Results 71 to 80 of about 3,175,550 (304)

Structural Reliability and Optimization Using Differential Geometric Approaches

Iraqi Journal for Computer Science and Mathematics
This study investigates how differential geometry ideas can be used to effectively carry out structural optimization and reliability analysis. Strong mathematical representations and methods for examining intricate surfaces and forms are provided by ...
Saad Abbas Abed, Mona Ghassan, Shaemaa Qaes, Mahmood S. Fiadh , Zaid Amer Mohammed   +4 more
doaj   +1 more source

Distribution Reliability Optimization Using Synthetic Feeders

Energies, 2019
Historical distribution system reliability optimization approaches have relied on the creation of detailed feeder reliability models, which is extremely labor-intensive. This paper presents a reliability optimization approach using synthetic feeders that
Richard E. Brown, Rick Pinkerton
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Reliability Optimization of Structural Deformation with Improved Support Vector Regression Model

Advances in Materials Science and Engineering, 2020
Deformation is one important failure mode of turbine blades. The quality of a model seriously influences the reliability optimization of turbine blades in turbo machines.
Zheng-Zheng Zhu, Yun-Wen Feng, Cheng Lu, Cheng-Wei Fei   +3 more
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

A Novel Multi-Objective Dynamic Reliability Optimization Approach for a Planetary Gear Transmission Mechanism

Axioms
Planetary gear transmission mechanisms (PGTMs) are widely used in mechanical transmission systems due to their compact structure and high transmission efficiency.
Shuiguang Tong, Xiaoyan Yan, Lechang Yang, Xianmiao Yang   +3 more
doaj   +1 more source

Reliability in the whole life cycle of building systems [PDF]

, 2006
Purpose – The purpose of this research is to show that reliability analysis and its implementation will lead to an improved whole life performance of the building systems, and hence their life cycle costs (LCC). Design/methodology/approach – This paper
Sidhu, J., Neale, K., Wu, Shaomin, Neale, Keith, Clements-Croome, Derek, Albany, B., Desmond, Duncan, Wu, S., Albany, Bob, Sidhu, Jogi, Fairey, Vic, Clements-Croome, Derek J., Desmond, D., Fairey, V.   +13 more
core   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source