Results 81 to 90 of about 1,877,205 (300)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Boltzmann-like Entropy in Reliability Theory

Entropy, 2002
: We introduce the entropy function in order to study the reliability and repairability of systems. In detail we establish the explicit relationships between reliability and repairability; then we calculate the decay of a system due to its regular ...
Paolo Rocchi
doaj   +1 more source

Maximizing Service Reliability in Distributed Computing Systems with Random Node Failures: Theory and Implementation [PDF]

, 2010
In distributed computing systems (DCSs) where server nodes can fail permanently with nonzero probability, the system performance can be assessed by means of the service reliability, defined as the probability of serving all the tasks queued in the DCS ...
Dhakal, Sagar, Hayat, Majeed M., Pezoa, Jorge E.   +2 more
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Mathematical modeling of railway systems technical support readiness levels using an integral indicator based on the Harrington scale

Transportation and Information Technologies in Russia
Background. The relevance of the study is due to the increasing demands on the reliability and safety of railway transport. Modern railway automation and telemechanics systems are elaborate technical complexes, the failure of which can lead to ...
Aleksandr V. Gorelik, Elena V. Kuzmina
doaj   +1 more source

Percentile residual life orders [PDF]

, 2008
In this paper we study a family of stochastic orders of random variables defined via the comparison of their percentile residual life functions. Some interpretations of these stochastic orders are given, and various properties of them are derived. The
Franco Pereira, Alba María, Lillo Rodríguez, Rosa Elvira, Romo Urroz, Juan, Shaked, Moshe   +3 more
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Mathematical Optimization of Wind Turbine Maintenance Using Repair Rate Thresholds

Axioms
As reliance on wind energy intensifies globally, optimizing the efficiency and reliability of wind turbines is becoming vital. This paper explores sophisticated maintenance strategies, crucial for enhancing the operational sustainability of wind turbines.
Nataša Kontrec, Stefan Panić, Jelena Vujaković, Dejan Stošović, Sergei Khotnenok   +4 more
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Reinforcement learning layout‐based optimal energy management in smart home: AI‐based approach

IET Generation, Transmission & Distribution
This research addresses the pressing need for enhanced energy management in smart homes, motivated by the inefficiencies of current methods in balancing power usage optimization with user comfort. By integrating reinforcement learning and a unique column‐
Sajjad Afroosheh, Khodakhast Esapour, Reza Khorram‐Nia, Mazaher Karimi   +3 more
doaj   +1 more source