Results 61 to 70 of about 331,385 (252)
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
Optimization of Exponential Distribution Testing Period Based on Reliability Degradation
, 2010 For high reliability and long-life equipments, regular test on their performance is an effective approach to keep a fine status during the whole life. Because the number of failures increases with the duration of service, it is very important to use a ...
Zheng Li +3 more
core +1 more source
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
, 2009 The ALT'2006 meeting "Degradation, Damage Fatigue and Accelerated Life Models in Reliability Testing" was the first international conference in Europe devoted to accelerated life testing and closely related topics in reliability.
Guerin, Fabrice +3 more
core +1 more source
Applied SciencesThis study focuses on the reliability assessment of a series system composed of Weibull-distributed components. Because high-reliability components rarely fail during life testing or actual operation, conventional system reliability analysis methods ...
Ziang Li, Huimin Fu, Jianchao Guo
doaj +1 more source
Design of Control Chart in Presence of Hybrid Censoring Scheme
IEEE Access, 2018 In this paper, a new reliability testing control chart has been developed using the hybrid censoring scheme for the Weibull distribution. The in-control and out-of-control probabilities are estimated for the desired quality characteristic using the ...
Muhammad Aslam +2 more
doaj +1 more source
Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis
FEBS Letters, EarlyView.This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng +8 more
wiley +1 more source
Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy
FEBS Letters, EarlyView.The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley +1 more source
Fitting and Optimal Grouping on Gamma Reliability Data
, 1987 The paper presents two statistics for testing gammality based on complete and incomplete random samples with unknown scale parameter. The distributions of the test statistics were approximated by using Monte Carlo simulation.
Wei, Duan; Bau, Jimm-jomp +2 more
core +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source