Results 131 to 140 of about 2,407,909 (292)

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

RELIABILITY ENHANCEMENT METHOD FOR «ARBITER» PHYSICALLY UNCLONABLE FUNCTION

Informatika, 2017
The paper presents a reliability enhancement method for an arbiter physically unclonable function (A-PUF). The proposed technique has reasonable challenge-response generation time and does not cause additional hardware overheads.
V. P. Klybik, S. S. Zalivaka, A. A. Ivaniuk   +2 more
doaj  

The validity and reliability test of the mini-mental state pediatric examination (MMSPE) as a screening instrument for cognitive function in Indonesian-speaking children

BMC Pediatrics
Background Cognitive function is one of the important aspects in the period of a child’s development. Cognitive dysfunction can be a risk factor of neuropsychological development disorders.
R. A. Setyo Handryastuti, Nenden Nursyamsi Agustina, Rini Sekartini, Teny Tjitra Sari, Irawan Mangunatmadja, Bambang Tridjaja, Ali Nina Liche Seniati, Bernadette Kushartanti   +7 more
doaj   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Translation, cross-cultural adaptation and validation of psychometric properties of foot function index in Urdu-speaking population with ankle and foot disorders

BMC Musculoskeletal Disorders
Background Foot and ankle problems are frequently prevalent, especially among the elderly, ranging from 70 to 80%. In primary care, foot, and ankle complaints stand out as one of the most frequent reasons for orthopedic consultations.
Aqsa Anjum, Sana Tauqeer, Ayesha Arooj, Hassan Javed, Hammad Shakeel, Ammarah Ikram   +5 more
doaj   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

CASE STUDY ON RELIABILITY AND MAINTENANCE ANALYSIS OF MACHINERY IN AN INDUSTRIAL CONTEXT [PDF]

Fiabilitate şi Durabilitate
The reliability and maintenance of machinery are essential aspects in modern industry, significantly impacting operational efficiency and production costs.
Grațian-Daniel GOLOȘIE, Andrada-Denisa BECA, Claudia-Irina CAZACU   +2 more
doaj  

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source