault tolerance modelling of multiprocessor systems [PDF]

, 1989
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.Reliability evaluation by analytic modelling constitute an important issue of designing a reliable multiprocessor system.
Valdivia, Roberto Abraham
core   +5 more sources

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Vision-Based Situational Graphs Exploiting Fiducial Markers for the Integration of Semantic Entities

Robotics
Situational Graphs (S-Graphs) merge geometric models of the environment generated by Simultaneous Localization and Mapping (SLAM) approaches with 3D scene graphs into a multi-layered jointly optimizable factor graph.
Ali Tourani, Hriday Bavle, Deniz Işınsu Avşar, Jose Luis Sanchez-Lopez, Rafael Munoz-Salinas, Holger Voos   +5 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Reliability analysis and micromechanics: A coupled approach for composite failure prediction [PDF]

, 2011
This work aims at associating two classical approaches for the design of composite materials: first, reliability methods that allow to account for the various uncertainties involved in the composite materials behaviour and lead to a rational estimation ...
Welemane, Hélène, H. Welemane, H. Dehmous, Dehmous, Hocine   +3 more
core   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Temporal Network Reliability in Perturbed Scenarios: Application to a SCADA System

, 2012
The role of network reliability in the analysis of Critical Infrastructures (CI) is investigated showing that the traditional approach must be extended in two directions: to include the packet propagation time along the links for real time analysis, and ...
Bonaventura, Alessandro, Ester Ciancamerla, TERRUGGIA, Roberta, Ciancamerla, Ester, E. Ciancamerla, D. Lefevre, A. Bonaventura, M. Minichino, Roberta Terruggia, BOBBIO, Andrea, Minichino, Michele, Michele Minichino, Lefevre, Davide, Davide Lefevre, Andrea Bobbio, Alessandro Bonaventura   +15 more
core   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Intelligent reliability analysis with incomplete covariates [PDF]

, 2012
The reliability analysis is crucial to reducing unexpected down time, severe failures and ever tightened maintenance budget of engineering assets. Hazard based reliability methods are of particular interest as hazard reflects the current health status of
Yu, Yi
core