Results 61 to 70 of about 290,108 (258)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

A Critical Analysis of Deepfake Detection Software: Emerging Challenges and Quality Assurance

International Journal of Emerging Engineering and Technology
Deepfakes have proven their identity in the field of digital forensics. The article explains how Deepfakes create highly realistic but synthetic videos, images, and audio clips, which create doubt about whether they are real or fake.
Imran Nawaz Rana, Irshad Ahmed Sumra, Syeda Shan-e-Zahra   +2 more
doaj   +1 more source

Quantitative Accelerated Life Testing of MEMS Accelerometers

Sensors, 2007
Quantitative Accelerated Life Testing (QALT) is a solution for assessing thereliability of Micro Electro Mechanical Systems (MEMS). A procedure for QALT is shownin this paper and an attempt to assess the reliability level for a batch of ...
Jean-Paul Collette, Serge Habraken, Jerome Loicq, Virgil Emil Ilian, Lucian Gălăţeanu, Marius Bâzu   +5 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Fatigue Reliability Analysis of Wind Turbine Cast Components

Energies, 2017
The fatigue life of wind turbine cast components, such as the main shaft in a drivetrain, is generally determined by defects from the casting process.
Hesam Mirzaei Rafsanjani, John Dalsgaard Sørensen, Søren Fæster, Asger Sturlason   +3 more
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Amputated life-testing based on extended Dagum percentiles for type of group inspection plans: optimal sample sizes, termination time ratios analysis

Scientific Reports
This paper introduces a novel approach to life-testing using Extended Dagum (EXD) percentiles within the framework of group inspection plans. The methodology focuses on optimizing sample sizes and analyzing termination time ratios to enhance the ...
Basma Ahmed, G. G. Hamedani, Getachew Tekle Mekiso, Yusra A. Tashkandy, M. E. Bakr, Eslam Hussam, Haitham M. Yousof   +6 more
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Estimation and prediction constant stress accelerated life testing for gull alpha power Fréchet distribution [PDF]

مجلة العلوم التجارية والبيئية
Traditional life Analysis of data involves examining time-to-failure outcomes (for a system, component, or product) collected according to usual conditions to evaluate life specifications and provide predictions regarding product performance.
Sahar H. A. Osman, Reda M. H. Refaey, Sara M. A. Behairy, Gannat R. Aldayian   +3 more
doaj   +1 more source