Results 51 to 60 of about 3,175,550 (304)
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
ENSURING OF PARAMETRIC RELIABILITY OF HEAT SUPPLY SYSTEMS
Известия высших учебных заведений: Проблемы энергетики, 2017 The paper suggests a methodology to determine optimal reliability parameters (failure and restoration rates) of heat supply system components, which provide the required level of heat supply reliability.
I. V. Postnikov, V. A. Stennikov
doaj +1 more source
Machines, 2023 As increasingly extensive applications of flexible manufacturing systems (FMSs) arise, their reliability allocation has been a research hot spot. But, since FMSs are always composed of transfer and buffer devices, production machines, and complex control
Jingjing Xu +5 more
doaj +1 more source
Reliability approach for fibre-reinforced composites design [PDF]
, 2007 This study aims at investigating the mechanical reliability of unidirectional fibre-reinforced composites in view of their design optimization. Owing to the manufacturing process, many uncertainties affect inherently the properties of these materials ...
Karama, Moussa +11 more
core +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Empirical bayes estimates of development reliability for one shot devices [PDF]
, 2009 This article describes a method for estimating the reliability of a system under development that is an evolution of previous designs. We present an approach to making effective use of heritage data from similar operational systems to estimate ...
Quigley, J.L. +2 more
core +3 more sources
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Fractal and FractionalResearch on reliability control for enhancing power systems under random loads holds significant and undeniable importance in maintaining system stability, performance, and safety.
Mingzhi Lin +3 more
doaj +1 more source
A Review of Optimization for System Reliability of Microgrid
Mathematics, 2023 Clean and renewable energy is the only way to achieve sustainable energy development, with considerable social and economic benefits. As a key technology for clean and renewable energy, it is very important to research the reliability optimization of ...
Bingyin Lei +7 more
doaj +1 more source