Results 41 to 50 of about 1,358,459 (299)

Global sensitivity analysis in stability problems of steel frame structures

Journal of Civil Engineering and Management, 2016
Slender steel frame structures are characterised by a number of imperfections which may reduce their load carrying capacity drastically. This article studies the effects of these imperfections on the load carrying capacity of a single storey steel plane ...
Zdeněk Kala
doaj   +1 more source

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács, Zoltán Köllő, Balázs Gellért Karvaly, Mahmoud Obeidat, Rita Nagy, Péter Hegyi, Brigitta Teutsch, Eszter Tuboly, Miklós Garami   +8 more
wiley   +1 more source

Reliability and sensitivity assessment of laminated composite plates with high-dimensional uncertainty variables using active learning-based ensemble metamodels

Curved and Layered Structures
Laminated composite materials play a crucial role in various engineering applications due to their exceptional mechanical properties. This article explores the analysis of reliability and the local sensitivity of failure probability associated with ...
Zemed Najib, Mouzoun Kaoutar, Moulay Abdelali Hanane, Cherradi Toufik, Bouyahyaoui Azzeddine   +4 more
doaj   +1 more source

Reliability-Based Robust Design Optimization with Fourth-Moment Method for Ball Bearing Wear

Lubricants
Ball bearings operating at low speeds and under heavy loads are susceptible to wear failure, leading to significant economic losses. The existing reliability-based robust design optimization method of the fourth-moment method has high accuracy and does ...
Yanzhong Wang, Shiyuan E, Kai Yang, Bin Xie, Fengxia Lu   +4 more
doaj   +1 more source

Reliability & Sensitivity Analysis of IKR Regional power Network [PDF]

Iraqi Journal for Electrical and Electronic Engineering, 2011
This paper presents a developed algorithm for reliability sensitivity analysis of engineering networks. . Reliability Modeling is proposed for the Iraqi Kurdistan Regional Power Network (IKRPN) using Symbolic Reliability function of the model.
Asso Raouf Majeed
doaj  

Sensitivity analysis of the CREAM method for Human Reliability [PDF]

, 2008
This paper reports a sensitivity analysis of the CREAM HRA method. We consider three different aspects: the difference between the outputs of the Basic and Extended methods, on the same HRA scenario; the variability in outputs through the choices made ...
Bayley, Clare, Bedford, T.J.
core  

Reliability models of belt drive systems under slipping failure mode

Advances in Mechanical Engineering, 2017
Conventional reliability assessment and reliability-based optimal design of belt drive are based on the stress–strength interference model. However, the stress–strength interference model is essentially a static model, and the sensitivity analysis of ...
Peng Gao, Liyang Xie
doaj   +1 more source

Evaluating the Utility of Paired Tumor and Germline Targeted DNA Sequencing for Pediatric Oncology Patients: A Single Institution Report

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate the diagnostic yield and utility of universal paired tumor–normal multigene panel sequencing in newly diagnosed pediatric solid and central nervous system (CNS) tumor patients and to compare the detection of germline pathogenic/likely pathogenic variants (PV/LPVs) against established clinical referral criteria for cancer ...
Natalie Waligorski, Rebecca Ronsley, Shannon M. Stasi, Jeffrey Stevens, Erin R. Rudzinski, Christina M. Lockwood, Sarah E. S. Leary, Bonnie L. Cole, Michelle A. Ting, Vera Paulson   +9 more
wiley   +1 more source

Validity, practical utility, and reliability of the activPAL in preschool children [PDF]

, 2012
<p>Purpose: With the increasing global prevalence of childhood obesity, it is important to have appropriate measurement tools for investigating factors (e.g. sedentary time) contributing to positive energy balance in early childhood. For pre-school
Aminian, AMY J. MCGOWAN, Arvidsson, Bailey, Bland, Busser, Bussmann, Cole, de Onis, Foerster, Ford, Franks, Freeman, Godfrey, Grant, Guo, GWYNETH DAVIES, Healy, Hu, Jackson, JAMES Y. PATON, JOHN J. REILLY, Langer, Lanningham-Foster, Lyons, Mackey, MALCOLM H. GRANAT, Mathie, Najafi, Paraschiv-Ionescu, Penpraze, PHILIPPA M. DALL, Reilly, Ryan, Steinberger, Trost, Uiterwaal, White, Zhang   +38 more
core   +1 more source

The Fate (Outcome) of Clinically Apparent Single Lesion and Oligofocal Nephroblastomatosis Treated According to SIOP/GPOH Protocols for Wilms Tumor

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background The management of clinically apparent single lesions or oligofocal nephroblastomatosis, a facultative precursor of nephroblastoma, remains debated. Methods We retrospectively analyzed 37 patients with clinically apparent single or oligofocal nephroblastomatosis (two to three lesions per kidney) among 2347 patients registered between
Nils Welter, Jens‐Peter Schenk, Jenny Wegert, Manfred Gessler, Leo Kager, Stefan Wagenpfeil, Marina Müller, Jean‐Michel Wolff, Joerg Fuchs, Steven W. Warmann, Clemens‐Magnus Meier, Jochen Hubertus, Christian Rübe, Christian Vokuhl, Patrick Melchior, Lena Tschirner, Norbert Graf, Rhoikos Furtwängler   +17 more
wiley   +1 more source