Results 51 to 60 of about 2,447,567 (258)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Assessing the reliability of adaptive power system protection schemes [PDF]

open access: yes, 2012
Adaptive power system protection can be used to improve the performance of existing protection schemes under certain network conditions. However, their deployment in the field is impeded by their perceived inferior reliability compared to existing ...
Abdulhadi, Ibrahim Faiek   +3 more
core   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

Reliability and maintainability assessment factors for reliable fault-tolerant systems [PDF]

open access: yes, 1984
A long term goal of the NASA Langley Research Center is the development of a reliability assessment methodology of sufficient power to enable the credible comparison of the stochastic attributes of one ultrareliable system design against others.
Bavuso, S. J.
core   +1 more source

Reliability assessment of microgrid with renewable generation and prioritized loads

open access: yes, 2017
With the increase in awareness about the climate change, there has been a tremendous shift towards utilizing renewable energy sources (RES). In this regard, smart grid technologies have been presented to facilitate higher penetration of RES.
Ansari, O. A., Chung, C. Y., Safar, N.
core   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra   +6 more
wiley   +1 more source

Reliability assessment of wind turbines

open access: yes, 2013
Wind turbines can be considered as structures that are in between civil engineering structures and machines since they consist of structural components and many electrical and machine components together with a control system. Further, a wind turbine is not a one-of-a-kind structure but manufactured in series production based on many component tests ...
openaire   +4 more sources

Human assessments of document similarity [PDF]

open access: yes, 2010
Two studies are reported that examined the reliability of human assessments of document similarity and the association between human ratings and the results of n-gram automatic text analysis (ATA).
Belkin   +28 more
core   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

Patient Perceptions of Clinician\u27s Empathy: Measurement and Psychometrics. [PDF]

open access: yes, 2017
The prominence of reciprocal understanding in patient–doctor empathic engagement implies that patient perception of clinician’s empathy has an important role in the assessment of the patient–clinician relationship. In response to a need for an assessment
DeSantis, Jennifer   +2 more
core   +1 more source

Home - About - Disclaimer - Privacy