Results 81 to 90 of about 1,247,116 (346)

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

A Bayesian Approach to Step-Stress Partially Accelerated Life Testing for a Novel Lifetime Distribution

Axioms
In lifetime testing, the failure times of highly reliable products under normal usage conditions are often impractically long, making direct reliability assessment impractical.
Mervat K. Abd Elaal, Hebatalla H. Mohammad, Zakiah I. Kalantan, Abeer A. EL-Helbawy, Gannat R. AL-Dayian, Sara M. Behairy, Reda M. Refaey   +6 more
doaj   +1 more source

Assessing the validity and reliability of the Arabic versions of Mini Asthma Quality of life questionnaire and Asthma Control Test in adult patients with asthma: A factor analysis study

, 2023
Walid Al‐Qerem, Anan S. Jarab, Abdel Qader Al Bawab, Alaa M. Hammad, Jonathan Ling, Fawaz Alasmari, Khaled Al Oweidat, Sarah Ibrahim   +7 more
openalex   +1 more source

Reliability Issues with PME and BME Ceramic Capacitors [PDF]

This work is a review of reliability issues specific for low-voltage precious metal electrode (PME) and base metal electrode (BME) multilayer ceramic capacitors (MLCC).
Teverovsky, Alexander
core   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Parameter Estimates of General Failure Rate Model: A Bayesian Approach [PDF]

, 2014
The failure rate function plays an important role in studying the lifetime distributions in reliability theory and life testing models. A study of the general failure rate model $r(t)=a+bt^{\theta-1}$, under squared error loss function taking $a$ and $b$
Kundu, Amarjit, Kundu, Chanchal, Maiti, Sudhansu S., Nanda, Asok K.   +3 more
core  

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Fatigue Reliability Analysis of Wind Turbine Cast Components

Energies, 2017
The fatigue life of wind turbine cast components, such as the main shaft in a drivetrain, is generally determined by defects from the casting process.
Hesam Mirzaei Rafsanjani, John Dalsgaard Sørensen, Søren Fæster, Asger Sturlason   +3 more
doaj   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Preliminary design of the redundant software experiment [PDF]

The goal of the present experiment is to characterize the fault distributions of highly reliable software replicates, constructed using techniques and environments which are similar to those used in comtemporary industrial software facilities.
Campbell, Roy, Deimel, Lionel, Eckhardt, Dave, Jr., Kelly, John, Knight, John, Lauterbach, Linda, Lee, Larry, Mcallister, Dave, Mchugh, John   +8 more
core   +1 more source